About this Research Topic
HBOC is typically suspected when ≥1 woman in the family is diagnosed before the age of 45; ≥1 woman in the family is diagnosed with breast cancer before the age of 50 with an additional family history of cancer (prostate or pancreatic cancer, melanoma); there is a history of breast and/or ovarian cancers in multiple generations on the same side of the family; there is a history of breast, ovarian and/or pancreatic cancer on the same side of the family; there is a history of breast and/or ovarian, pancreatic, or male breast cancer in a family of Ashkenazi Jewish ancestry; a woman is diagnosed with a second ipsilateral or contralateral breast cancer or with both breast and ovarian cancers; a male relative is diagnosed with breast cancer.
Following the discovery of the BRCA1 and BRCA2 genes and their link with HBOC, research has shown that screening programs, genetic testing and preventative measures can reduce mortality associated with HBOC by half, helping BRCA mutation carriers make informed decisions regarding the screening, prevention, and treatment of breast and ovarian cancer.
This Research Topic aims to present insights into HBOC including genetic testing, screening models, surgical and non-surgical prevention options as well as treatment modalities and their impact on patient outcomes. We welcome contributions focusing on but not limited to:
1) Hereditary breast and ovarian cancer: BRCA1/2 and beyond
2) Genetic testing for hereditary breast and ovarian cancer
3) Screening for hereditary breast and ovarian cancer
4) Surgical and non-surgical prevention of breast and ovarian cancer in BRCA mutation carriers
5) Surgical and systemic treatment of hereditary breast and ovarian cancer
Keywords: Breast, ovary, hereditary, prevention, treatment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.