About this Research Topic
This Research Topic welcomes original research and review articles on the subject of epigenetics and genetic regulation in heart failure developing. We also welcome methodological papers that analyse epigenetic biomarkers and papers that present new epigenetic biomarker-based models that could be effective in the prediction of heart failure.
Submissions are encouraged that discuss new epigenetic biomarkers such as single nucleotide polymorphisms, non-coding micro RNAs, DNA methylation, and histone modification as well as articles that clarify novel approaches in epigenetics and genetic regulation of both embryonic stem cells and induced pluripotent stem in heart failure. Articles that cover new technologies including advanced bioinformatics and computational predictions are also welcome. Finally, we also welcome papers that cover epigenetic mechanisms underlying diagnostic strategies and the use of therapeutic epigenetic molecules or epidrugs in patients at the risk of heart failure development.
Other potential themes include but are not limited to the following:
1) Conception and clinical implementation of epigenetic and genetic biomarker-based risk assessment in heart failure.
2) Cardiac transcriptional remodeling and hypertrophy.
3) DNA methylation and histone modification in heart failure and hypertrophy.
4) MicroRNAs signature in cardiac remodeling and heart failure.
5) Epigenetics and co-morbidities in different etiological subtypes of heart failure.
6) Endogenous cardiac regeneration via manipulating gene expressions.
7) Gene card in heart failure.
8) Pharmacological inhibition of transcriptional machinery.
9) Regenerative strategies in prevention of cardiac remodeling and heart failure.
Keywords: Heart Failure, Pathogenesis, Comorbidities, Epigenetics, Genetics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.