About this Research Topic
Heart disease remains a leading cause of death in both men and women in the United States and worldwide. For example, according to the Center for Disease Control (CDC), approximately 630,000 Americans die from heart disease each year—which is equivalent to 1 in every 4 deaths/year. Despite significant advancement in clinical and basic research approaches, the prevalence of heart disease continues to increase. Therefore, there is a critical need to identify novel and/or redefine existing molecular mechanisms that regulate cardiac function.
The problem is that these mechanisms are complicated involving multiple steps. For example, metabolic syndrome, which is often defined by individual and multiple combinations of several pathologies (obesity, diabetes, inflammation, insulin resistance, hyperinsulinemia, hypercholesterolemia, and hypertriglyceridemia), is a critical contributor to the increasing prevalence of heart disease. This notion suggests that if we have a holistic knowledge of the molecular mechanisms of metabolic cues, we may be able to better develop interventions that will help decrease mortality and improve the quality of life and cardiovascular health of patients worldwide.
The goal of this Research Topic is to initiate discussions in the form of review papers, perspectives, in-silico and original articles involving recent advances from clinical and animal studies for how normal /impaired metabolic cues contribute to adverse electrical, structural, and neural modulation of cardiac function. We encourage investigations of mechanism-based signaling pathways involving: central and peripheral circadian clock signaling, stress-activated processes, sexual dimorphism, hormonal regulation, autophagy, lipotoxicity, inflammation, mitochondrial metabolism, ionic channel remodeling, pericardial/intramyocardial fat, and lipid modifications. There has been a great deal of effort to identify and understand these mechanisms. Therefore, this Research Topic aims to improve our knowledge of how individual and combinations of these metabolic cues modulate the heart, following the goal of bettering cardiovascular health in patients worldwide.
The problem is that these mechanisms are complicated involving multiple steps. For example, metabolic syndrome, which is often defined by individual and multiple combinations of several pathologies (obesity, diabetes, inflammation, insulin resistance, hyperinsulinemia, hypercholesterolemia, and hypertriglyceridemia), is a critical contributor to the increasing prevalence of heart disease. This notion suggests that if we have a holistic knowledge of the molecular mechanisms of metabolic cues, we may be able to better develop interventions that will help decrease mortality and improve the quality of life and cardiovascular health of patients worldwide.
The goal of this Research Topic is to initiate discussions in the form of review papers, perspectives, in-silico and original articles involving recent advances from clinical and animal studies for how normal /impaired metabolic cues contribute to adverse electrical, structural, and neural modulation of cardiac function. We encourage investigations of mechanism-based signaling pathways involving: central and peripheral circadian clock signaling, stress-activated processes, sexual dimorphism, hormonal regulation, autophagy, lipotoxicity, inflammation, mitochondrial metabolism, ionic channel remodeling, pericardial/intramyocardial fat, and lipid modifications. There has been a great deal of effort to identify and understand these mechanisms. Therefore, this Research Topic aims to improve our knowledge of how individual and combinations of these metabolic cues modulate the heart, following the goal of bettering cardiovascular health in patients worldwide.
Keywords: Metabolism, Heart Disease, Sudden Cardiac Death, Metabolic Syndrome, Arrhythmias
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