About this Research Topic
This Research Topic will provide an overview of different types of PK inhibitors (PKIs) for different subclasses of PKs and explore the different strategies pursued from conventional targeting of the ATP-binding pocket and/or catalytic site to allosteric modulators.
We welcome original research and review articles from researchers involved in the whole sphere of PKI chemical biology. Topics included in this collection are;
• Chemical biological probes of KI efficacy and efficiency in vitro and in vivo
• Allosteric modulators of kinases
• ATP-competitive inhibitors
• KI that target cellular processes such as kinase degradation
• Understanding off-targets of KI and the mechanisms of disease resistance
• Biophysical/biochemical probes of PKI structure/interactions and dynamics
• Computer assisted design of KI, computational modelling of KI structure, KI dynamics and interactions with protein surfaces, machine learning and artificial intelligence (AI) approaches to KI design
Keywords: protein kinase inhibitor, protein/protein interaction, chemical probe, allosteric modulator, computer aided design
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.