About this Research Topic
Recent studies indicate that the unequal cancer burdens between the populations may be due in part to a complex biology that needs to be investigated to increase our basic understanding of cancer health disparities. For example, disproportionally higher rates of triple negative breast, colorectal, and prostate cancers exist in African Americans compared to other racial groups in the United States. Differences in tumor markers that modulate cancer initiation, promotion and/or progression and response to cancer therapy have been reported in various population groups. Scientific progress in the area of genomics, transcriptomics, metabolomics, bioinformatics and in the development of sophisticated computational biology tools has significantly contributed to our understanding of the critical role played by specific biological factors in cancer health disparities. For example high-throughput sequencing technology has made it possible for the discovery of single nucleotide polymorphisms at a genome level, hence enabling us to identify allelic variants of cancer susceptibility genes in human population subgroups. Advances in molecular technologies have also provided us with a new tool to critically assess changes in gene expression on a genome-wide basis, and to develop a holistic approach to the assessment of biologic responses to both cancer-causing agents and cancer therapeutics.
The overarching goal of this Research Topic is to present the recent advances and new developments in cancer health disparities. We are especially interested in research that has practical applications to understanding the nature and role played by biological factors in cancer health disparities. Equally important is research on innovative strategies to prevent/reduce and/or eliminate cancer health disparities. We welcome original research, systematic review, or review (including meta-analysis) articles focusing on the science of cancer health disparities. Topics of interest include the following:
• Novel in-vitro and in-vivo test systems designed to investigate cancer health disparities
• Novel therapeutic strategies to prevent/control cancer health disparities
• Genetic and epigenetic mechanisms in cancer health disparities
• Biomarkers of cancer health disparities
• Biological determinants of the disparity in cancer rates among various population groups
Keywords: cancer biology, cancer epidemiology, cancer control, cancer prevention, cancer disparities, minority health
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.