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17 news posts in Immune system

Neuroscience

08 Aug 2016

Seasonal allergies could change your brain

by Reeteka Sud, Frontiersin.org Hay fever may do more than give you a stuffy nose and itchy eyes — seasonal allergies may change the brain, says a study published in the open-access journal Frontiers in Cellular Neuroscience. Scientists found that brains of mice exposed to allergen actually produced more neurons than controls, they did this using a model of grass pollen allergy. The research team examined the hippocampus, the part of the brain responsible for forming new memories, and the site where neurons continue be formed throughout life. During an allergic reaction, there was an increase in the numbers of new neurons in the hippocampus, raising the question: what could be the consequences of allergies on memory? The formation and functioning of neurons is linked to the brain’s immune cells, the microglia.  Scientists used to believe that immune cells are not active unless there is a threat such as injury or disease. That belief went out the window when it was discovered that microglia are in fact very active even in healthy brains, sculpting connections between neurons. The research team monitored the functioning of microglia in allergic animals. To the scientists surprise, they found that the same allergic reaction that kicks the […]

Life sciences

29 Apr 2016

Advancing immunology and primary immunodeficiencies in the genomic era: The importance of being collaborative

We celebrate the day of Immunology with an interview with Sergio Rosenzweig, Deputy Chief of the Immunology Service at the Clinical Center, NIH and the Co-Director of the Primary Immunodeficiency Clinic, NIAID, NIH and Associate Editor for Frontiers in Immunology and for Frontiers in Pediatrics. After more than 20 years of experience as pediatrician and researcher in the field of primary immunodeficiencies, Dr Rosenzweig has no doubt: the best is yet to come.  “It is a fascinating time to be practicing medicine: if you take into consideration that the first genome was sequenced in 2003 and just six years later, in 2009, the first patient that diagnosed using next-generation sequencing, with a test cost reduction of 1 million times (from approximately 1billion dollars to 1 thousand dollars, that is just amazing” he said. Through omics technologies, the field of primary immunodeficiencies field is evolving at an exponential rate “We discover, on average, more than one new gene associated with primary immunodeficiencies per month”, he explained, “and this is teaching us so much: we thought we knew about those diseases, but now we are completely rethinking the way we study them.”   Can you tell us a bit more about primary […]