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Health

23 Feb 2016

STAFF PICK: Mutating to defeat malaria

This month’s Frontiers Staff Pick comes from Victor Kouassi. Victor is a Journal Operations Assistant and before joining us at Frontiers, was at the Francis Crick Institute in London where he conducted research on the immune responses of malaria. With his background in this field, he found the article “Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection” interesting.  It was published in Frontiers in Immunology late January 2016. Below is why he selected this article as his staff pick: There are over 100 species of Plasmodium, the parasite that causes malaria. These can infect many kinds of animals from monkeys, birds to lizards. This parasite has evolved an intricate life cycle by taking advantage of an invertebrate vector, the mosquito. A vertebrate host, like a human, is usually infected through a bite which transmits the parasite which goes straight to the liver. The parasite then divides into merozoites which are released into the blood. It is this form of the parasite that causes the symptoms of disease by entering red blood cells and eventually causing them to explode resulting in fevers, chills, headaches and, in worst case scenarios, coma, brain damage and miscarriages. Of the five species of Plasmodium that […]