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34 news posts in Genetics

Health

07 Oct 2016

Mental illness genetically linked to drug use and misuse

By Tania Fitzgeorge-Balfour, Frontiers Science Writer A person’s genetic risk for psychiatric disorders is related to his or her vulnerability to substance use and misuse There are many reports of drug use leading to mental health problems, and we all know of someone having a few too many drinks to cope with a bad day. Many people who are diagnosed with a mental health disorder indulge in drugs, and vice versa. As severity of both increase, problems arise and they become more difficult to treat. But why substance involvement and psychiatric disorders often co-occur is not well understood. In addition to environmental factors, such as stress and social relationships, a person’s genetic make-up can also contribute to their vulnerability to drug use and misuse as well as mental health problems. So could genetic risk for mental illness be linked to a person’s liability to use drugs? This question has been addressed in a new study, published in the open-access journal Frontiers in Genetics. “Our research shows that if someone is genetically predisposed towards having mental illness, they are also prone to use licit and illicit substances and develop problematic usage patterns,” says Caitlin E. Carey, a PhD student in the […]

Frontiers news

06 Aug 2016

Most viewed Genetics articles in July 2016

Spatial and Temporal Variation in Selection of Genes Associated with Pearl Millet Varietal Quantitative Traits In situ Cédric Mariac, Issaka S. Ousseini, Abdel-Kader Alio, Hélène Jugdé, Jean-Louis Pham, Gilles Bezançon, Joelle Ronfort, Luc Descroix and Yves Vigouroux* Genetic Diversity and Molecular Evolution of a Violaxanthin De-epoxidase Gene in Maize Jing Xu, Zhigang Li, Haorui Yang, Xiaohong Yang, Cuixia Chen* and Hui Li* Analysis of Variance Components for Genetic Markers with Unphased Genotypes Tao Wang* Profile of the Spleen Transcriptome in Beef Steers with Variation in Gain and Feed Intake Amanda K. Lindholm-Perry*, Rebecca J. Kern, Brittney N. Keel, Warren M. Snelling, Larry A. Kuehn and Harvey C. Freetly Maintaining Genome Stability in Defiance of Mitotic DNA Damage Stefano Ferrari* and Christian Gentili Spatial Genome Organization and Its Emerging Role as a Potential Diagnosis Tool Karen J. Meaburn* DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets Adan Pinto-Fernandez* and Benedikt M. Kessler

Frontiers news

03 Jul 2016

Most viewed Genetics articles in June 2016

The Genetic Contribution of West-African Ancestry to Protection against Central Obesity in African-American Men but Not Women: Results from the ARIC and MESA Studies Yann C. Klimentidis*, Amit Arora, Jin Zhou, Rick Kittles and David B. Allison Random Projection for Fast and Efficient Multivariate Correlation Analysis of High-Dimensional Data: A New Approach Claudia Grellmann*, Jane Neumann, Sebastian Bitzer, Peter Kovacs, Anke Tönjes, Lars T. Westlye, Ole A. Andreassen, Michael Stumvoll, Arno Villringer and Annette Horstmann Comparative Epigenomic Profiling of the DNA Methylome in Mouse and Zebrafish Uncovers High Interspecies Divergence Chi Zhang, Yujin Hoshida and Kirsten C. Sadler* The Genetic Architecture of Barley Plant Stature Ahmad M. Alqudah*, Ravi Koppolu, Gizaw M. Wolde, Andreas Graner and Thorsten Schnurbusch* Deriving Gene Networks from SNP Associated with Triacylglycerol and Phospholipid Fatty Acid Fractions from Ribeyes of Angus Cattle Justin W. Buchanan, James M. Reecy, Dorian J. Garrick, Qing Duan, Don C. Beitz, James E. Koltes, Mahdi Saatchi, Lars Koesterke and Raluca G. Mateescu* Association of a SNP in SLC35F3 Gene with the Risk of Hypertension in a Chinese Han Population Xiao-Li Zang, Wei-Qing Han, Feng-Ping Yang, Kai-Da Ji, Ji-Guang Wang, Ping-Jin Gao, Guang He* and Sheng-Nan Wu* Global and Site-Specific Changes in 5-Methylcytosine and 5-Hydroxymethylcytosine after Extended Post-mortem Interval […]

Life sciences

05 Jun 2016

West African genes lower the risk of obesity in men, suggests study

By Michiel Dijkstra, science writer The obesity epidemic affects women and men of every ethnic group in the United States, but strong gender and racial disparities in the risk of overweight and obesity exist. African American women are currently more at risk than any other group in the United States: 82.1% of African American women are overweight or obese (defined as having a BMI of 25 or higher), compared to 76.2% of Hispanic women and 64.6% of Caucasian women, according to the 2011-2012 National Health and Nutrition Examination Survey (NHANES). Socioeconomic factors, such as inequalities in access to healthcare, healthy food, and safe places to exercise, are known to be important causes of these and other racial disparities in health characteristics. In contrast, “only” 69.1% of African American men are overweight or obese – a percentage that is still alarmingly high in absolute terms, but lower than the percentages for Caucasian men (73.2%), and Hispanic men (77.9%), according to the NHANES data. A similar pattern has been reported for type-2 diabetes, a disease strongly associated with overweight and obesity: according to a 2007 study in The American Journal of Public Health, the incidence of diabetes is higher among African American […]

Frontiers news

04 Jun 2016

Most viewed Genetics articles in May 2016

Population Stratification in the Context of Diverse Epidemiologic Surveys Sans Genome-Wide Data Matthew T. Oetjens, Kristin Brown-Gentry, Robert Goodloe, Holli H. Dilks and Dana C. Crawford* Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases Arsen Arakelyan*, Lilit Nersisyan, Martin Petrek, Henry Löffler-Wirth and Hans Binder Recursive Indirect-Paths Modularity (RIP-M) for Detecting Community Structure in RNA-Seq Co-expression Networks Bahareh Rahmani, Michael T. Zimmermann, Diane E. Grill, Richard B. Kennedy, Ann L. Oberg, Bill C. White, Gregory A. Poland and Brett A. McKinney* Elementary Vectors and Conformal Sums in Polyhedral Geometry and their Relevance for Metabolic Pathway Analysis Stefan Müller* and Georg Regensburger TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients Ann R. Halvorsen, Laxmi Silwal-Pandit, Leonardo A. Meza-Zepeda, Daniel Vodak, Phuong Vu, Camilla Sagerup, Eivind Hovig, Ola Myklebost, Anne-Lise Børresen-Dale, Odd T. Brustugun and Åslaug Helland* Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide Polymorphisms Associated with Nonsyndromic Cleft Lip with or without Cleft Palate Amit K. Mitra, Holly A. F. Stessman, Robert J. Schaefer, Wen Wang, Chad L. Myers, Brian G. Van Ness and Soraya Beiraghi* Genes with a Combination of Over-Dominant and Epistatic Effects Underlie Heterosis in Growth of Saccharomyces cerevisiae at High Temperature Rachel Shapira and Lior […]

Life sciences

13 May 2016

Using precision-genetics in pigs to beat cancer

Because of their similarities to people, using new technology in pigs turns up as a valuable alternative to rodent models of cancer. By Mônica Favre, Frontiers Staff Science Writer The numbers are staggering: more than 40 % is the lifetime risk of developing cancer in the U.S., with only 66 % survival-rates 5 years after diagnosis, for all types of cancer. Trends suggest that in 2015, over 1.6 million new cases were diagnosed in the U.S., with over 580,000 deaths in consequence. These numbers emphasize the need to better understand and treat the various forms of the disease, but mouse models usually used in cancer research have given us limited answers.  However, Senior Scientist Adrienne Watson and colleagues at Recombinetics and the University of Minnesota, say that pigs may turn out to be the best alternative models. “Many organ systems vary so greatly between rodents and humans that certain types of cancer cannot be accurately modelled,” says Watson, despite the major role mouse models have played in our understanding of the disease. The authors conclude that the five deadliest cancers in the U.S. cannot be modeled in rodents, or have ineffective models for identification of treatments that translate to the […]

Frontiers news

06 May 2016

Most viewed Genetics articles in April 2016

Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines Darius Wlochowitz*, Martin Haubrock, Jetcy Arackal, Annalen Bleckmann, Alexander Wolff, Tim Beißbarth, Edgar Wingender and Mehmet Gültas* Paths of Heritable Mitochondrial DNA Mutation and Heteroplasmy in Reference and gas-1 Strains of Caenorhabditis elegans Riana I. Wernick, Suzanne Estes, Dana K. Howe and Dee R. Denver* Identification of a Bitter-Taste Receptor Gene Repertoire in Different Lagomorphs Species Ana M. Ferreira*, Andreia T. Marques, Luca Fontanesi, Carl-Gustaf Thulin, Elvira Sales-Baptista, Susana S. Araújo and André M. Almeida Identification of QTL on Chromosome 18 Associated with Non-Coagulating Milk in Swedish Red Cows Sandrine I. Duchemin*, Maria Glantz, Dirk-Jan de Koning, Marie Paulsson and Willem F. Fikse Mouse and Human Genetic Analyses Associate Kalirin with Ventral Striatal Activation during Impulsivity and with Alcohol Misuse Yolanda Peña-Oliver*, Fabiana M. Carvalho, Sandra Sanchez-Roige, Erin B. Quinlan, Tianye Jia, Tom Walker-Tilley, Stuart L. Rulten, Frances M. G. Pearl, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Christian Büchel, Patricia J. Conrod, Herta Flor, Jürgen Gallinat, Hugh Garavan, Andreas Heinz, Penny Gowland, Marie-Laure Paillere Martinot, Tomáš Paus, Marcella Rietschel, Trevor W. Robbins, Michael N. Smolka, Gunter Schumann, David N. Stephens for the IMAGEN Consortium Boolean Modeling Reveals the Necessity […]

Frontiers news

08 Apr 2016

Most viewed Genetics articles in March 2016

A Consensus Network of Gene Regulatory Factors in the Human Frontal Lobe Stefano Berto*, Alvaro Perdomo-Sabogal, Daniel Gerighausen, Jing Qin and Katja Nowick* Computational Detection of Stage-Specific Transcription Factor Clusters During Heart Development Sebastian Zeidler*, Cornelia Meckbach, Rebecca Tacke, Farah S. Raad, Angelica Roa, Shizuka Uchida, Wolfram-Hubertus Zimmermann, Edgar Wingender and Mehmet Gültas Global Intersection of Long Non-Coding RNAs with Processed and Unprocessed Pseudogenes in the Human Genome Michael J. Milligan, Erin Harvey, Albert Yu, Ashleigh Morgan, Daniela-Lee Smith, Eden Zhang, Jonathan Berengut, Jothini Sivananthan, Radhini Subramaniam, Aleksandra Skoric, Scott Collins, Caio Damski, Kevin V. Morris and Leonard Lipovich* EM Adaptive LASSO – A Multilocus Modeling Strategy for Detecting SNPs Associated with Zero-Inflated Count Phenotypes Himel Mallick and Hemant K. Tiwari* Genome-Wide Study of Response to Platinum, Taxane, and Combination Therapy in Ovarian Cancer: In vitro Phenotypes, Inherited Variation, and Disease Recurrence Brooke L. Fridley*, Taraswi M. Ghosh, Alice Wang, Rama Raghavan, Junqiang Dai, Ellen L. Goode and Jatinder K. Lamba Microsomal Omega-3 Fatty Acid Desaturase Genes in Low Linolenic Acid Soybean Line RG10 and Validation of Major Linolenic Acid QTL Yarmilla Reinprecht* and K. Peter Pauls A Quantitative Approach to Analyzing Genome Reductive Evolution Using Protein-Protein Interaction Networks: A Case Study of Mycobacterium leprae Richard O. Akinola, Gaston […]

Frontiers news

05 Mar 2016

Most viewed Genetics articles in February 2016

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics Dominic Holland*, Yunpeng Wang, Wesley K. Thompson, Andrew Schork, Chi-Hua Chen, Min-Tzu Lo, Aree Witoelar, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Enhancing Neuro Imaging Genetics through Meta Analysis Consortium, Thomas Werge, Michael O’Donovan, Ole A. Andreassen and Anders M. Dale Identification of Metabolic Pathway Systems Sepideh Dolatshahi and Eberhard O. Voit* Structural and Dynamic Characterization of the C313Y Mutation in Myostatin Dimeric Protein, Responsible for the “Double Muscle” Phenotype in Piedmontese Cattle Silvia Bongiorni, Alessio Valentini and Giovanni Chillemi* Genomic-Based Optimum Contribution in Conservation and Genetic Improvement Programs with Antagonistic Fitness and Productivity Traits Enrique Sánchez-Molano*, Ricardo Pong-Wong and Georgios Banos Cellular Senescence as the Causal Nexus of Aging Naina Bhatia-Dey, Riya R. Kanherkar, Susan E. Stair, Evgeny O. Makarev and Antonei B. Csoka* Strategies for Integrated Analysis of Genetic, Epigenetic, and Gene Expression Variation in Cancer: Addressing the Challenges Louise B. Thingholm*, Lars Andersen, Enes Makalic, Melissa C. Southey, Mads Thomassen and Lise Lotte Hansen Genetic Susceptibility to Vitiligo: GWAS Approaches for Identifying Vitiligo Susceptibility Genes and Loci Changbing Shen, Jing Gao, Yujun Sheng, Jinfa Dou, Fusheng Zhou, Xiaodong Zheng, Randy Ko, Xianfa Tang, Caihong Zhu, […]

Frontiers news

06 Feb 2016

Most viewed Genetics articles in January 2016

Decoding Cellular Dynamics in Epidermal Growth Factor Signaling Using a New Pathway-Based Integration Approach for Proteomics and Transcriptomics Data Astrid Wachter* and Tim Beissbarth An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3′-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients Marelize Swart, Jonathan Evans, Michelle Skelton, sandra castel, Lubbe Weisner, Peter John Smith and Collet Dandara* Using centromere mediated genome elimination to elucidate the functional redundancy of candidate telomere binding proteins in Arabidopsis thaliana. Karel Riha* and Nick Fulcher Stress-induced accumulation of DcAOX1 and DcAOX2a transcripts coincides with critical time point for structural biomass prediction in carrot primary cultures (Daucus carota L.) Maria Doroteia Campos, Amaia Nogales, Hélia Guerra Cardoso*, Sarma Rajeev Kumar, Tânia Nobre, Ramalingam Sathishkumar and Birgit Arnholdt-Schmitt* Milk bottom-up proteomics: method optimisation. Delphine Vincent*, Vilnis Ezernieks, Aaron Elkins, Nga Nguyen, Peter J. Moate, Benjamin G. Cocks and Simone Rochfort A Quantitative Assessment of Factors Affecting the Technological Development and Adoption of Companion Diagnostics Dee Luo, James A Smith, Nick A Meadows, Katie Manescu, Kim Bure, Benjamin Davies, Rob Horne, David L DiGiusto and David A Brindley* Advanced In vivo Use of CRISPR/Cas9 and Anti-Sense DNA Inhibition for Gene Manipulation in the Brain Brandon J. Walters, Amber B. Azam, Colleen J. […]

Frontiers news

08 Jan 2016

Most viewed Genetics articles in December 2015

Transfection of microRNA Mimics Should Be Used with Caution Hyun Yong Jin, Alicia Gonzalez-Martin, Ana V. Miletic, Maoyi Lai, Sarah Knight, Mohsen Sabouri-Ghomi, Steven R. Head, Matthew S. Macauley, Robert C. Rickert and Changchun Xiao* Addressing Bias in Small RNA Library Preparation for Sequencing: A New Protocol Recovers microRNAs that Evade Capture by Current Methods Jeanette Baran-Gale*, C. Lisa Kurtz, Michael R. Erdos, Christina Sison, Alice Young, Emily E. Fannin, Peter S. Chines and Praveen Sethupathy* Overexpression of the Heterochromatinization Factor BAHD1 in HEK293 Cells Differentially Reshapes the DNA Methylome on Autosomes and X Chromosome. Emanuele Libertini, Alice Lebreton, Goran Lakisic, Marie-Agnès Dillies, Stephan Beck, Jean-Yves Coppée, Pascale Cossart and Hélène Bierne* Biased Allele Expression and Aggression in Hybrid Honeybees May Be Influenced by Inappropriate Nuclear-Cytoplasmic Signaling Joshua D. Gibson*, Miguel E. Arechavaleta-Velasco, Jennifer M. Tsuruda and Greg J. Hunt Extent of Linkage Disequilibrium and Effective Population Size in Four South African Sanga Cattle Breeds Sithembile O. Makina*, Jeremy F. Taylor, Este Van Marle-Koster, Farai C. Muchadeyi, Mahlako L. Makgahlela, Michael D. MacNeil and Azwihangwisi Maiwashe Differential Occurrence of Interactions and Interaction Domains in Proteins Containing Homopolymeric Amino Acid Repeats Ilaria Pelassa and Ferdinando Fiumara* Targeted Analysis Reveals an Important Role of JAK-STAT-SOCS Genes for Milk Production Traits in […]

Frontiers news

02 Dec 2015

Most viewed Genetics articles in November 2015

Identification of Low-Confidence Regions in the Pig Reference Genome (Sscrofa10.2) Amanda Warr, Christelle Robert, David Hume, Alan L. Archibald, Nader Deeb and Mick Watson*   Mapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Marina Lizio, Yuri Ishizu, Masayoshi Itoh, Timo Lassmann, Akira Hasegawa, Atsutaka Kubosaki, Jessica Severin, Hideya Kawaji,Yukio Nakamura, the FANTOM consortium, Harukazu Suzuki, Yoshihide Hayashizaki, Piero Carninci and Alistair R. R. Forrest*   riboFrame: An Improved Method for Microbial Taxonomy Profiling from Non-Targeted Metagenomics Matteo Ramazzotti*, Luisa Berná, Claudio Donati and Duccio Cavalieri*   Genome-Wide Screening of mRNA Expression in Leprosy Patients Andrea de Faria F. Belone, Patrícia S. Rosa, Ana P. F. Trombone, Luciana R. V. Fachin, Cássio C. Guidella, Somei Ura, Jaison A.Barreto, Mabel G. Pinilla, Alex F. de Carvalho, Dirce M. Carraro, Fernando A. Soares and Cleverson T. Soares*   Evaluation of Genome Wide Association Study Associated Type 2 Diabetes Susceptibility Loci in Sub Saharan Africans Adebowale A. Adeyemo, Fasil Tekola-Ayele, Ayo P. Doumatey, Amy R. Bentley, Guanjie Chen, Hanxia Huang, Jie Zhou, Daniel Shriner, Olufemi Fasanmade, Godfrey Okafor, Benjamin Eghan Jr., Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Abdel Elkahloun, Settara Chandrasekharappa, Samuel Owusu, Albert Amoah, Joseph Acheampong, […]

Frontiers news

05 Nov 2015

Most viewed Genetics articles in October 2015

Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans Devon Chandler-Brown, Haeri Choi, Shirley Park, Billie R. Ocampo, Shiwen Chen, Anna Le, George L. Sutphin, Lara S. Shamieh, Erica D. Smith and Matt Kaeberlein*   Genetic markers as a predictive tool based on statistics in medical practice: ethical considerations through the analysis of the use of HLA-B*27 in rheumatology in France Hélène Colineaux*, Adeline Ruyssen-Witrand and Anne Cambon-Thomsen   Association of SLC2A9 genotype with phenotypic variability of serum urate in pre-menopausal women Ruth K. Topless, Tanya J. Flynn, Murray Cadzow, Lisa K. Stamp, Nicola Dalbeth, Michael A. Black and Tony R. Merriman*   Phenotypic variance explained by local ancestry in admixed African Americans Daniel Shriner, Amy R. Bentley, Ayo P. Doumatey, Guanjie Chen, Jie Zhou, Adebowale Adeyemo and Charles N. Rotimi*   Cryptic relatedness in epidemiologic collections accessed for genetic association studies: experiences from the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) study and the National Health and Nutrition Examination Survey Jennifer Malinowski, Robert Goodloe, Kristin Brown-Gentry and Dana C. Crawford*   Mechanisms of mutational robustness in transcriptional regulation Joshua L. Payne* and Andreas Wagner   Moving from capstones towards cornerstones: successes and challenges in applying systems biology to identify […]

Frontiers news

03 Oct 2015

Most viewed Genetics articles in September 2015

Selection and validation of potato candidate genes for maturity corrected resistance to Phytophthora infestans based on differential expression combined with SNP association and linkage mapping Meki S. Muktar*, Jens Lübeck, Josef Strahwald and Christiane Gebhardt Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways Suleiman H. Suleiman, Mahmoud E. Koko, Wafaa H. Nasir, Ommnyiah Elfateh, Ubai K. Elgizouli, Mohammed O. E. Abdallah, Khalid O. Alfarouk, Ayman Hussain, Shima Faisal, Fathelrahman M. A. Ibrahim, Maurizio Romano, Ali Sultan, Lawrence Banks, Melanie Newport, Francesco Baralle, Ahmed M. Elhassan, Hiba S. Mohamed and Muntaser E Ibrahim* How spatio-temporal habitat connectivity affects amphibian genetic structure Alexander G. Watts*, Peter E. Schlichting, Shawn M. Billerman, Brett R. Jesmer, Steven Micheletti, Marie-Josee Fortin, W. Chris Funk, Paul Hapeman, Erin Muths and Melanie A. Murphy* Molecular footprinting of skeletal tissues in the catshark Scyliorhinus canicula and the clawed frog Xenopus tropicalis identifies conserved and derived features of vertebrate calcification Sebastien Enault, David N. Muñoz, Willian T. A. F. Silva, Véronique Borday-Birraux, Morgane Bonade, Silvan Oulion, Stéphanie Ventéo, Sylvain Marcellini* and Melanie Debiais-Thibaud* Polymorphisms in Toll-like receptor genes are associated with vitiligo Tanel Traks*, Maris Keermann, Maire Karelson, Ranno Rätsep, Ene Reimann, Helgi Silm, Eero […]