455 news posts in Health

Health

15 Feb 2023

Brain changes in fighter pilots may cast light on astronauts during space travel

By Conn Hastings, science writer Understanding the effects of space travel will help us to plan long-haul space flights, but getting access to astronauts is not easy. A new study investigates whether F16 fighter pilots demonstrate brain connectivity changes that could be expected in astronauts, based on similar exposure to changes in g-forces. The study found that the pilots showed key changes in brain connectivity and they may function as suitable test subjects to learn more about space travel. One cannot explore the profound mysteries of space without being changed by it. This is the message underlying a new study in Frontiers in Physiology. The study examined the brains of F16 fighter pilots, which have a lot in common with those of astronauts in terms of adapting to altered gravity levels and rapidly processing conflicting sensory information. MRI scans revealed that pilots with more flight experience showed specific brain connectivity patterns in areas related to processing sensorimotor information. They also showed differences in brain connectivity compared with non-pilots. The study will help us to understand the effects of space flight on the brain and may aid in providing better training programs for pilots or astronauts. Spaceships: a rollercoaster for the […]

Health

14 Feb 2023

Cocaine addiction makes the brain age faster, suggests study

By Mischa Dijkstra, Frontiers science writer A new study finds evidence from the DNA methylome that the biological age – different from the chronological age – of cells in Brodmann Area 9 of the prefrontal cortex might be greater in people with cocaine use disorder. This suggests that cocaine abuse makes these cells age faster according to the ‘epigenetic clock’. The authors also find differences in methylation in 20 genes, mainly involved in regulation of the activity of neurons and their connectivity. This post-mortem study is one of the first to directly look at the methylome of brain cells in human subjects with cocaine use disorder, rather than in rodents. Scientists tend to view substance addiction as primarily a disease of the brain. When we enjoy sex, food, music, or hobbies, regions of our brain within the reward pathway are flooded with pleasure-inducing dopamine. Drugs like cocaine copy this effect, except up to ten times more strongly. Healthy brains aren’t at the mercy of such dopamine rushes, however: there, the prefrontal cortex weighs options and can decide to forgo pleasurable activities when it’s not the time or place. In contrast, such ‘inhibitory control’ is impaired in the addicted brain, making […]

Health

09 Feb 2023

Human test subjects may no longer be needed for mosquito bite trials thanks to invention of new biomaterial

by Angharad Brewer Gillham, Frontiers science writer Image/Shutterstock.com Studies on mosquito feeding behavior are crucial to fighting malaria, dengue, and other mosquito-borne pathogens – but traditionally, they require humans or animals to act as meals for the mosquitoes. Scientists have developed a biomaterial which mimics skin, right down to blood under the surface, to make studies on mosquito feeding easier to run. Mosquitoes: the world’s deadliest animal. These tiny flying insects are vectors for dengue fever, yellow fever, Zika, malaria, and many other illnesses which affect millions of people around the world, with a significant morbidity and mortality burden. Because they spread disease when they bite people, understanding their feeding behavior is critical to reducing the harm they do. But how to study mosquito feeding behavior without giving them a live meal? A collaboration between Rice University and Tulane University in the US has developed a biomaterial which could eliminate the need for human volunteers or animal subjects in mosquito bite research. “Several groups are dedicated to finding ways to stop mosquitoes from biting, but bringing new repellents to market is challenging,” said Prof Omid Veiseh, Rice University, corresponding author of the study published in Frontiers in Bioengineering and Biotechnology. […]

Health

01 Feb 2023

Medicines that modify the circadian clock might help heal scars more cleanly

by Angharad Brewer Gillham, Frontiers science writer Image/Shutterstock.com Scientists determined that compounds which play key roles in both collagen synthesis and circadian management can be used to make wounds on cell samples heal more quickly and effectively, offering promise for treatments to prevent problem scarring in the future. Healing often leaves a scar. But the role of the scar itself in healing is often underestimated: a scar that doesn’t heal cleanly can be painful or upsetting or affect the range of movement of the affected body part. It may even require further surgical treatment. Now, scientists based at the University of California Los Angeles have found that compounds which target the circadian clock and affect the synthesis of collagen — a protein which is important for skin repair — could improve scar healing. “Our aim was to find compounds that were able to increase the rate at which dermal wounds heal while mitigating the formation of hypertrophic scars,” said Dr Akishige Hokugo, corresponding author of a study published to Frontiers in Medicine. “Scars can result in emotional distress following normal wound healing by serving as permanent reminders of the initial incident. Accounting for additional revision procedures, extended hospital stays, and […]

Health

30 Jan 2023

Five articles you need to check out on the future of surgery

By Colm Gorey, Science Communications Manager Image: Shutterstock.com From robotic surgeons to ultra-detailed imaging technology, the field of surgery is going through rapid change. To help us understand what the latest research is in this world of dissection, Frontiers highlights just some of the top articles we’ve recently published. The robot takeover of the workforce is nowhere more apparent than in the medical world, where many delicate surgical procedures are either aided by a robotic assistant, or in some cases performed entirely by a machine. But advances in surgery are not just limited to robotics, with new imaging technologies helping us peer inside the human body like never before. Here are five recent Frontiers articles published as part of the research topic ‘Anatomical Fundamentals of Advanced Surgical Techniques’ that may greatly influence even more breakthroughs in the future. Robotic pelvic exenteration for gynecologic malignancies, anatomic landmarks, and surgical steps: a systematic review Pelvic exenteration – a surgical operation to remove multiple organs in the pelvis – represents the last resort procedure for patients with advanced primary or recurrent gynecological malignancy, such as endometrial cancer. However, since 2009, the advent of robotic surgery resulted in a new spur to the […]

Health

30 Jan 2023

$1 smart glove could help prevent dangerous births by sensing fetal position

by Conn Hastings, science writer Image/Shutterstock.com Low-resource regions often lack the medical technology to assess when things are going wrong during birth. A new study has revealed an inexpensive sensing glove that can transmit data on fetal position and force applied to the fetal head. The technology could be invaluable in identifying obstructed birth in low-resource regions, providing real-time data on a smartphone app. Can inexpensive technologies provide a helping hand during birth? A new study in open-access journal Frontiers in Global Women’s Health has revealed a low-cost sensing glove that could do just that. The researchers created the device to assist healthcare staff in identifying fetal position and the force applied to the fetal head during labor, factors that can contribute to obstructed labor and poor birth outcomes. The technology can provide real-time data during vaginal examinations, potentially improving birth outcomes in low-resource regions. Birth outcomes in low-resource regions When labor is not going as it should, clinicians can use a wide array of medical technologies to determine what is wrong. However, in low- and middle-income countries, these technologies and skilled staff who can use them are not always available. The researchers behind this latest study reported that 98% […]

Health

25 Jan 2023

Using running to escape everyday stresses may lead to exercise dependence instead of mental wellbeing

By Angharad Brewer Gillham, Frontiers science writer Image/Shutterstock.com Different kinds of escapism can motivate people to take part in running, but using running to escape from negative experiences rather than using it to escape to positive ones may lead to exercise dependence. Recreational running offers a lot of physical and mental health benefits – but some people can develop exercise dependence, a form of addiction to physical activity which can cause health issues. Shockingly, signs of exercise dependence are common even in recreational runners. A study published in Frontiers in Psychology investigated whether the concept of escapism can help us understand the relationship between running, wellbeing, and exercise dependence. “Escapism is an everyday phenomenon among humans, but little is known regarding its motivational underpinnings, how it affects experiences, and the psychological outcomes from it,” said Dr Frode Stenseng of the Norwegian University of Science and Technology, lead author of the paper. Running to explore or to evade? “Escapism is often defined as ‘an activity, a form of entertainment, etc. that helps you avoid or forget unpleasant or boring things’. In other words, many of our everyday activities may be interpreted as escapism,” said Stenseng. “The psychological reward from escapism is […]

Health

17 Jan 2023

Healthy Eating: Article Collections on Nutrition

What is a healthy diet? Is gluten free actually better for you? Are there good fats? Find the answers to your biggest research questions on nutrition with our top article collections about what to put on your plate. With collective views of over 1.2 million, researchers explored topics spanning from antioxidants and food additives to sustainable diets and the rise of flexitarianism. Article Collections: Mediterranean diet 4 articles | 62,000 views Uncovering the health promoting effects of traditional Mediterranean diets, including lower risk of chronic degenerative diseases, neurodegenerative disorders, and certain types of cancer Sustainable diets 43 articles | 90,000 views Examining a diet that is measured by calorie or nutrient content as well as by the quality and environmental footprint of the ingredients used Flexitarianism 6 articles | 167,000 views Exploring the health implications of flexitarianism, referring to an individual who follows a primarily but not strictly vegetarian diet, occasionally eating meat or fish Fermented foods 19 articles | 190,000 views Understanding the viability of probiotic bacteria in fermented foods has opened up possibilities of producing new ingredients for nutritionally optimized foods, which can promote consumers’ health through microbial activities in the gut Dietary antioxidants 6 articles | 41,000 […]

Health

17 Jan 2023

From pylons to pandas: 5 Frontiers articles you won’t want to miss

by Angharad Brewer Gillham, Frontiers science writer Image/Shutterstock.com At Frontiers, we bring some of the world’s best research to a global audience. But with tens of thousands of articles published each year, many often fly under the radar. Here are just five amazing papers you may have missed. Building better-looking pylons Pylons help support essential amenities – but they can be an eyesore. Italian scientists led by Dr Luca Di Angelo at University of L’Aquila investigated the best way to build a pylon with less visual impact on the landscape. As visual impact is subjective, reducing it requires consultation with residents who will see the pylons every day. But designs invented by residents without technical knowledge may not be able to meet safety standards. Di Angelo and colleagues used the development of new electrical pylons in the coastal regions of Italy to test a novel method of integrating visual impact minimization with the design process. They identified shapes which were related to the geography and culture of the area and streamlined enough for pylon design, and surveyed Italians from different coastal regions to determine which shapes were considered most recognizable and representative. A sail was chosen, and models were developed […]

Health

12 Jan 2023

Simple blood test shows promise for screening common and dangerous pregnancy complications

By Angharad Brewer Gillham, Frontiers science writer Image/Shutterstock.com Scientists find that short-chain fatty acids in blood can be used as biomarkers in testing for dangerous pregnancy complications such as pre-eclampsia, gestational diabetes and intrahepatic cholestasis of pregnancy. Scientists at Ningbo University, China have identified biomarkers that could provide an early warning system for three common and dangerous pregnancy complications: pre-eclampsia, gestational diabetes, and a liver condition called intrahepatic cholestasis. All three conditions are dangerous; early diagnosis and treatment is key to preventing poor outcomes and lifelong consequences. Their causes are not fully understood, and nor is their connection to the gut microbiome, which is affected by pregnancy and pregnancy-related conditions. A team led by Dr Siqian Chen at the Affiliated Hospital of Medical School decided to investigate whether specific changes in the microbiome — detected using levels of short-chain fatty acids, metabolites which are produced following the fermentation of microbiota — could be used as biomarkers for pregnancy complications. “We analyzed and correlated the distribution of short-chain fatty acids during normal pregnancy and during three specific types of complicated pregnancy, gestational diabetes, pre-eclampsia, and intrahepatic cholestasis,” said Dr Rongrong Xuan, senior author of the study, published today in Frontiers in […]

Health

09 Jan 2023

Eating almonds daily boosts exercise recovery molecule by 69% among ‘weekend warriors’

By Mischa Dijkstra, Frontiers science writer A new randomized controlled trial showed that participants who daily ate 57g almonds over four weeks had a 69% higher level of the beneficial oxylipin molecule 12,13-dihydroxy-9Z-octadecenoic acid in their blood after a 90 minute session of eccentric exercise than control volunteers. In contrast, they had a 40% lower level of the mildly toxic 9,10-Dihydroxy-12-octadecenoic acid in their blood after exercise than control participants. The authors conclude that daily consumption of almonds changes the metabolism to recover faster after strenuous exercise. For those who exercise regularly, eating almonds each day might be the ideal new year’s resolution. A randomized controlled trial in Frontiers in Nutrition showed that female and male participants who ate 57g almonds daily for one month had more of the beneficial fat 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME) in their blood immediately after a session of intense exercise than control participants. This molecule, a so-called oxylipin (oxidized fat) is synthetized from linoleic acid by brown fat tissue, and has a beneficial effect on metabolic health and energy regulation. Corresponding author Dr David C Nieman, a professor and director of the Appalachian State University Human Performance Laboratory at the North Carolina Research Campus, said: “Here […]

Health

20 Dec 2022

Lonely heart-failure patients face worse outcomes than sociable peers

by Tania Fitzgeorge-balfour, science writer Social frailty, which includes the loss of social roles, social networks, and social activities, is widely identified as a risk to healthy aging. A new study is the first to show a close association between the loss of perceived social role amongst friends and family and poor clinical outcomes for older heart failure patients. These findings suggest that social engagement and activities should form part of the aftercare program for these patients. Older heart failure patients who feel that they have lost their social role amongst friends and family are more likely to suffer poor clinical outcomes. This is the finding of a new study in Frontiers in Cardiovascular Medicine that has examined the specific aspects of social interaction that can lead to a poor prognosis for these patients. “We are the first to show a close association between the loss of perceived social role and long-term poor clinical outcomes in older heart failure patients,” said Dr Satoshi Katano, first author of this research, based at Sapporo Medical University Hospital, Sapporo, Japan. “Our study highlights the real need to develop a management program that includes a social approach to the care of these patients.” Read […]

Health

13 Dec 2022

The (un)fair allocation of scarce vaccines and how maths can provide a solution

By Prof Carlos Alós-Ferrer Prof Carlos Alós-Ferrer. Image: Nomis Foundation The Covid-19 global vaccine roll-out is considered one of the greatest achievements in modern medical history, saving hundreds of thousands of lives. However, it was marred by decisions that saw those most in need of a vaccine in some countries wait too long, while those perceived to be least at risk getting them first. Now, Prof Carlos Alós-Ferrer of the University of Zurich writes about how he and his colleagues’ latest research in Frontiers in Public Health shows that one maths procedure can ensure a fair distribution of scarce vaccines across the globe. Remember when Covid-19 vaccines first became available? After many months of lockdowns and increasing casualty rates, people across the planet were allowed to exhale a collective sigh of relief. However, as is always the case when new vaccines are developed, there were not enough doses for all who wanted them. Rationing had to be imposed. Unfortunately, the rationing procedures violated elementary ethical principles, which might have led to some elderly and at-risk patients being neglected while younger, healthier citizens were already vaccinated. How did it go wrong? Vaccine acquisition and allocation across the world was as centralized […]

Health

07 Dec 2022

Could new cancer drugs come from potatoes and tomatoes?

by Angharad Brewer Gillham, Frontiers science writer Image/Shutterstock.com Polish scientists revealed the potential for new cancer drugs to be formulated from bioactive compounds found in plants from the genus Solanum, like potatoes and aubergines. Everyone knows someone who has had cancer. In 2020, around 19m new cases — and around 10m deaths — were registered worldwide. Treatments are improving all the time but can damage healthy cells or have severe side-effects which are hard on patients; in the search for new, more targeted cancer drugs, traditional medicine offers many possible candidates. A team of Polish scientists led by Magdalena Winkiel at Adam Mickiewicz University, publishing today in Frontiers in Pharmacology, reviewed the bioactive compounds called glycolalkaloids that are found in many vegetables that are household names, like potatoes and tomatoes, to demonstrate their potential to treat cancer. “Scientists around the world are still searching for the drugs which will be lethal to cancer cells but at the same time safe for healthy cells,” said Winkiel. “It is not easy despite the advances in medicine and powerful development of modern treatment techniques. That is why it might be worth going back to medicinal plants that were used years ago with success […]

Health

05 Dec 2022

Scientists find inorganic food additives might make babies more vulnerable to allergies

By Angharad Brewer Gillham, Frontiers science writer Image/Shutterstock.com Inorganic nanoparticles used to help process food may be crossing the placental barrier and getting into breastmilk, potentially damaging intestinal regulation and compromising babies’ oral tolerance, predisposing them to food allergies. Nanotechnologies have revolutionized food technology with changes to food production, manufacture, and processing that are intended to make our food safer and healthier. Phytosanitary products, processing aids, food additives, and surfaces that touch food in storage can all transfer nanoparticles that might be consumed by humans. In a review published in Frontiers in Allergy today, Mohammad Issa, at the Université Paris-Saclay, and colleagues pointed out that such a significant change to food production could have unforeseen health consequences. The team presented evidence that suggested that nanoparticles not only cross the placenta to reach developing fetuses but leave them at greater risk of potentially life-threatening food allergies. “Due to the immunotoxic and biocidal properties of nanoparticles, exposure may disrupt the host-intestinal microbiota’s beneficial exchanges and may interfere with intestinal barrier and gut-associated immune system development in fetus and neonate,” said Dr Karine Adel-Patient, corresponding author of the study. “This may be linked to the epidemic of immune-related disorders in children, such as […]