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REVIEW article

Front. Transplant.
Sec. Transplantation Immunology
Volume 4 - 2025 | doi: 10.3389/frtra.2025.1518772
This article is part of the Research Topic Innate Mechanisms Affecting Transplant Outcomes View all articles

IMMUNOMODULATION BY ALLOGRAFT ENDOTHELIAL CELLS

Provisionally accepted
Sayantan Bose Sayantan Bose 1Vicki Do Vicki Do 2Chiara Testini Chiara Testini 1Suchita Jadhav Suchita Jadhav 1Nicolas Sailliet Nicolas Sailliet 1Alvin Kho Alvin Kho 3,4Masaki Komatsu Masaki Komatsu 1Leo Boneschansker Leo Boneschansker 1Sek Won Kong Sek Won Kong 3,4Johannes Wedel Johannes Wedel 1,3David Briscoe David Briscoe 1*
  • 1 Transplant Research Program, Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States
  • 2 Other
  • 3 Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States
  • 4 Transplant Research Program, Division of Nephrology, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States

The final, formatted version of the article will be published soon.

    It is increasingly appreciated that the expression of immunoregulatory molecules within tumors have potential to shape a microenvironment that promotes local immunoevasion and immunoregulation. However, little is known about tissue-intrinsic immunomodulatory mechanisms following transplantation. It is evident through extensive single cell RNA sequencing data that there is a marked heterogeneity in the phenotype of intragraft microvascular endothelial cells within organs, and we propose that differences in their phenotype impact the alloantigenicity of the graft and its potential to promote immunoregulation following transplantation. We focus this review on the concept that graft-dependent immunoregulation may evolve post-transplantation, and that it is dependent on the phenotype of select subsets of intragraft endothelial cells. We also discuss evidence that long-term graft survival is critically dependent on adaptive interactions among immune cells and endothelial cells within the transplanted tissue microenvironment.

    Keywords: endothelial cell, allograft (ALLO), Immunoregulation, Transplantation, Graft Survival

    Received: 28 Oct 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Bose, Do, Testini, Jadhav, Sailliet, Kho, Komatsu, Boneschansker, Kong, Wedel and Briscoe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: David Briscoe, Transplant Research Program, Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, Massachusetts, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.