Perspective

Accepted on 22 Nov 2024

Considering future qualification for regulatory science in the early development of Microphysiological Systems: a case study of microthrombosis in a Vessel-on-Chip

in Regulatory Toxicology

Huub J Weener
Heleen H T Middelkamp
Andries D Van Der Meer

Frontiers in Toxicology

doi 10.3389/ftox.2024.1513002

Original Research

Published on 01 Nov 2024

Identifying non-essential uses to phase out substances of very high concern under REACH

in Regulatory Toxicology

Flora Borchert
Romain Figuière
Ian T. Cousins
Christina Rudén
Marlene Ågerstrand

Frontiers in Toxicology

doi 10.3389/ftox.2024.1488336

1,277 views

Original Research

Published on 03 Oct 2024

Fulfilling the criteria for CLP classification: the implications for substances under the EU chemicals legislation

in Regulatory Toxicology

Diana Kättström
Anna Beronius
Urban Boije af Gennäs
Christina Rudén
Marlene Ågerstrand

Frontiers in Toxicology

doi 10.3389/ftox.2024.1452065

836 views

Brief Research Report

Published on 02 Oct 2024

Neonicotinoid pesticides: evidence of developmental neurotoxicity from regulatory rodent studies

in Regulatory Toxicology

Jennifer Beth Sass
Nathan Donley
William Freese

Frontiers in Toxicology

doi 10.3389/ftox.2024.1438890

3,279 views

Perspective

Published on 24 Sep 2024

Potential mammary carcinogens used in food contact articles: implications for policy, enforcement, and prevention

in Regulatory Toxicology

Lindsey V. Parkinson
Birgit Geueke
Jane Muncke

Frontiers in Toxicology

doi 10.3389/ftox.2024.1440331

11,363 views

Review

Published on 18 Sep 2024

Overview of human health effects related to glyphosate exposure

in Regulatory Toxicology

Flavia Silvia Galli
Marta Mollari
Valentina Tassinari
Cristian Alimonti
Alessandro Ubaldi
Camilla Cuva
Daniele Marcoccia

Frontiers in Toxicology

doi 10.3389/ftox.2024.1474792

2,369 views

Data Report

Published on 17 Sep 2024

A new database contains 520 studies investigating the carcinogenicity data of 238 pharmaceuticals across 14 ATC classifications

in Regulatory Toxicology

Panagiotis G. Karamertzanis
Martina Evangelisti
Marco Daniele Parenti
Jochen vom Brocke
Alberto Del Rio
Ingo Bichlmaier

Frontiers in Toxicology

doi 10.3389/ftox.2024.1450612

748 views

Original Research

Published on 16 Sep 2024

The use of in vitro bioassays and chemical screening to assess the impact of a minimally processed vegetable facility on wastewater quality

in Regulatory Toxicology

N. H. Aneck-Hahn
M. C. Van Zijl
L. Quinn
C. Swiegelaar
N. Nhlapo
W. de Bruin
L. Korsten

Frontiers in Toxicology

doi 10.3389/ftox.2024.1439126

561 views

Original Research

Published on 13 Sep 2024

Glyphosate and a glyphosate-based herbicide dysregulate the epigenetic landscape of Homeobox A10 (Hoxa10) gene during the endometrial receptivity in Wistar rats

in Regulatory Toxicology

Virginia Lorenz
Florencia Doná
Dalma B. Cadaviz
María M. Milesi
Jorgelina Varayoud

Frontiers in Toxicology

doi 10.3389/ftox.2024.1438826

707 views

Opinion

Published on 13 Aug 2024

Science evolves but outdated testing and static risk management in the US delay protection to human health

in Regulatory Toxicology

Maricel V. Maffini
Laura N. Vandenberg

Frontiers in Toxicology

doi 10.3389/ftox.2024.1444024

1,179 views

Original Research

Published on 24 Jul 2024

Characterization of a human thyroid microtissue model for testing thyroid disrupting chemicals

in Regulatory Toxicology

E. Rogers
E. K. Breathwaite
T. Nguyen-Jones
S. M. Anderson
J. J. Odanga
D. T. Parks
K. K. Wolf
T. Stone
P. Balbuena
J. Chen

Frontiers in Toxicology

doi 10.3389/ftox.2024.1408808

930 views

Policy and Practice Reviews

Published on 12 Jun 2024

Assessing human carcinogenicity risk of agrochemicals without the rodent cancer bioassay

in Regulatory Toxicology

Amber Goetz
Natalia Ryan
Alaina Sauve-Ciencewicki
Caleb C. Lord
Gina M. Hilton
Douglas C. Wolf

Frontiers in Toxicology

doi 10.3389/ftox.2024.1394361

1,609 views

Perspective

Published on 23 May 2024

ICH S1 prospective evaluation study and weight of evidence assessments: commentary from industry representatives

in Regulatory Toxicology

John L. Vahle
Joe Dybowski
Michael Graziano
Shigeru Hisada
Jose Lebron
Thomas Nolte
Ronald Steigerwalt
Kenjiro Tsubota
Frank D. Sistare

Frontiers in Toxicology

doi 10.3389/ftox.2024.1377990

1,686 views
1 citation

Original Research

Published on 11 Apr 2024

ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup

in Regulatory Toxicology

Todd Bourcier
Timothy McGovern
Tania Cavaliero
Geoffrey Ebere
Akiyoshi Nishikawa
Jihei Nishimura
Kumiko Ogawa
Markku Pasanen
Alisa Vespa
Jan Willem Van der Laan

Frontiers in Toxicology

doi 10.3389/ftox.2024.1353783

3,685 views
4 citations

Policy and Practice Reviews

Published on 05 Apr 2024

Developing a pragmatic consensus procedure supporting the ICH S1B(R1) weight of evidence carcinogenicity assessment

in Regulatory Toxicology

Arianna Bassan
Ronald Steigerwalt
Douglas Keller
Lisa Beilke
Paul M. Bradley
Frank Bringezu
William J. Brock
Leigh Ann Burns-Naas
Jon Chambers
Kevin Cross

Frontiers in Toxicology

doi 10.3389/ftox.2024.1370045

2,394 views
1 citation

Original Research

Published on 26 Mar 2024

Building an adverse outcome pathway network for estrogen-, androgen- and steroidogenesis-mediated reproductive toxicity

in Regulatory Toxicology

Johanna Zilliacus
Monica K. Draskau
Hanna K. L. Johansson
Terje Svingen
Anna Beronius

Frontiers in Toxicology

doi 10.3389/ftox.2024.1357717

1,534 views
4 citations

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Articles

Considering future qualification for regulatory science in the early development of Microphysiological Systems: a case study of microthrombosis in a Vessel-on-Chip

Identifying non-essential uses to phase out substances of very high concern under REACH

Fulfilling the criteria for CLP classification: the implications for substances under the EU chemicals legislation

Neonicotinoid pesticides: evidence of developmental neurotoxicity from regulatory rodent studies

Potential mammary carcinogens used in food contact articles: implications for policy, enforcement, and prevention

Overview of human health effects related to glyphosate exposure

A new database contains 520 studies investigating the carcinogenicity data of 238 pharmaceuticals across 14 ATC classifications

The use of in vitro bioassays and chemical screening to assess the impact of a minimally processed vegetable facility on wastewater quality

Glyphosate and a glyphosate-based herbicide dysregulate the epigenetic landscape of Homeobox A10 (Hoxa10) gene during the endometrial receptivity in Wistar rats

Science evolves but outdated testing and static risk management in the US delay protection to human health

Characterization of a human thyroid microtissue model for testing thyroid disrupting chemicals

Assessing human carcinogenicity risk of agrochemicals without the rodent cancer bioassay

ICH S1 prospective evaluation study and weight of evidence assessments: commentary from industry representatives

ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup

Developing a pragmatic consensus procedure supporting the ICH S1B(R1) weight of evidence carcinogenicity assessment

Building an adverse outcome pathway network for estrogen-, androgen- and steroidogenesis-mediated reproductive toxicity