Frontiers in Toxicology | In Vitro Toxicology

Original Research

Published on 12 Feb 2025

Development and characterization of a double-crested cormorant hepatic cell line, DCH22, for chemical screening

in In Vitro Toxicology

Tasnia Sharin
Doug Crump
Jason M. O’Brien

Frontiers in Toxicology

doi 10.3389/ftox.2025.1482865

161 views

Editorial

Published on 12 Feb 2025

Editorial: Leveraging artificial intelligence and open science for toxicological risk assessment

in In Vitro Toxicology

Marc Teunis
Thomas Luechtefeld
Thomas Hartung

Frontiers in Toxicology

doi 10.3389/ftox.2025.1568453

343 views

Original Research

Accepted on 04 Feb 2025

Evaluation of Estrogenic and Anti-Estrogenic Activity of Endocrine Disruptors using Breast Cancer Spheroids: A Comparative Study of T47D and MCF7 Cell Lines in 2D and 3D Models

in In Vitro Toxicology

Katia Barbaro
Elisa Innocenzi
Valentina Monteleone
Daniele Marcoccia
Annalisa Altigeri
Alessia Zepparoni
Daniela Caciolo
Cristian Alimonti
Marta Mollari
Paola Ghisellini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1547640

Original Research

Accepted on 13 Jan 2025

Evaluation of a non-animal toolbox informed by adverse outcome pathways (AOPs) for human inhalation safety

in In Vitro Toxicology

Maria Teresa Baltazar
Renato Ivan De Ávila
Iris Mueller
Hugh Barlow
Alistair Mark Middleton
Mathura Theiventhran
Danilo Basili
Anthony M Bowden
Ouarda Saib
Patrik Engi

Frontiers in Toxicology

doi 10.3389/ftox.2025.1426132

418 views

Original Research

Published on 28 Nov 2024

In vitro toxicological evaluation of pouched portioned oral nicotine products

in In Vitro Toxicology

Brian M. Keyser
Robert Leverette
Reagan McRae
John Wertman
Tom Shutsky
Ken Szeliga
Patrudu Makena
Kristen G. Jordan

Frontiers in Toxicology

doi 10.3389/ftox.2024.1452274

1,010 views

Review

Published on 26 Nov 2024

AI and ML-based risk assessment of chemicals: predicting carcinogenic risk from chemical-induced genomic instability

in In Vitro Toxicology

Ajay Vikram Singh
Preeti Bhardwaj
Peter Laux
Prachi Pradeep
Madleen Busse
Andreas Luch
Akihiko Hirose
Christopher J. Osgood
Michael W. Stacey

Frontiers in Toxicology

doi 10.3389/ftox.2024.1461587

2,059 views

Original Research

Published on 22 Nov 2024

Increasing sustainability and reproducibility of in vitro toxicology applications: serum-free cultivation of HepG2 cells

in In Vitro Toxicology

Luisa Marie Pfeifer
Janike Sensbach
Frederic Pipp
Daniela Werkmann
Philip Hewitt

Frontiers in Toxicology

doi 10.3389/ftox.2024.1439031

1,225 views

Original Research

Published on 06 Nov 2024

A multimodal in vitro approach to assess the safety of oral care products using 2D and 3D cellular models

in In Vitro Toxicology

S. Marceli Leano
Wanderson De Souza
Rodrigo De Vecchi
Amanda Lopes
Tatiana Deliberador
Jose M. Granjeiro

Frontiers in Toxicology

doi 10.3389/ftox.2024.1474583

1,080 views

Original Research

Published on 05 Nov 2024

Use of serum-free media for peripheral blood mononuclear cell culture and the impact on T and B cell readouts

in In Vitro Toxicology

Stella Cochrane
Ouarda Saib
David Sheffield

Frontiers in Toxicology

doi 10.3389/ftox.2024.1462688

1,628 views

Original Research

Published on 24 Oct 2024

Assessment of pulmonary fibrosis using weighted gene co-expression network analysis

in In Vitro Toxicology

Christina Drake
Walter Zobl
Sylvia E. Escher

Frontiers in Toxicology

doi 10.3389/ftox.2024.1465704

614 views

Review

Published on 08 Oct 2024

New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: workshop report

in In Vitro Toxicology

Lynne T. Haber
Mark A. Bradley
Amanda N. Buerger
Holger Behrsing
Sabina Burla
Phillip W. Clapp
Scott Dotson
Casey Fisher
Keith R. Genco
Francis H. Kruszewski

Frontiers in Toxicology

doi 10.3389/ftox.2024.1431790

3,012 views

Original Research

Published on 05 Sep 2024

Inhibitory effects of NaF on mitochondrial energy generation in human platelets in vitro

in In Vitro Toxicology

Tetsuhiro Tsujino
Tomoni Kasahara
Hideo Kawabata
Taisuke Watanabe
Koji Nishiyama
Yutaka Kitamura
Takao Watanabe
Hajime Okudera
Tomoharu Mochizuki
Takashi Ushiki

Frontiers in Toxicology

doi 10.3389/ftox.2024.1421184

1,278 views

Original Research

Published on 25 Jul 2024

Diesel exhaust particles alter mitochondrial bioenergetics and cAMP producing capacity in human bronchial epithelial cells

in In Vitro Toxicology

Isabella Cattani-Cavalieri
Marina Trombetta-Lima
Hong Yan
Ana L. Manzano-Covarrubias
Hoeke A. Baarsma
Asmaa Oun
Melissa Mol van der Veen
Emily Oosterhout
Amalia M. Dolga
Rennolds S. Ostrom

Frontiers in Toxicology

doi 10.3389/ftox.2024.1412864

1,669 views
2 citations

Original Research

Published on 23 Jul 2024

An insight into carcinogenic activity and molecular mechanisms of Bis(2-ethylhexyl) phthalate

in In Vitro Toxicology

Gelsomina Pillo
Federico Aldrovandi
Ada Mescoli
Giangabriele Maffei
Maria Grazia Mascolo
Monica Vaccari
Annamaria Colacci

Frontiers in Toxicology

doi 10.3389/ftox.2024.1389160

2,459 views

Correction

Published on 19 Jul 2024

Corrigendum: Applying new approach methodologies to assess next-generation tobacco and nicotine products

in In Vitro Toxicology

David Thorne
Damian McHugh
Liam Simms
K. Monica Lee
Hitoshi Fujimoto
Sara Moses
Marianna Gaca

Frontiers in Toxicology

doi 10.3389/ftox.2024.1460271

607 views

Review

Published on 17 Jul 2024

Unleashing the potential of cell painting assays for compound activities and hazards prediction

in In Vitro Toxicology

Floriane Odje
David Meijer
Elena von Coburg
Justin J. J. van der Hooft
Sebastian Dunst
Marnix H. Medema
Andrea Volkamer

Frontiers in Toxicology

doi 10.3389/ftox.2024.1401036

3,414 views
1 citation

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Articles

Development and characterization of a double-crested cormorant hepatic cell line, DCH22, for chemical screening

Editorial: Leveraging artificial intelligence and open science for toxicological risk assessment

Evaluation of Estrogenic and Anti-Estrogenic Activity of Endocrine Disruptors using Breast Cancer Spheroids: A Comparative Study of T47D and MCF7 Cell Lines in 2D and 3D Models

Evaluation of a non-animal toolbox informed by adverse outcome pathways (AOPs) for human inhalation safety

In vitro toxicological evaluation of pouched portioned oral nicotine products

AI and ML-based risk assessment of chemicals: predicting carcinogenic risk from chemical-induced genomic instability

Increasing sustainability and reproducibility of in vitro toxicology applications: serum-free cultivation of HepG2 cells

A multimodal in vitro approach to assess the safety of oral care products using 2D and 3D cellular models

Use of serum-free media for peripheral blood mononuclear cell culture and the impact on T and B cell readouts

Assessment of pulmonary fibrosis using weighted gene co-expression network analysis

New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: workshop report

Inhibitory effects of NaF on mitochondrial energy generation in human platelets in vitro

Diesel exhaust particles alter mitochondrial bioenergetics and cAMP producing capacity in human bronchial epithelial cells

An insight into carcinogenic activity and molecular mechanisms of Bis(2-ethylhexyl) phthalate

Corrigendum: Applying new approach methodologies to assess next-generation tobacco and nicotine products

Unleashing the potential of cell painting assays for compound activities and hazards prediction