Original Research

Published on 17 Oct 2024

A new approach methodology to identify tumorigenic chemicals using short-term exposures and transcript profiling

in Computational Toxicology and Informatics

J. Chris Corton
Michael DeVito
Michael Hughes
Leah Wehmas
William Gwinn
Gregory Akerman
Logan J Everett
Scott Auerbach

Frontiers in Toxicology

doi 10.3389/ftox.2024.1422325

366 views

Original Research

Published on 01 Oct 2024

Workflow for predictive risk assessments of UVCBs: cheminformatics library design, QSAR, and read-across approaches applied to complex mixtures of metal naphthenates

in Computational Toxicology and Informatics

Patricia Ruiz
Andrew Prussia

Frontiers in Toxicology

doi 10.3389/ftox.2024.1452838

415 views

Technology and Code

Published on 22 Jul 2024

Transforming environmental health datasets from the comparative toxicogenomics database into chord diagrams to visualize molecular mechanisms

in Computational Toxicology and Informatics

Allan Peter Davis
Brent Wyatt

Frontiers in Toxicology

doi 10.3389/ftox.2024.1437884

967 views
1 citation

Methods

Published on 15 Jul 2024

sendigR: an R package to leverage the value of CDISC SEND datasets for cross-study analysis

in Computational Toxicology and Informatics

Wenxian Wang
BRIANNA PAISLEY
William Houser
Susan Butler
Md Yousuf Ali
C M Sabbir Ahmed
Kevin Snyder

Frontiers in Toxicology

doi 10.3389/ftox.2024.1392686

898 views
1 citation

Editorial

Published on 02 Jul 2024

Editorial: Next generation chemical risk assessment: integration of advances in toxicology, biology and computation

in Computational Toxicology and Informatics

BERNARD GADAGBUI
Chao Ji
Kan Shao

Frontiers in Toxicology

doi 10.3389/ftox.2024.1440229

541 views

Original Research

Published on 10 May 2024

The application of natural language processing for the extraction of mechanistic information in toxicology

in Computational Toxicology and Informatics

Marie Corradi
Thomas Luechtefeld
Alyanne M. de Haan
Raymond Pieters
Jonathan H. Freedman
Tamara Vanhaecke
Mathieu Vinken
Marc Teunis

Frontiers in Toxicology

doi 10.3389/ftox.2024.1393662

3,375 views

Original Research

Published on 17 Apr 2024

Chemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models

in Computational Toxicology and Informatics

Mark D. Nelms
Todor Antonijevic
Caroline Ring
Danni L. Harris
Ronnie Joe Bever
Scott G. Lynn
David Williams
Grace Chappell
Rebecca Boyles
Susan Borghoff

Frontiers in Toxicology

doi 10.3389/ftox.2024.1346767

830 views

Perspective

Published on 28 Mar 2024

Digitalization of toxicology: improving preclinical to clinical translation

in Computational Toxicology and Informatics

Brian R. Berridge
Szczepan W. Baran
Vivek Kumar
Natalie Bratcher-Petersen
Michael Ellis
Chang-Ning Liu
Timothy L. Robertson

Frontiers in Toxicology

doi 10.3389/ftox.2024.1377542

1,895 views
2 citations

Original Research

Published on 21 Mar 2024

A novel method to derive a human safety limit for PFOA by gene expression profiling and modelling

in Computational Toxicology and Informatics

Arthur de Carvalho e Silva
George D. Loizou
Kevin McNally
Olivia Osborne
Claire Potter
David Gott
John K. Colbourne
Mark R. Viant

Frontiers in Toxicology

doi 10.3389/ftox.2024.1368320

1,615 views
1 citation

Original Research

Published on 11 Mar 2024

Optimizing androgen receptor prioritization using high-throughput assay-based activity models

in Computational Toxicology and Informatics

Ronnie Joe Bever
Stephen W. Edwards
Todor Antonijevic
Mark D. Nelms
Caroline Ring
Danni Harris
Scott G. Lynn
David Williams
Grace Chappell
Rebecca Boyles

Frontiers in Toxicology

doi 10.3389/ftox.2024.1347364

950 views
1 citation

Mini Review

Published on 19 Jan 2024

Computational models for predicting liver toxicity in the deep learning era

in Computational Toxicology and Informatics

Fahad Mostafa
Minjun Chen

Frontiers in Toxicology

doi 10.3389/ftox.2023.1340860

2,873 views
2 citations

Original Research

Published on 17 Nov 2023

Mining toxicogenomic data for dose-responsive pathways: implications in advancing next-generation risk assessment

in Computational Toxicology and Informatics

A. Rasim Barutcu
Michael B. Black
Andy Nong

Frontiers in Toxicology

doi 10.3389/ftox.2023.1272364

1,739 views
2 citations

Original Research

Published on 21 Sep 2023

The ToxCast pipeline: updates to curve-fitting approaches and database structure

in Computational Toxicology and Informatics

M. Feshuk
L. Kolaczkowski
K. Dunham
S. E. Davidson-Fritz
K. E. Carstens
J. Brown
R. S. Judson
K. Paul Friedman

Frontiers in Toxicology

doi 10.3389/ftox.2023.1275980

4,571 views
9 citations

Mini Review

Published on 11 Sep 2023

ToxRefDB v2.1: update to curated in vivo study data in the Toxicity Reference Database

in Computational Toxicology and Informatics

Madison Feshuk
Lori Kolaczkowski
Sean Watford
Katie Paul Friedman

Frontiers in Toxicology

doi 10.3389/ftox.2023.1260305

2,024 views
6 citations

Correction

Published on 24 Aug 2023

Corrigendum: Tox21Enricher-Shiny: an R Shiny application for toxicity functional annotation analysis

in Computational Toxicology and Informatics

Parker Combs
Jeremy Erickson
Jui-Hua Hsieh
Kai Guo
Sue Nolte
Charles Schmitt
Scott Auerbach
Junguk Hur

Frontiers in Toxicology

doi 10.3389/ftox.2023.1278066

693 views

Technology and Code

Published on 27 Jun 2023

Tox21Enricher-Shiny: an R Shiny application for toxicity functional annotation analysis

in Computational Toxicology and Informatics

Parker Combs
Jeremy Erickson
Jui-Hua Hsieh
Kai Guo
Sue Nolte
Charles Schmitt
Scott Auerbach
Junguk Hur

Frontiers in Toxicology

doi 10.3389/ftox.2023.1147608

3,590 views

Navigation group

Articles

A new approach methodology to identify tumorigenic chemicals using short-term exposures and transcript profiling

Workflow for predictive risk assessments of UVCBs: cheminformatics library design, QSAR, and read-across approaches applied to complex mixtures of metal naphthenates

Transforming environmental health datasets from the comparative toxicogenomics database into chord diagrams to visualize molecular mechanisms

sendigR: an R package to leverage the value of CDISC SEND datasets for cross-study analysis

Editorial: Next generation chemical risk assessment: integration of advances in toxicology, biology and computation

The application of natural language processing for the extraction of mechanistic information in toxicology

Chemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models

Digitalization of toxicology: improving preclinical to clinical translation

A novel method to derive a human safety limit for PFOA by gene expression profiling and modelling

Optimizing androgen receptor prioritization using high-throughput assay-based activity models

Computational models for predicting liver toxicity in the deep learning era

Mining toxicogenomic data for dose-responsive pathways: implications in advancing next-generation risk assessment

The ToxCast pipeline: updates to curve-fitting approaches and database structure

ToxRefDB v2.1: update to curated in vivo study data in the Toxicity Reference Database

Corrigendum: Tox21Enricher-Shiny: an R Shiny application for toxicity functional annotation analysis

Tox21Enricher-Shiny: an R Shiny application for toxicity functional annotation analysis