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MINI REVIEW article

Front. Toxicol.
Sec. Food and Nutritional Toxicology
Volume 6 - 2024 | doi: 10.3389/ftox.2024.1463758

Ergot alkaloid control in biotechnological processes and pharmaceuticals (a mini review)

Provisionally accepted
Andrei Volnin Andrei Volnin *Andrei Parshikov Andrei Parshikov Natalia Tsybulko Natalia Tsybulko Prascovia Mizina Prascovia Mizina Nikolay Sidelnikov Nikolay Sidelnikov
  • All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Moscow, Russia

The final, formatted version of the article will be published soon.

    The control of ergot alkaloids in biotechnological processes is important in the context of obtaining new strain producers and studying the mechanisms of the biosynthesis, accumulation and secretion of alkaloids and the manufacturing of alkaloids. In pharmaceuticals, it is important to analyze the purity of raw materials, especially those capable of racemization, quality control of dosage forms and bulk drugs, stability during storage, etc. This review describes the methods used for qualitative and quantitative chemical analysis of ergot alkaloids in tablets and pharmaceutic forms, liquid cultural media and mycelia from submerged cultures of ergot and other organisms producing ergoalkaloid, sclerotias of industrial Claviceps spp. parasitic strains. We reviewed analytical approaches for the determination of ergopeptines (including their dihydro-and bromine derivatives) and semisynthetic ergot-derived medicines such as cabergoline, necergoline and pergolide, including precursors for their synthesis.

    Keywords: Ergot Alkaloids, Ergoalkaloids, qualitative analysis, quantitative analysis, express methods, high-precision methods, HPLC, Process Analytical Technology

    Received: 12 Jul 2024; Accepted: 27 Sep 2024.

    Copyright: © 2024 Volnin, Parshikov, Tsybulko, Mizina and Sidelnikov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Andrei Volnin, All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Moscow, Russia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.