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CASE REPORT article
Front. Surg.
Sec. Surgical Oncology
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1456485
This article is part of the Research Topic Frontier Developments in Immunotherapy for Hepatocellular Carcinoma View all articles
A Rare Small Bowel Sarcoma: case report
Provisionally accepted
Jiwu Guo *
Jie Mao - Lanzhou University Second Hospital, Lanzhou, China
Intestinal sarcomas are rare gastrointestinal tumors, while its etiology is not clear. A middle-age man was admitted to hospital on Apr. 11, 2023 because of intermittent melena for 1 month.Gastroscopy and colonoscopy did not reveal any clues, however, melena persisted. Abdominal magnetic resonance imaging (MRI) indicated a left mid-abdominal mass and lymphoma of the small bowel origin. Small bowel enteroscopy revealed infiltrating periannular ulcer lesions in the jejunum.He received operation, and a partial resection of the small intestine was performed. Pathological examination revealed a mesenchymal, highly malignant, poorly differentiated sarcoma. The patient died 6 months after surgery. 19 months before being diagnosed with intestinal sarcoma, the patient was diagnosed with hepatocellular cancer and received immune checkpoint inhibitors (PD-1, sintilimab) combined with bevacizumab for 14 cycles, and achieved complete remission. While immunotherapy has achieved good therapeutic effect, another problem that has to be paid attention was immune-related adverse reactions, which involve multiple systems. Based on the above information, we believe that this small bowel sarcoma was a rare complication of immunotherapy.
Keywords: Gansu Province College Innovation Fund Project (2021B-38); Cuiying Scientific and Small Bowel Sarcoma, hepatocellular cancer, immune checkpoint inhibitors, Immunerelated adverse reactions, case report
Received: 28 Jun 2024; Accepted: 17 Feb 2025.
Copyright: © 2025 Guo and Mao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiwu Guo, Lanzhou University Second Hospital, Lanzhou, China
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