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ORIGINAL RESEARCH article

Front. Psychol.
Sec. Psychology for Clinical Settings
Volume 15 - 2024 | doi: 10.3389/fpsyg.2024.1454947

Anxiety -depression： a pivotal mental factor for accelerating disease progression and reducing curative effect in vitiligo patients

Provisionally accepted
Cheng Cao Cheng Cao 1,2Fuquan Lin Fuquan Lin 1*Rong Jin Rong Jin 1*Jindi Lei Jindi Lei 1,2*Yujie Zheng Yujie Zheng 1,2*Anqi Sheng Anqi Sheng 1*Wen Xu Wen Xu 1*Aie Xu Aie Xu 1Miaoni Zhou Miaoni Zhou 1*
  • 1 Department of Dermatology, Third People’s Hospital of Hangzhou, Hangzhou, China
  • 2 School of Basic Medical Sciences and School of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Objective: To clarify the causal relationship between anxiety-depression and the progression and outcomes of vitiligo, providing a basis for enhancing psychological interventions in the treatment of vitiligo. Methods: A two-sample Mendelian randomization analysis was used to validate the causal relationship between anxiety, depression, and vitiligo. The Hospital Anxiety and Depression Scale (HADS) assessed the psychiatric condition of vitiligo patients. Fisher's chi-square tests and rank sum tests analyzed the differences in clinical characteristics among vitiligo patients with different HADS scores. Regression analysis assessed the correlation between anxiety-depression and disease progression and treatment outcomes. Results: Mendelian randomization analysis showed that depression significantly increases the risk of vitiligo (OR=4.46, 95% CI: 1.16-17.18, P=0.03). According to the HADS scores, clinical characteristics differed significantly among the groups (P<0.05). Univariate regression analysis demonstrated that both HADS (B=-1.168, P<0.001, 95% CI: -1.532 to -0.804) and VIDA (B=-2.157, P<0.001, 95% CI: -3.464 to -0.887) were significantly negative associated factors for disease outcomes. However, HADS (B=-1.006, P<0.001, 95% CI: -1.475 to -0.657) emerged as the only factor influencing therapeutic efficacy in multivariate regression analysis. A restricted cubic spline graph illustrates a U-shaped relationship between HADS and clinical efficacy, with the most significant impact on therapeutic efficacy occurring when HADS equals 15. Conclusion: Anxiety - depression exhibit a bidirectional positive causal relationship with vitiligo. Moderate to severe anxiety-depression significantly influences the clinical efficacy of vitiligo treatment.

    Keywords: Vitiligo, Observational study, Anxiety, Depression, Mendelian randomization

    Received: 26 Jun 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Cao, Lin, Jin, Lei, Zheng, Sheng, Xu, Xu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Fuquan Lin, Department of Dermatology, Third People’s Hospital of Hangzhou, Hangzhou, China
    Rong Jin, Department of Dermatology, Third People’s Hospital of Hangzhou, Hangzhou, China
    Jindi Lei, Department of Dermatology, Third People’s Hospital of Hangzhou, Hangzhou, China
    Yujie Zheng, Department of Dermatology, Third People’s Hospital of Hangzhou, Hangzhou, China
    Anqi Sheng, Department of Dermatology, Third People’s Hospital of Hangzhou, Hangzhou, China
    Wen Xu, Department of Dermatology, Third People’s Hospital of Hangzhou, Hangzhou, China
    Miaoni Zhou, Department of Dermatology, Third People’s Hospital of Hangzhou, Hangzhou, China

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