Skip to main content

ORIGINAL RESEARCH article

Front. Psychol.
Sec. Neuropsychology
Volume 15 - 2024 | doi: 10.3389/fpsyg.2024.1417947
This article is part of the Research Topic Current Status of Neural Networks that Subserve Emotion and Cognition - Unraveling the Complex Brain through Multidisciplinary Contributions in Awake Brain Surgery View all articles

Filling the Gap: brief neuropsychological assessment protocol for glioma patients undergoing awake surgeries

Provisionally accepted
Juliana B. Ohy Juliana B. Ohy 1Cleiton Formentin Cleiton Formentin 1,2Daniel A. Gripp Daniel A. Gripp 1Joab N. Junior Joab N. Junior 1MAIRA C. VELHO MAIRA C. VELHO 1Larissa N. Vilany Larissa N. Vilany 1Gabriel F. Greggianin Gabriel F. Greggianin 1Beatriz Sartori Beatriz Sartori 1Ana Carolina Pinheiro Campos Ana Carolina Pinheiro Campos 1Silvia Mazzali Verst Silvia Mazzali Verst 1Marcos Vinicius C. Maldaun Marcos Vinicius C. Maldaun 1*
  • 1 Department of Neuro-Oncology, Hospital Sirio Libanes, SAO PAULO, Brazil
  • 2 State University of Campinas, Campinas, Brazil

The final, formatted version of the article will be published soon.

    Introduction: The literature lacks a concise neurocognitive test for assessing primary cognitive domains in neuro-oncological patients. This study aims to describe and assess the feasibility of the Ohy-Maldaun Fast Track Cognitive Test (OMFTCT), used to pre-and post-operatively evaluate patients undergoing brain tumor surgery in language eloquent areas. The cognitive diagnosis was used to safely guide intraoperative language assessment. Methods: This is a prospective longitudinal observational clinical study conducted on a cohort of 50 glioma patients eligible for awake craniotomies. The proposed protocol assesses multiple cognitive domains, including language, short-term verbal and visual memories, working memory, praxis, executive functions, and calculation ability. The protocol comprises ten different subtests, with a maximum score of 50 points, and was applied at three time points: preoperative, immediately postoperative period, and 30 days after surgery.Results: Among the initial 50 patients enrolled, 36 underwent assessment at all three designated time points.The mean age of the patients was 45.3 years, and they presented an average of 15 years of education. The predominant tumor types included Glioblastoma, IDH-wt (44.1%), and diffuse astrocytoma, IDH-mutant (41.2%). The tumors were located in the left temporal lobe (27.8%), followed by the left frontal lobe (25%).The full test had an average application time of 23 minutes.Conclusion: OMFTCT provided pre-and postoperative assessments of different cognitive domains, enabling more accurate planning of intraoperative language testing. Additionally, recognition of postoperative cognitive impairments played a crucial role in optimizing patient care.

    Keywords: neuropsychological assessment, Awake craniotomy, Glioma, Language mapping, Maximal safe resection

    Received: 15 Apr 2024; Accepted: 19 Jul 2024.

    Copyright: © 2024 Ohy, Formentin, Gripp, Junior, VELHO, Vilany, Greggianin, Sartori, Pinheiro Campos, Verst and Maldaun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Marcos Vinicius C. Maldaun, Department of Neuro-Oncology, Hospital Sirio Libanes, SAO PAULO, Brazil

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.