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REVIEW article

Front. Psychiatry
Sec. Psychopathology
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1505991
This article is part of the Research Topic Psychological Factors as Determinants of Medical Conditions, Volume III View all articles

Estradiol Metabolism by Gut Microbiota in Women's Depression Pathogenesis: Inspiration from Nature

Provisionally accepted
Wei Zhang Wei Zhang 1*Hanhan Jia Hanhan Jia 1Yuhang Yang Yuhang Yang 1*Dawei Ye Dawei Ye 2*Yan Li Yan Li 3*Jinxi Wang Jinxi Wang 1*Di Li Di Li 2*
  • 1 Department of General Surgery, Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China
  • 2 Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
  • 3 Department of Neurology, Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China

The final, formatted version of the article will be published soon.

    The recurrence and treatment resistance of depression remain significant issues, primarily due to an inadequate understanding of its pathogenesis. Recent scientific evidence indicates that gut microbiota influence estradiol metabolism and are associated with the development of depression in nonpremenopausal women.Integrating existing studies on the regulation of estradiol metabolism by microorganisms in nature and the relevance of its degradation products to depression, recent scientific explorations have further elucidated the key mechanisms by which gut microbiota catabolize estradiol through specific metabolic pathways. These emerging scientific findings suggest that the unique metabolic effects of gut microbiota on estradiol may be one of the central drivers in the onset and course of depression in non-menopausal women.

    Keywords: Gut Microbiota, Women, Estradiol, Depression, Degradation products, nature

    Received: 04 Oct 2024; Accepted: 10 Jan 2025.

    Copyright: © 2025 Zhang, Jia, Yang, Ye, Li, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wei Zhang, Department of General Surgery, Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China
    Yuhang Yang, Department of General Surgery, Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China
    Dawei Ye, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China
    Yan Li, Department of Neurology, Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China
    Jinxi Wang, Department of General Surgery, Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China
    Di Li, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.