Skip to main content

ORIGINAL RESEARCH article

Front. Psychiatry
Sec. Molecular Psychiatry
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1431942
This article is part of the Research Topic Underpinnings of Neuropsychiatric and Neurodevelopmental Disorders: From Molecules to Behaviour View all articles

Predicting Psychiatric Risk: IgG N-Glycosylation Traits as Biomarkers for Mental Health

Provisionally accepted
Yinchun Lv Yinchun Lv 1*Yulin Chen Yulin Chen 1Xue Li Xue Li 1Qiaorong Hang Qiaorong Hang 1Ran Lu Ran Lu 2Junman Ye Junman Ye 1Wentong Meng Wentong Meng 1Chuanwen Fan Chuanwen Fan 2Xianming Mo Xianming Mo 1
  • 1 West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 2 West China Fourth Hospital of Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Background: Growing evidence suggests that chronic inflammation, resulting from intricate immune system interactions, significantly contributes to the onset of psychiatric disorders. Observational studies have identified a link between immunoglobulin G (IgG) N-glycosylation and various psychiatric conditions, but the causality of these associations remains unclear. Methods: Genetic variants for IgG N-glycosylation traits and psychiatric disorders were obtained from published genome-wide association studies. The inverse-variance-weighted (IVW) method, MR-Egger, and weighted median were used to estimate causal effects. The Cochran's Q test, MR-Egger intercept test, leave-one-out analyses, and MR-PRESSO global test were used for sensitivity analyses. Results: In the Psychiatric Genomics Consortium (PGC) database, genetically predicted IGP7 showed a protective role in schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP), while elevated IGP34, and IGP57 increased SCZ risk. High levels of IGP21 were associated with an increased risk of post-traumatic stress disorder (PTSD), while elevated levels of IGP22 exhibited a causal association with a decreased risk of attention-deficit/hyperactivity disorder (ADHD). No causal relationship between IgG N-glycan traits and autism spectrum disorder (ASD) and no evidence of reverse causal associations was found. Conclusion: Here, we demonstrate that IgG N-glycan traits have a causal relationship with psychiatric disorders, especially IGP7’s protective role, offering new insights into their pathogenesis. Our findings suggest potential strategies for predicting and intervening in psychiatric disorder risk through IgG N-glycan traits.

    Keywords: IgG, N-glycosylation, psychiatric disorders, Mendelian randomization, Mental Health

    Received: 13 May 2024; Accepted: 31 Oct 2024.

    Copyright: © 2024 Lv, Chen, Li, Hang, Lu, Ye, Meng, Fan and Mo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yinchun Lv, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.