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ORIGINAL RESEARCH article

Front. Physiol.
Sec. Autonomic Neuroscience
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1511998
This article is part of the Research Topic Cardio-Respiratory-Brain Integrative Physiology: Interactions, Mechanisms, and Methods for Assessment View all 7 articles

Detection of respiratory frequency rhythm in human alpha phase shifts: topographic distributions in wake and drowsy states

Provisionally accepted
Aleksandar Kalauzi Aleksandar Kalauzi 1Zoran Andrija Matić Zoran Andrija Matić 2Edin Suljovrujić Edin Suljovrujić 2Tijana Bojić Tijana Bojić 2*
  • 1 Institute for Multidisciplinary Research, University of Belgrade, Belgrade, Serbia
  • 2 Vinča Institute of Nuclear Science, University of Belgrade, Belgrade, Serbia

The final, formatted version of the article will be published soon.

    Although studied for a long time, relationship between brain activity and respiration is recently attracting increasing attention. Respiratory modulation was evidenced both on single cell activity and field potentials. Among EEG and intracranial measurements, effect of respiration was prevailingly studied on amplitude/power in all frequency bands. Since phases of EEG oscillations received less attention, we applied our previously published carrier frequency (CF) mathematical model of human alpha oscillations on a group of ten young healthy participants in wake and drowsy states, using a 14 channel average reference montage. Since our approach allows for a more precise calculation of CF phase shifts (CFPS) than any separate Fourier components, by using a 2 s moving Fourier window, we validated the new method and studied, for the first time, temporal waveforms CFPS(t) as well as their oscillatory content through FFT(CFPS(t)). Although not appearing equally in all channel pairs and every subject, a clear peak in the respirarory frequency region, 0.21 -0.26 Hz was observed (max at 0.22 Hz). When five channel pairs with the most prominent group averaged amplitudes at 0.22 Hz were plotted in both states, topographic distributions changed significantlyfrom longitudinal, connecting frontal and posterior channels in wake, into topograpnhically splitted two separate regions-frontal and posterior in drowsy. In addition, in drowsy, 0.22 Hz amplitudes decreased for all pairs, while statistically significant reduction was obtained for 20/91 (22%) pairs. These results potentially evidence for the first time respiratory frequency modulation of alpha phase shifts and point to great impact of wakeful consciousness on the observed oscillations.

    Keywords: Respiration, EEG, alpha activity, phase shift, Wake and drowsy, mind-body interaction

    Received: 18 Oct 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 Kalauzi, Matić, Suljovrujić and Bojić. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Tijana Bojić, Vinča Institute of Nuclear Science, University of Belgrade, Belgrade, 11001, Serbia

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