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ORIGINAL RESEARCH article

Front. Physiol.
Sec. Lipid and Fatty Acid Research
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1457349

Lipid Metabolic Profiling and Diagnostic Model Development for Hyperlipidemic Acute Pancreatitis

Provisionally accepted
Dongmei Ren Dongmei Ren 1Yong Li Yong Li 1*Guangnian Zhang Guangnian Zhang 1*Tiantian Li Tiantian Li 1*Zhenglong Liu Zhenglong Liu 2*
  • 1 Affiliated Hospital of North Sichuan Medical College, Nanchong, China
  • 2 North Sichuan Medical College, Nanchong, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Hyperlipidemic acute pancreatitis (HLAP) is a form of pancreatitis caused by hyperlipidemia, which poses significant diagnostic challenges. This research examined the serum lipid metabolism profiles of HLAP patients compared to a healthy cohort. By employing ultra-performance liquid chromatography-tandem mass spectrometry and orthogonal partial least squares discriminant analysis (OPLS-DA), 393 distinct lipid metabolites were detected, affecting critical metabolic pathways such as fatty acid metabolism, sphingolipid metabolism, and glycerophospholipid metabolism. Using Logistic regression and LASSO regression methods, five specific lipid molecules were identified to create a diagnostic model, achieving an AUC of 1 in the ROC curve, indicating exceptional diagnostic accuracy. These results emphasize the importance of lipid metabolism disturbances in HLAP and suggest these lipid molecules could serve as valuable biomarkers for diagnosing HLAP.

    Keywords: Hyperlipidemic acute pancreatitis, lipidomics, Metabolic biomarkers, Diagnostic model, biomarkers

    Received: 30 Jun 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Ren, Li, Zhang, Li and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yong Li, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
    Guangnian Zhang, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
    Tiantian Li, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
    Zhenglong Liu, North Sichuan Medical College, Nanchong, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.