Original Research

Published on 25 Jul 2024

When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement

in Translational Pharmacology

Yasunori Aoki
Malcom Rowland
Yuichi Sugiyama

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1366160

1,052 views

Review

Published on 25 Jul 2024

Ligand-conjugated multiwalled carbon nanotubes for cancer targeted drug delivery

in Translational Pharmacology

Chanchal Kiran Thakur
Chandrabose Karthikeyan
Charles R. Ashby
Rabin Neupane
Vishal Singh
R. Jayachandra Babu
N. S. Hari Narayana Moorthy
Amit K. Tiwari

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1417399

1,592 views
1 citation

Review

Published on 25 Jul 2024

Bibliometric and visualized analysis of ultrasound combined with microbubble therapy technology from 2009 to 2023

in Translational Pharmacology

Bin Tu
Yan Li
Wen Wen
Jian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1418142

1,184 views

Original Research

Published on 22 Jul 2024

Pan-cancer analyses reveal the molecular and clinical characteristics of TET family members and suggests that TET3 maybe a potential therapeutic target

in Translational Pharmacology

Chunyan Zhang
Jie Zheng
Jin Liu
Yanxia Li
Guoqiang Xing
Shupeng Zhang
Hekai Chen
Jian Wang
Zhijiang Shao
Yongyuan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1418456

1,245 views

Review

Published on 18 Jul 2024

Bibliometric analysis of vitamin D and obesity research over the period 2000 to 2023

in Translational Pharmacology

Xudong Song
Senhua Qin
Shuxin Chen
Can Zhang
Lin Lin
Ziyi Song

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1445061

1,737 views

Original Research

Published on 18 Jul 2024

Identifying potential therapeutic targets in lung adenocarcinoma: a multi-omics approach integrating bulk and single-cell RNA sequencing with Mendelian randomization

in Translational Pharmacology

Youpeng Chen
Enzhong Li
Zhenglin Chang
Tingting Zhang
Zhenfeng Song
Haojie Wu
Zhangkai J. Cheng
Baoqing Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1433147

2,540 views

Editorial

Published on 16 Jul 2024

Editorial: Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development

in Translational Pharmacology

H. Markus Weiss
Yuichi Sugiyama
Esther van Duijn

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1455643

604 views

Clinical Trial

Published on 15 Jul 2024

A phase 1, randomized, double-blind, placebo-controlled, dose escalation study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of SHR-1905, a long-acting anti-thymic stromal lymphopoietin antibody, in healthy subjects

in Translational Pharmacology

Yue Fei
Na Li
Weilin Qian
Yang Fan
Yu Shen
Quanren Wang
Kristi McLendon
Kai Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1400696

2,818 views
1 citation

Original Research

Published on 10 Jul 2024

Repurposing the Open Global Health Library for the discovery of novel Mpro destabilizers with scope as broad-spectrum antivirals

in Translational Pharmacology

Francisco Castillo
David Ramírez
María C. Ramos
Blanca Martinez-Arribas
Elisabeth Domingo-Contreras
Thomas A. Mackenzie
Carlos Peña-Varas
Sven Lindemann
Fernando Montero
Fredderick Annang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1390705

817 views

Original Research

Published on 03 Jul 2024

Individualized, dynamic, and full-course vancomycin dosing prediction: a study on the customized dose model

in Translational Pharmacology

Xiangqing Song
Meizi Zeng
Tao Yang
Mi Han
Shipeng Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1414347

824 views

Opinion

Published on 02 Jul 2024

Life scientists improve QSP model quality and impact

in Translational Pharmacology

Katherine Kudrycki
Christina Friedrich
Mike Reed
Rebecca A. Baillie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1392747

790 views

Case Report

Published on 27 Jun 2024

Case report: dose-dependent interaction between dexamethasone and voriconazole in severely ill patients with non-Hodgkin’s lymphoma being treated for invasive pulmonary aspergillosis

in Translational Pharmacology

Jingjing Huang
Yang Chen
Ming Zhong
Ruoming Tan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1403966

962 views
1 citation

Case Report

Published on 19 Jun 2024

Case report and literature review: management of Paxlovid (nirmatrelvir/ritonavir)-induced acute tacrolimus toxicity in a patient with systemic lupus erythematosus

in Translational Pharmacology

Chenxiao Jiang
Xiaodi Yan
Peng Xia
Xuemei Luo
Haoyue Zheng
Hanwen Tong
Yun Liu
Huaijun Zhu
Peng Xu
Jun Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1364121

1,444 views

Clinical Trial

Published on 12 Jun 2024

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial

in Translational Pharmacology

Yu-zhou Gui
Wei Wang
Qing-qing Wu
Qi-chen Ding
Hong-jie Qian
Qiu-bei Lu
Ying-jun Zhang
Yu-lei Zhuang
Li Deng
Ying-lin Zuo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1359939

1,297 views

Opinion

Published on 10 Jun 2024

Translational pathology in drug discovery

in Translational Pharmacology

Snježana Čužić
Maja Antolić
Anja Ognjenović
Vuk Milutinović
Sonja Vidović Iviš
Ines Glojnarić
Martina Bosnar
Lidija Požgaj
Ema Prenc
Vesna Eraković Haber

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1409092

841 views

Original Research

Published on 03 Jun 2024

Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy

in Translational Pharmacology

Rajbharan Yadav
Suzanne Schubbert
Patrick G. Holder
Eugene Y. Chiang
Nargess Kiabi
Liz Bogaert
Irene Leung
Rumana Rashid
Kendra N. Avery
Christine Bonzon

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1380000

1,960 views

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Articles

When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement

Ligand-conjugated multiwalled carbon nanotubes for cancer targeted drug delivery

Bibliometric and visualized analysis of ultrasound combined with microbubble therapy technology from 2009 to 2023

Pan-cancer analyses reveal the molecular and clinical characteristics of TET family members and suggests that TET3 maybe a potential therapeutic target

Bibliometric analysis of vitamin D and obesity research over the period 2000 to 2023

Identifying potential therapeutic targets in lung adenocarcinoma: a multi-omics approach integrating bulk and single-cell RNA sequencing with Mendelian randomization

Editorial: Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development

A phase 1, randomized, double-blind, placebo-controlled, dose escalation study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of SHR-1905, a long-acting anti-thymic stromal lymphopoietin antibody, in healthy subjects

Repurposing the Open Global Health Library for the discovery of novel Mpro destabilizers with scope as broad-spectrum antivirals

Individualized, dynamic, and full-course vancomycin dosing prediction: a study on the customized dose model

Life scientists improve QSP model quality and impact

Case report: dose-dependent interaction between dexamethasone and voriconazole in severely ill patients with non-Hodgkin’s lymphoma being treated for invasive pulmonary aspergillosis

Case report and literature review: management of Paxlovid (nirmatrelvir/ritonavir)-induced acute tacrolimus toxicity in a patient with systemic lupus erythematosus

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial

Translational pathology in drug discovery

Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy