Original Research

Published on 25 Jul 2024

When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement

in Translational Pharmacology

Yasunori Aoki
Malcom Rowland
Yuichi Sugiyama

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1366160

268 views

Review

Published on 25 Jul 2024

Ligand-conjugated multiwalled carbon nanotubes for cancer targeted drug delivery

in Translational Pharmacology

Chanchal Kiran Thakur
Chandrabose Karthikeyan
Charles R. Ashby
Rabin Neupane
Vishal Singh
R. Jayachandra Babu
N. S. Hari Narayana Moorthy
Amit K. Tiwari

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1417399

147 views

Review

Published on 25 Jul 2024

Bibliometric and visualized analysis of ultrasound combined with microbubble therapy technology from 2009 to 2023

in Translational Pharmacology

Bin Tu
Yan Li
Wen Wen
Jian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1418142

101 views

Original Research

Accepted on 23 Jul 2024

The Integrated Analysis of Gut Microbiota and Metabolome Revealed Steroid Hormone Biosynthesis is a Critical Pathway in Liver Regeneration after 2/3 Partial Hepatectomy

in Translational Pharmacology

Runbin Sun
Fei Fei
Dandan Jin
Haoyi Yang
Zhi Xu
Bei Cao
Juan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1407401

Clinical Trial

Accepted on 22 Jul 2024

No QTc prolongation with CDK 4/6 inhibitor FCN-437c: Results of a Concentration-QTc analysis from a Dedicated Study in Adult Healthy Subjects

in Translational Pharmacology

Lin Zhao
Yi Sun
Xiaoran Yang
Ling Tian
Lize Li
Fangfang Wang
Xiaoye Niu
Lei Diao
Haiyan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1433663

Original Research

Published on 22 Jul 2024

Pan-cancer analyses reveal the molecular and clinical characteristics of TET family members and suggests that TET3 maybe a potential therapeutic target

in Translational Pharmacology

Chunyan Zhang
Jie Zheng
Jin Liu
Yanxia Li
Guoqiang Xing
Shupeng Zhang
Hekai Chen
Jian Wang
Zhijiang Shao
Yongyuan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1418456

192 views

Perspective

Accepted on 18 Jul 2024

Artificial intelligence integration in the drug lifecycle and in regulatory science: policy implications, challenges and opportunities

in Translational Pharmacology

Wahiba OUALIKENE-GONIN
Marie-Christine Jaulent
Jean-Pierre Thierry
Sofia Oliveira- Martins
Laetitia BELGODERE
Patrick Maison
Joel Ankri

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437167

Review

Published on 18 Jul 2024

Bibliometric analysis of vitamin D and obesity research over the period 2000 to 2023

in Translational Pharmacology

Xudong Song
Senhua Qin
Shuxin Chen
Can Zhang
Lin Lin
Ziyi Song

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1445061

295 views

Original Research

Published on 18 Jul 2024

Identifying potential therapeutic targets in lung adenocarcinoma: a multi-omics approach integrating bulk and single-cell RNA sequencing with Mendelian randomization

in Translational Pharmacology

Youpeng Chen
Enzhong Li
Zhenglin Chang
Tingting Zhang
Zhenfeng Song
Haojie Wu
Zhangkai J. Cheng
Baoqing Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1433147

478 views

Editorial

Published on 16 Jul 2024

Editorial: Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development

in Translational Pharmacology

H. Markus Weiss
Yuichi Sugiyama
Esther van Duijn

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1455643

175 views

Editorial

Accepted on 15 Jul 2024

Editorial: Pharmacoinformatics: New developments and challenges in drug design

in Translational Pharmacology

David Ramírez
Rafael Peláez
Carlos F. Lagos
José L Medina-Franco

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1462070

Clinical Trial

Published on 15 Jul 2024

A phase 1, randomized, double-blind, placebo-controlled, dose escalation study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of SHR-1905, a long-acting anti-thymic stromal lymphopoietin antibody, in healthy subjects

in Translational Pharmacology

Yue Fei
Na Li
Weilin Qian
Yang Fan
Yu Shen
Quanren Wang
Kristi McLendon
Kai Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1400696

343 views

Original Research

Accepted on 11 Jul 2024

Nanoparticles (NPs)-mediated lncMALAT1 silencing to reverse cisplatin resistance for effective hepatocellular carcinoma therapy

in Translational Pharmacology

Xiaoding Xu
Ting Wang
Qianyao Li
Rui Xu
Zixuan Zhao
Rong Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437071

Original Research

Published on 10 Jul 2024

Repurposing the Open Global Health Library for the discovery of novel Mpro destabilizers with scope as broad-spectrum antivirals

in Translational Pharmacology

Francisco Castillo
David Ramírez
María C. Ramos
Blanca Martinez-Arribas
Elisabeth Domingo-Contreras
Thomas A. Mackenzie
Carlos Peña-Varas
Sven Lindemann
Fernando Montero
Fredderick Annang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1390705

295 views

Original Research

Accepted on 08 Jul 2024

The 5HT4R Agonist velusetrag efficacy on neuropathic chronic intestinal pseudo-obstruction in a PrP-SCA7-92Q Transgenic Mice

in Translational Pharmacology

Loredana Vesci
Yongqiang Liu
Yunfei Wu
Dewan Ren
Yulong Tao
Fangyi Mai
Jingyi Zhu
Xiang Li
Emanuela Colla
Maria Grimaldi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1411642

Review

Accepted on 08 Jul 2024

Impact of p53-associated acute myeloid leukemia hallmarks on metabolism and the immune environment

in Translational Pharmacology

Monika Chomczyk
Luca Gazzola
Shubhankar Dash
Patryk Firmanty
Vakul Mohanty
Natalia Baran

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1409210

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Articles

When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement

Ligand-conjugated multiwalled carbon nanotubes for cancer targeted drug delivery

Bibliometric and visualized analysis of ultrasound combined with microbubble therapy technology from 2009 to 2023

The Integrated Analysis of Gut Microbiota and Metabolome Revealed Steroid Hormone Biosynthesis is a Critical Pathway in Liver Regeneration after 2/3 Partial Hepatectomy

No QTc prolongation with CDK 4/6 inhibitor FCN-437c: Results of a Concentration-QTc analysis from a Dedicated Study in Adult Healthy Subjects

Pan-cancer analyses reveal the molecular and clinical characteristics of TET family members and suggests that TET3 maybe a potential therapeutic target

Artificial intelligence integration in the drug lifecycle and in regulatory science: policy implications, challenges and opportunities

Bibliometric analysis of vitamin D and obesity research over the period 2000 to 2023

Identifying potential therapeutic targets in lung adenocarcinoma: a multi-omics approach integrating bulk and single-cell RNA sequencing with Mendelian randomization

Editorial: Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development

Editorial: Pharmacoinformatics: New developments and challenges in drug design

A phase 1, randomized, double-blind, placebo-controlled, dose escalation study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of SHR-1905, a long-acting anti-thymic stromal lymphopoietin antibody, in healthy subjects

Nanoparticles (NPs)-mediated lncMALAT1 silencing to reverse cisplatin resistance for effective hepatocellular carcinoma therapy

Repurposing the Open Global Health Library for the discovery of novel Mpro destabilizers with scope as broad-spectrum antivirals

The 5HT4R Agonist velusetrag efficacy on neuropathic chronic intestinal pseudo-obstruction in a PrP-SCA7-92Q Transgenic Mice

Impact of p53-associated acute myeloid leukemia hallmarks on metabolism and the immune environment