Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 23 Mar 2023

Multi-omics reveals hypertrophy of adipose tissue and lipid metabolism disorder via mitochondria in young mice under real-ambient exposure to air pollution

in Predictive Toxicology

Honglin Si
Tianlin Gao
Jing Yang
Jing Zhu
Ying Han
Chengwei Li
Jianxin Wang
Jianyu Li
Yanjie Zhao
Lei Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1122615

3,165 views
12 citations

Original Research

Published on 23 Mar 2023

Development, testing, parameterisation, and calibration of a human PBK model for the plasticiser, di (2-ethylhexyl) adipate (DEHA) using in silico, in vitro and human biomonitoring data

in Predictive Toxicology

Kevin McNally
Craig Sams
George Loizou

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1165770

1,796 views

Original Research

Published on 07 Mar 2023

Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation

in Predictive Toxicology

Engi Abdelhady Algharably
Emma Di Consiglio
Emanuela Testai
Francesca Pistollato
Anna Bal-Price
Abdulkarim Najjar
Reinhold Kreutz
Ursula Gundert-Remy

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1136174

3,233 views
6 citations

Original Research

Published on 02 Mar 2023

The role of chondrocyte-to-osteoblast trans-differentiation in fetal bone dysplasia of mice caused by prenatal exposure to dexamethasone

in Predictive Toxicology

Jiayong Zhu
Xiaoqi Zhao
Hui Wang
Hao Xiao
Liaobin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1120041

2,000 views
2 citations

Original Research

Published on 02 Mar 2023

Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides

in Predictive Toxicology

Frances Widjaja
Liang Zheng
Sebastiaan Wesseling
Ivonne M. C. M. Rietjens

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1125146

1,819 views
6 citations

Original Research

Published on 02 Mar 2023

Molecular determinants of acrylamide neurotoxicity through covalent docking

in Predictive Toxicology

Nicolas Pierre Friedrich Mueller
Paolo Carloni
Mercedes Alfonso-Prieto

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1125871

3,906 views
4 citations

Original Research

Published on 22 Feb 2023

PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol

in Predictive Toxicology

Rory P. Conolly
Harvey J. Clewell
Martha M. Moore
Jerry L. Campbell
Wanyun Cheng
R. Robinan Gentry

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1088011

1,965 views
2 citations

Original Research

Published on 20 Feb 2023

Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data

in Predictive Toxicology

Kevin McNally
Craig Sams
Alex Hogg
George Loizou

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1140852

3,482 views
2 citations

Original Research

Published on 10 Feb 2023

Biosafety, histological alterations and residue depletion of feed administered anti-parasitic drug emamectin benzoate in golden mahseer, Tor putitora (Hamilton, 1822) as a model candidate fish for sport fishery and conservation in temperate waters

in Predictive Toxicology

Sumanta Kumar Mallik
Shivam Singh
Neetu Shahi
Prasanna Kumar Patil
Krishna Kala
Richa Pathak
Abhay Kumar Giri
Partha Das
Ritesh Shantilal Tandel
Suresh Chandra

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1106124

3,214 views
4 citations

Original Research

Published on 08 Feb 2023

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

in Predictive Toxicology

Thi-Phuong Tao
Ilka Maschmeyer
Edward L. LeCluyse
Eda Rogers
Katrin Brandmair
Silke Gerlach
Julia Przibilla
Fredy Kern
Camille Genies
Carine Jacques

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1076254

4,271 views
8 citations

Editorial

Published on 06 Feb 2023

Editorial: Toxicity mechanism and clinical features of PD-1/PD-l1 inhibitors in treatment of cancer, volume II

in Predictive Toxicology

Chuqi Lei
Xiangyi Kong
Ryan J. Sullivan
Caisheng Wu
Dawei Wang
Lin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1136373

1,416 views

Original Research

Published on 02 Feb 2023

Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals

in Predictive Toxicology

Qurat Ul Ain
Uzma Saleem
Bashir Ahmad
Iqra Khalid

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1111915

3,194 views
2 citations

Original Research

Published on 02 Feb 2023

Refinement and calibration of a human PBPK model for the plasticiser, Di-(2-propylheptyl) phthalate (DPHP) using in silico, in vitro and human biomonitoring data

in Predictive Toxicology

Kevin McNally
George Loizou

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1111433

2,124 views
2 citations

Original Research

Published on 26 Jan 2023

Fenchone, a monoterpene: Toxicity and diuretic profiling in rats

in Predictive Toxicology

Asifa Bashir
Muhammad Naveed Mushtaq
Waqas Younis
Irfan Anjum

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1119360

3,656 views
4 citations

Case Report

Published on 26 Jan 2023

Case report: An autopsy case of pilsicainide poisoning

in Predictive Toxicology

Sella Takei
Hiroshi Kinoshita
Mitsuru Kumihashi
Mostofa Jamal
Hiroko Abe
Shoji Kimura

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1090265

4,076 views
1 citation

Original Research

Published on 23 Jan 2023

Pharmacokinetics and biosafety evaluation of a veterinary drug florfenicol in rainbow trout, Oncorhynchus mykiss (Walbaum 1792) as a model cultivable fish species in temperate water

in Predictive Toxicology

Sumanta Kumar Mallik
Neetu Shahi
Richa Pathak
Krishna Kala
Prasanna Kumar Patil
Bhupendra Singh
Rajisha Ravindran
Nanitha Krishna
Pramod Kumar Pandey

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1033170

3,645 views
15 citations

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Articles

Multi-omics reveals hypertrophy of adipose tissue and lipid metabolism disorder via mitochondria in young mice under real-ambient exposure to air pollution

Development, testing, parameterisation, and calibration of a human PBK model for the plasticiser, di (2-ethylhexyl) adipate (DEHA) using in silico, in vitro and human biomonitoring data

Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation

The role of chondrocyte-to-osteoblast trans-differentiation in fetal bone dysplasia of mice caused by prenatal exposure to dexamethasone

Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides

Molecular determinants of acrylamide neurotoxicity through covalent docking

PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol

Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data

Biosafety, histological alterations and residue depletion of feed administered anti-parasitic drug emamectin benzoate in golden mahseer, Tor putitora (Hamilton, 1822) as a model candidate fish for sport fishery and conservation in temperate waters

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

Editorial: Toxicity mechanism and clinical features of PD-1/PD-l1 inhibitors in treatment of cancer, volume II

Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals

Refinement and calibration of a human PBPK model for the plasticiser, Di-(2-propylheptyl) phthalate (DPHP) using in silico, in vitro and human biomonitoring data

Fenchone, a monoterpene: Toxicity and diuretic profiling in rats

Case report: An autopsy case of pilsicainide poisoning

Pharmacokinetics and biosafety evaluation of a veterinary drug florfenicol in rainbow trout, Oncorhynchus mykiss (Walbaum 1792) as a model cultivable fish species in temperate water