Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 19 Jun 2024

Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells

in Predictive Toxicology

Minmin Qu
Jia Chen
Bin Xu
Qinyun Shi
Shujing Zhao
Zhaoxia Wang
Zhi Li
Bo Ma
Hua Xu
Qinong Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1356753

1,236 views

Original Research

Published on 19 Jun 2024

Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion

in Predictive Toxicology

Abdulkarim Najjar
Jochen Kühnl
Daniela Lange
Camille Géniès
Carine Jacques
Eric Fabian
Anne Zifle
Nicola J. Hewitt
Andreas Schepky

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1421601

2,686 views
3 citations

Review

Published on 18 Jun 2024

A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy

in Predictive Toxicology

Carlo Maria Bellanca
Egle Augello
Giulia Di Benedetto
Chiara Burgaletto
Anna Flavia Cantone
Giuseppina Cantarella
Renato Bernardini
Riccardo Polosa
the DiaSmokeFree Working Group
Agostino Di Ciaula

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1406860

3,970 views

Original Research

Published on 13 Jun 2024

Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling

in Predictive Toxicology

Xiaohuang Lin
Jian Zhang
Zekai Wu
Yuan Shi
Mengting Chen
Maodong Li
Hong Hu
Kun Tian
Xiaoqi Lv
Chutao Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1393717

1,723 views
3 citations

Original Research

Published on 17 May 2024

Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis

in Predictive Toxicology

Lihua Chen
Shaojian Chen
Yachen Li
Yi Qiu
Xiaojing Chen
Yuze Wu
Xian Deng
Mingliang Chen
Chunxiao Wang
Zhongshi Hong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1337883

1,553 views

Original Research

Published on 09 May 2024

Delineation of renal protein profiles in aristolochic acid I-induced nephrotoxicity in mice by label-free quantitative proteomics

in Predictive Toxicology

Xinhui Liu
Shanshan Wu
Yu Peng
Liwen Gao
Xi Huang
Ruyu Deng
Jiandong Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1341854

1,444 views

Original Research

Published on 10 Apr 2024

Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy

in Predictive Toxicology

James A. Coleman
Ruben Doste
Matteo Beltrami
Alessia Argirò
Raffaele Coppini
Iacopo Olivotto
Betty Raman
Alfonso Bueno-Orovio

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1379236

1,675 views
1 citation

Original Research

Published on 10 Apr 2024

Exploiting the predictive power of educated spheroids to detect immune-mediated idiosyncratic drug-induced liver injury: the case of troglitazone

in Predictive Toxicology

Salomé Roux
Sara Cherradi
Hong Tuan Duong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1378371

2,044 views
2 citations

Case Report

Published on 27 Mar 2024

Case report: Paralytic ileus resulted from nirmatrelvir/ritonavir-tacrolimus drug-drug interaction in a systemic lupus erythematosus patient with COVID-19

in Predictive Toxicology

Wei Zhang
Xingguo Zhang
Jinming Han
Wen Zhang
Jiarui Xu
Xin Zhang
Hongjun Bian
Chong Meng
Deya Shang
Yi Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1389187

1,541 views
1 citation

Original Research

Published on 19 Mar 2024

Safety assessment of Acori Tatarinowii Rhizoma: acute and subacute oral toxicity

in Predictive Toxicology

Jia Liu
Xin Ping
Shu-jie Sun
Jiali Yang
Ye Lu
Lin Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1377876

1,694 views

Review

Published on 19 Mar 2024

Emerging insights into the impacts of heavy metals exposure on health, reproductive and productive performance of livestock

in Predictive Toxicology

Ali Afzal
Naima Mahreen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1375137

6,273 views
9 citations

Original Research

Published on 18 Mar 2024

Product labeling accuracy and contamination analysis of commercially available cannabidiol product samples

in Predictive Toxicology

Barry E. Gidal
Ryan Vandrey
Chela Wallin
Sean Callan
Alan Sutton
Timothy B. Saurer
Jennifer L. Triemstra

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1335441

3,322 views
8 citations

Original Research

Published on 14 Mar 2024

Post-marketing safety evaluation of lurbinectedin: a pharmacovigilance analysis based on the FAERS database

in Predictive Toxicology

Zhao Li
Changying Guo
Xingfei Liu
Zhengzhou Qiu
Ruilin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1368763

2,947 views

Original Research

Published on 07 Mar 2024

Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure

in Predictive Toxicology

Johanna Ebmeyer
Abdulkarim Najjar
Daniela Lange
Mareike Boettcher
Silja Voß
Katrin Brandmair
Jaqueline Meinhardt
Jochen Kuehnl
Nicola J. Hewitt
Christopher-Tilman Krueger

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1345992

3,497 views
3 citations

Case Report

Published on 07 Mar 2024

Case Report: Minocycline-induced drug reaction with eosinophilia and systemic symptoms syndrome: a case report and literature review

in Predictive Toxicology

Zhe Zhao
Ming Lu
Yingqiu Ying

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1355774

2,204 views
1 citation

Original Research

Published on 06 Mar 2024

Evaluation of the lncRNA-miRNA-mRNA ceRNA network in lungs of miR-147 −/− mice

in Predictive Toxicology

Nan Zhang
Gui-Yuan Song
Qing-Hua Yu
Xin-Ming Fan
Wen-Shuo Zhang
Yong-Jian Hu
Tian-Zhu Chao
Yao-Yao Wu
Shu-Yan Duan
Fei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1335374

1,310 views
2 citations

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Articles

Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells

Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion

A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy

Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling

Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis

Delineation of renal protein profiles in aristolochic acid I-induced nephrotoxicity in mice by label-free quantitative proteomics

Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy

Exploiting the predictive power of educated spheroids to detect immune-mediated idiosyncratic drug-induced liver injury: the case of troglitazone

Case report: Paralytic ileus resulted from nirmatrelvir/ritonavir-tacrolimus drug-drug interaction in a systemic lupus erythematosus patient with COVID-19

Safety assessment of Acori Tatarinowii Rhizoma: acute and subacute oral toxicity

Emerging insights into the impacts of heavy metals exposure on health, reproductive and productive performance of livestock

Product labeling accuracy and contamination analysis of commercially available cannabidiol product samples

Post-marketing safety evaluation of lurbinectedin: a pharmacovigilance analysis based on the FAERS database

Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure

Case Report: Minocycline-induced drug reaction with eosinophilia and systemic symptoms syndrome: a case report and literature review

Evaluation of the lncRNA-miRNA-mRNA ceRNA network in lungs of miR-147 −/− mice