Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 29 Oct 2024

Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment

in Predictive Toxicology

Christopher J. Morris
Michael G. Rolf
Linda Starnes
Inmaculada C. Villar
Amy Pointon
Holly Kimko
Giovanni Y. Di Veroli

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1402462

658 views

Original Research

Published on 23 Oct 2024

Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform

in Predictive Toxicology

Caitlin Lynch
Ryan Margolis
Jacob Niebler
Jameson Travers
Srilatha Sakamuru
Tongan Zhao
Carleen Klumpp-Thomas
Ruili Huang
Menghang Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1448744

1,047 views

Original Research

Published on 18 Oct 2024

Monocrotaline-mediated autophagy via inhibiting PI3K/AKT/mTOR pathway induces apoptosis in rat hepatocytes

in Predictive Toxicology

Yazhou Guo
Yang Yuan
Ruibo Wang
Jun Bai
Yanqing Jia
Xinxin Qiu
Huafeng Niu
Long Li
Yan Luo
Baoyu Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1499116

846 views

Original Research

Published on 03 Oct 2024

Development and validation of PBPK models for genistein and daidzein for use in a next-generation risk assessment

in Predictive Toxicology

A. Najjar
D. Lange
C. Géniès
J. Kuehnl
A. Zifle
C. Jacques
E. Fabian
N. Hewitt
A. Schepky

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1421650

1,211 views
1 citation

Review

Published on 24 Sep 2024

Apoptosis, autophagy, ferroptosis, and pyroptosis in cisplatin-induced ototoxicity and protective agents

in Predictive Toxicology

Dingyuan Dai
Chao Chen
Chen Lu
Yu Guo
Qi Li
Chen Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1430469

1,662 views

Original Research

Published on 24 Sep 2024

Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept

in Predictive Toxicology

Kaiyue Ma
Lu Sun
Chunxue Jia
Hongqian Kui
Jiaqi Xie
Shidan Zang
Shixin Huang
Jinfeng Que
Chuanxin Liu
Jianmei Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1378758

1,037 views

Original Research

Published on 28 Aug 2024

A real-world pharmacovigilance study of KRAS G12C mutation inhibitors based on the food and drug administration adverse event reporting system

in Predictive Toxicology

Lisha Wu
Maosheng Xu
Xueqin Li
Dilinuer Aierken
Jinxiu Yu
Tao Qin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1418469

1,775 views

Original Research

Published on 21 Aug 2024

Comprehensive hepatotoxicity prediction: ensemble model integrating machine learning and deep learning

in Predictive Toxicology

Muhammad Zafar Irshad Khan
Jia-Nan Ren
Cheng Cao
Hong-Yu-Xiang Ye
Hao Wang
Ya-Min Guo
Jin-Rong Yang
Jian-Zhong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1441587

1,214 views

Original Research

Published on 14 Aug 2024

Predicting non-chemotherapy drug-induced agranulocytosis toxicity through ensemble machine learning approaches

in Predictive Toxicology

Xiaojie Huang
Xiaochun Xie
Shaokai Huang
Shanshan Wu
Lina Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1431941

1,078 views

Original Research

Published on 09 Aug 2024

Assessing the immunogenicity risk of salmon calcitonin peptide impurities using in silico and in vitro methods

in Predictive Toxicology

Brian J. Roberts
Aimee E. Mattei
Kristina E. Howard
James L. Weaver
Hao Liu
Sandra Lelias
William D. Martin
Daniela Verthelyi
Eric Pang
Katie J. Edwards

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1363139

2,885 views

Original Research

Published on 24 Jul 2024

Treatment of an accident of imidacloprid poisoning

in Predictive Toxicology

Mei Zeng
Mengdi Shi
Xiangdong Jian
Laidong Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1421437

2,044 views

Original Research

Published on 17 Jul 2024

Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment

in Predictive Toxicology

Andreas H. Göller
Sandra Johanssen
Adam Zalewski
Verena Ziegler

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1415266

1,564 views

Case Report

Published on 17 Jul 2024

Fatal hyperpyrexia caused by xylazine: a case report

in Predictive Toxicology

Ping Dai
Yanqing Chen
Xianqin Luo
Zhiqiang Zhou
Mengdi Shi
Aerbusili Genjiafu
Xiangdong Jian

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437960

913 views
1 citation

Original Research

Published on 17 Jul 2024

Analysis of eplerenone in the FDA adverse event reporting system (FAERS) database: a focus on overall patient population and gender-specific subgroups

in Predictive Toxicology

Xin Guan
Yusi Yang
Xinru Li
Yue Feng
Jizhen Li
Xuewen Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1417951

1,985 views

Original Research

Published on 12 Jul 2024

Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens

in Predictive Toxicology

Yaning Shi
Zhixin Gao
Bing Xu
Junbing Mao
Yue Wang
Zongping Liu
Jicang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1440877

1,384 views

Original Research

Published on 20 Jun 2024

Toxicological safety assessment of a water extract of Lithocarpus litseifolius by a 90-day repeated oral toxicity study in rats

in Predictive Toxicology

Jinfeng Ma
Yujia Wei
Jingfeng Sun
Fang Tan
Penghe Liu
Guangqiu Qin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1385550

659 views

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Articles

Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment

Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform

Monocrotaline-mediated autophagy via inhibiting PI3K/AKT/mTOR pathway induces apoptosis in rat hepatocytes

Development and validation of PBPK models for genistein and daidzein for use in a next-generation risk assessment

Apoptosis, autophagy, ferroptosis, and pyroptosis in cisplatin-induced ototoxicity and protective agents

Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept

A real-world pharmacovigilance study of KRAS G12C mutation inhibitors based on the food and drug administration adverse event reporting system

Comprehensive hepatotoxicity prediction: ensemble model integrating machine learning and deep learning

Predicting non-chemotherapy drug-induced agranulocytosis toxicity through ensemble machine learning approaches

Assessing the immunogenicity risk of salmon calcitonin peptide impurities using in silico and in vitro methods

Treatment of an accident of imidacloprid poisoning

Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment

Fatal hyperpyrexia caused by xylazine: a case report

Analysis of eplerenone in the FDA adverse event reporting system (FAERS) database: a focus on overall patient population and gender-specific subgroups

Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens

Toxicological safety assessment of a water extract of Lithocarpus litseifolius by a 90-day repeated oral toxicity study in rats