Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 14 Feb 2020

Development of Prediction Models for Drug-Induced Cholestasis, Cirrhosis, Hepatitis, and Steatosis Based on Drug and Drug Metabolite Structures

in Predictive Toxicology

Hyun Kil Shin
Myung-Gyun Kang
Daeui Park
Tamina Park
Seokjoo Yoon

Frontiers in Pharmacology

doi 10.3389/fphar.2020.00067

5,964 views
17 citations

Original Research

Published on 31 Jan 2020

Protein Kinase D1 (PKD1) Is a New Functional Non-Genomic Target of Bisphenol A in Breast Cancer Cells

in Predictive Toxicology

Messaouda Merzoug-Larabi
Ilige Youssef
Ai Thu Bui
Christine Legay
Sophia Loiodice
Sophie Lognon
Sylvie Babajko
Jean-Marc Ricort

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01683

3,687 views
6 citations

Original Research

Published on 10 Jan 2020

Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway

in Predictive Toxicology

Huan He
Liang Wang
Yang Qiao
Qing Zhou
Hongwei Li
Shuping Chen
Dong Yin
Qing Huang
Ming He

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01531

12,714 views
96 citations

Original Research

Published on 08 Jan 2020

Narrowing the Gap Between In Vitro and In Vivo Genetic Profiles by Deconvoluting Toxicogenomic Data In Silico

in Predictive Toxicology

Yuan Liu
Runyu Jing
Zhining Wen
Menglong Li

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01489

4,018 views
9 citations

Perspective

Published on 10 Dec 2019

In Vitro Research Reproducibility: Keeping Up High Standards

in Predictive Toxicology

Cordula Hirsch
Stefan Schildknecht

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01484

23,887 views
105 citations

Original Research

Published on 29 Nov 2019

Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll® Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico, In Vitro, and Human Biomonitoring Data

in Predictive Toxicology

Kevin McNally
Craig Sams
George Loizou

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01394

3,690 views
10 citations

Original Research

Published on 26 Nov 2019

Additive Dose Response Models: Defining Synergy

in Predictive Toxicology

Simone Lederer
Tjeerd M. H. Dijkstra
Tom Heskes

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01384

17,315 views
38 citations

Original Research

Published on 14 Nov 2019

Understanding the Bacterial Response to Mycotoxins: The Transcriptomic Analysis of Deoxynivalenol-Induced Changes in Devosia mutans 17-2-E-8

in Predictive Toxicology

Yousef I. Hassan
Jian Wei He
Dion Lepp
Ting Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01098

3,496 views
10 citations

Case Report

Published on 08 Nov 2019

Hemolytic Anemia and Reactive Thrombocytosis Associated With Cefoperazone/Sulbactam

in Predictive Toxicology

Ling Zhou
Jianan Bao
Jingjing Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01342

8,032 views
7 citations

Review

Published on 06 Nov 2019

Phthalate-Induced Fetal Leydig Cell Dysfunction Mediates Male Reproductive Tract Anomalies

in Predictive Toxicology

Yiyan Wang
Chaobo Ni
Xiaoheng Li
Zhenkun Lin
Qiqi Zhu
Linxi Li
Ren-Shan Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01309

5,812 views
37 citations

Methods

Published on 06 Nov 2019

Unpredictable Nanoparticle Retention in Commonly Used Plastic Syringes Introduces Dosage Uncertainties That May Compromise the Accuracy of Nanomedicine and Nanotoxicology Studies

in Predictive Toxicology

Uwe Holzwarth
Unai Cossío
Jordi Llop
Wolfgang G. Kreyling

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01293

3,862 views
10 citations

Correction

Published on 24 Oct 2019

Corrigendum: Interference With Coagulation Cascade as a Novel Approach to Counteract Cisplatin-Induced Acute Tubular Necrosis; an Experimental Study in Rats

in Predictive Toxicology

Mohamed G. Ewees
Basim A. S. Messiha
Ali A. Abo-Saif
Asmaa M. A. Bayoumi
Mohamed S. Abdel-Bakky

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01259

1,226 views
2 citations

Original Research

Published on 18 Oct 2019

Zearalenone and ß-Zearalenol But Not Their Glucosides Inhibit Heat Shock Protein 90 ATPase Activity

in Predictive Toxicology

Juan Antonio Torres Acosta
Herbert Michlmayr
Mehrdad Shams
Wolfgang Schweiger
Gerlinde Wiesenberger
Rudolf Mitterbauer
Ulrike Werner
David Merz
Marie-Theres Hauser
Christian Hametner

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01160

3,810 views
6 citations

Original Research

Published on 17 Oct 2019

Construction and Analysis of circRNA-miRNA-mRNA Molecular Regulatory Networks During Herba Gelsemium elegans Intoxication

in Predictive Toxicology

Yinghao Wang
Shuisheng Wu
Ce Yang
Hanyun Gao
Hongmin Yu
Xuehua Lu
Shugang Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01217

3,303 views
6 citations

Original Research

Published on 16 Oct 2019

Toxicity Study of 28-Day Subcutaneous Injection of Arctigenin in Beagle Dogs

in Predictive Toxicology

Jie Li
Yun-gang Lv
Li-hong Pan
Fang-fang Yao
Tao Peng
Yu-jun Tan
Gui-Min Zhang
Zhong Liu
Jing-chun Yao
Yu-shan Ren

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01218

5,617 views
4 citations

Original Research

Published on 11 Oct 2019

Akt Regulated Phosphorylation of GSK-3β/Cyclin D1, p21 and p27 Contributes to Cell Proliferation Through Cell Cycle Progression From G1 to S/G2M Phase in Low-Dose Arsenite Exposed HaCat Cells

in Predictive Toxicology

Yao Chen
Xudan Liu
Huanhuan Wang
Shiyi Liu
Nannan Hu
Xin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01176

4,818 views
42 citations

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Articles

Development of Prediction Models for Drug-Induced Cholestasis, Cirrhosis, Hepatitis, and Steatosis Based on Drug and Drug Metabolite Structures

Protein Kinase D1 (PKD1) Is a New Functional Non-Genomic Target of Bisphenol A in Breast Cancer Cells

Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway

Narrowing the Gap Between In Vitro and In Vivo Genetic Profiles by Deconvoluting Toxicogenomic Data In Silico

In Vitro Research Reproducibility: Keeping Up High Standards

Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll® Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico, In Vitro, and Human Biomonitoring Data

Additive Dose Response Models: Defining Synergy

Understanding the Bacterial Response to Mycotoxins: The Transcriptomic Analysis of Deoxynivalenol-Induced Changes in Devosia mutans 17-2-E-8

Hemolytic Anemia and Reactive Thrombocytosis Associated With Cefoperazone/Sulbactam

Phthalate-Induced Fetal Leydig Cell Dysfunction Mediates Male Reproductive Tract Anomalies

Unpredictable Nanoparticle Retention in Commonly Used Plastic Syringes Introduces Dosage Uncertainties That May Compromise the Accuracy of Nanomedicine and Nanotoxicology Studies

Corrigendum: Interference With Coagulation Cascade as a Novel Approach to Counteract Cisplatin-Induced Acute Tubular Necrosis; an Experimental Study in Rats

Zearalenone and ß-Zearalenol But Not Their Glucosides Inhibit Heat Shock Protein 90 ATPase Activity

Construction and Analysis of circRNA-miRNA-mRNA Molecular Regulatory Networks During Herba Gelsemium elegans Intoxication

Toxicity Study of 28-Day Subcutaneous Injection of Arctigenin in Beagle Dogs

Akt Regulated Phosphorylation of GSK-3β/Cyclin D1, p21 and p27 Contributes to Cell Proliferation Through Cell Cycle Progression From G1 to S/G2M Phase in Low-Dose Arsenite Exposed HaCat Cells