Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 24 Jan 2025

MDTR: a knowledge-guided interpretable representation for quantifying liver toxicity at transcriptomic level

in Predictive Toxicology

Inyoung Sung
Sangseon Lee
Dongmin Bang
Jungseob Yi
Sunho Lee
Sun Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1398370

208 views

Original Research

Accepted on 17 Jan 2025

Safety assessment of rosuvastatin-fenofibrate combination in the treatment of hyperlipidemia based on FDA's Adverse Event Reporting System Database

in Predictive Toxicology

Qun Li
Wenya Shan
Saiwei Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1415701

Original Research

Accepted on 17 Jan 2025

Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways

in Predictive Toxicology

Qingshan Tang
Jiachen Dong
Feng Zhang
Dan Zhao
Qi Yang
Jiayu Wen
Yuhao Sun
Ji-Fu Wei
Zhixian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1489210

Editorial

Accepted on 10 Jan 2025

Introduction to the Research Topic: Advancements in Predictive Toxicology Methods

in Predictive Toxicology

Sankalp Jain
Serena Manganelli
Vitalina Gryshkova
Maria Armanda Rodrigues
Aniket Magarkar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1556352

Case Report

Published on 09 Jan 2025

Case report: Accidental aconitine poisoning caused by the inappropriate use of a type of Chinese patent medicine

in Predictive Toxicology

Ruikai Shang
Hongyu Liu
Qiaoxin Tian
Yuru Liu
Xiangdong Jian
Qilu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1426006

182 views

Review

Published on 09 Jan 2025

Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies

in Predictive Toxicology

Zhichao Liu
Yongkang Gan
Zhen Shen
Siqi Cai
Xizhen Wang
Yong Li
Xiaofeng Li
Huanjie Fu
Jinhong Chen
Ningcen Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1527901

377 views

Case Report

Published on 07 Jan 2025

Ceftriaxone-induced hemolytic anemia managed successfully in a 54-year-old woman: a case report and literature review

in Predictive Toxicology

Liqian Zhang
Wenfeng Huang
Jiakai Xu
Yunxing Li
Jihong Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505366

260 views

Original Research

Published on 06 Jan 2025

CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium

in Predictive Toxicology

Zhixuan Chen
Huayi Qu
Jian Sun
Tao Wang
Yan Yuan
Jianhong Gu
Jianchun Bian
Zongping Liu
Hui Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1533188

289 views

Original Research

Accepted on 02 Jan 2025

Drug-induced dermatomyositis: a pharmacovigilance study of the FDA adverse event reporting system

in Predictive Toxicology

Jianing Bi
Hanzhang Xie
Yixuan Yang
Qiaochu Chen
Bingnan Cui
ZhanShuo Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526836

Original Research

Published on 17 Dec 2024

Quantitative study on hepatic genotoxicity of neodymium and its molecular mechanisms based on Benchmark Dose method

in Predictive Toxicology

Ning Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1484111

473 views

Original Research

Published on 28 Nov 2024

Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate

in Predictive Toxicology

Chenquan Lin
Rui Ma
Xiao Zeng
Bikui Zhang
Ting Cao
Shimeng Jiao
Hui Chen
Yifang He
Mouze Liu
Hualin Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423214

647 views

Case Report

Published on 26 Nov 2024

Case Report: Sudden death caused by methylene chloride poisoning

in Predictive Toxicology

Ruikai Shang
Qiaoxin Tian
Yuru Liu
Hongyu Liu
Xiangxing Zhang
Mengdi Shi
Xiangdong Jian
Qilu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1471744

627 views

Perspective

Published on 26 Nov 2024

Mitigating Paxlovid™-induced drug‒drug interaction toxicity: an in silico insight

in Predictive Toxicology

Giang H. Ta
Max K. Leong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1496630

498 views

Original Research

Published on 11 Nov 2024

Delayed immune-related adverse events profile associated with immune checkpoint inhibitors: a real-world analysis

in Predictive Toxicology

Yana Yang
Linman Li
Jing Tian
Linwen Ma
Yaoxin Wu
Qian Luo
Yan Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1453429

978 views

Original Research

Published on 05 Nov 2024

DDIT4/mTOR signaling pathway mediates cantharidin-induced hepatotoxicity and cellular damage

in Predictive Toxicology

Wenchao Tang
Yue Pan
Can Zhu
Didong Lou
Fang Peng
Qin Shi
Yuanyuan Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1480512

964 views

Original Research

Published on 29 Oct 2024

Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment

in Predictive Toxicology

Christopher J. Morris
Michael G. Rolf
Linda Starnes
Inmaculada C. Villar
Amy Pointon
Holly Kimko
Giovanni Y. Di Veroli

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1402462

624 views

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Articles

MDTR: a knowledge-guided interpretable representation for quantifying liver toxicity at transcriptomic level

Safety assessment of rosuvastatin-fenofibrate combination in the treatment of hyperlipidemia based on FDA's Adverse Event Reporting System Database

Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways

Introduction to the Research Topic: Advancements in Predictive Toxicology Methods

Case report: Accidental aconitine poisoning caused by the inappropriate use of a type of Chinese patent medicine

Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies

Ceftriaxone-induced hemolytic anemia managed successfully in a 54-year-old woman: a case report and literature review

CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium

Drug-induced dermatomyositis: a pharmacovigilance study of the FDA adverse event reporting system

Quantitative study on hepatic genotoxicity of neodymium and its molecular mechanisms based on Benchmark Dose method

Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate

Case Report: Sudden death caused by methylene chloride poisoning

Mitigating Paxlovid™-induced drug‒drug interaction toxicity: an in silico insight

Delayed immune-related adverse events profile associated with immune checkpoint inhibitors: a real-world analysis

DDIT4/mTOR signaling pathway mediates cantharidin-induced hepatotoxicity and cellular damage

Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment