Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Original Research

Accepted on 25 Sep 2025

Identification of Galangin as a Therapeutic Candidate for Primary Biliary Cholangitis via Systematic Druggable Genome-Wide Mendelian Randomization Analysis and Experimental Validation

in Gastrointestinal and Hepatic Pharmacology

Weirui Ren
Chuang Zhang
Hanyan Wang
Hongzhao Song
Xuejuan Zhu
Zhijun Zhang
Suxian Zhao
Junmin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674693

Original Research

Accepted on 23 Sep 2025

Efficacy and safety of Live Combined Bacillus subtilis and Enterococcus faecium in patients with constipation: a meta-analysis of randomized controlled trials

in Gastrointestinal and Hepatic Pharmacology

Wenwen Li
Yingying Liang
Guangcai Li
Dandan Yang
Xiaoqian Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688544

306 views

Original Research

Published on 23 Sep 2025

Novel insights into the hepatoprotective mechanisms of SGLT2 inhibitor empagliflozin in Zucker diabetic fatty rats

in Gastrointestinal and Hepatic Pharmacology

F. Comella
A. Aragón-Herrera
S. Melini
N. Opallo
S. Feijóo-Bandín
N. P. Navatti
G. Mattace Raso
O. Gualillo
C. Pirozzi
F. Lago-Paz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1649630

1,448 views

Review

Accepted on 19 Sep 2025

The Endocannabinoid System as a Therapeutic Target in Intestinal Fibrosis

in Gastrointestinal and Hepatic Pharmacology

Zofia Misztal
Alicja Kaśniewska-Kosińska
Maria Wołyniak
Ewa Malecka-Wojciesko
Adam Fabisiak

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669951

1,037 views

Original Research

Accepted on 19 Sep 2025

Barnesiella intestinihominis improves gut microbiota disruption and intestinal barrier integrity in mice with impaired glucose regulation

in Gastrointestinal and Hepatic Pharmacology

Xiaojia Liu
Ling Wang
Bing Huang
Yi Jiao
Yaqun Guan
Rebiya Nuli

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1635579

919 views

Systematic Review

Published on 19 Sep 2025

Comparative gastrointestinal adverse effects of GLP-1 receptor agonists and multi-target analogs in type 2 diabetes: a Bayesian network meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Xingmiao Xie
Shuiyuan Yang
Shuzhen Deng
Yuying Liu
Zhibin Xu
Binghong He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1613610

956 views

Original Research

Published on 19 Sep 2025

Comparative efficacy of postoperative adjuvant transcatheter arterial chemoembolization and hepatic artery infusion chemotherapy in patients with BCLC stage 0-B hepatocellular carcinoma at high risk of recurrence following radical resection

in Gastrointestinal and Hepatic Pharmacology

Xu Feng
Yupei Ao
Jiarui Liu
Jue Yuan
Zhengrong Shi
Chengjia Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657794

1,263 views

Original Research

Accepted on 17 Sep 2025

Proton pump inhibitor use and pancreatic risk: evidence from the UK Biobank participants and animal experiments

in Gastrointestinal and Hepatic Pharmacology

Xin Gao
Zouhua Xu
Qingxie Liu
Chenchen Yuan
Xiaowu Dong
Xiaolei Shi
Qingtian Zhu
Keyan Wu
Hongwei Xu
Jiajia Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673200

485 views

Original Research

Published on 15 Sep 2025

Mechanistic study on the restoration of intestinal barrier integrity and alleviation of inflammatory bowel disease by rhynchophylline via the AhR-NR4A1 pathway

in Gastrointestinal and Hepatic Pharmacology

Xuwen Mao
Lufeng Cheng
Yu Liu
Yuche Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1629012

845 views

Original Research

Published on 12 Sep 2025

Ramucirumab plus paclitaxel as switch maintenance in patients with advanced HER2-negative gastric or gastro-oesophageal junction cancer: a cost-effectiveness analysis

in Gastrointestinal and Hepatic Pharmacology

Jiefeng Luo
Zhengxiong Li
Qiong Du
Jiyong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616826

1,155 views

Review

Published on 10 Sep 2025

Mechanisms and advantages of natural derived small molecule compounds in the prevention and treatment of colorectal cancer: a review

in Gastrointestinal and Hepatic Pharmacology

Ming-Jie Liao
Hao-Yu Dong
Gang Chen
Wei-Wei Li
Guo-Feng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658493

1,321 views

Systematic Review

Published on 09 Sep 2025

Efficacy and safety of fruquintinib in the treatment of colorectal cancer: a systematic review and meta-analysis of studies in China

in Gastrointestinal and Hepatic Pharmacology

Yuan Feng
Yu Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590782

1,093 views

Original Research

Published on 05 Sep 2025

Pharmacological characterization of linaprazan glurate (X842), a novel potassium-competitive acid blocker, in vitro and in vivo

in Gastrointestinal and Hepatic Pharmacology

Ming Lu
Yi Cui
Nailin Li
Yan He
Ling Zhou
Jin Xiu
Pingsheng Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636523

1,049 views

Original Research

Accepted on 03 Sep 2025

Pretreatment with Astragalus polysaccharide alleviates heat stroke–induced intestinal injury in mice

in Gastrointestinal and Hepatic Pharmacology

Niqi Shan
Linxiao Wang
Chujun Duan
Yilin Wu
Yangmengjie Jing
Hanyin Fan
Shuai Wang
Yuling Wang
Shijia Wang
Hui Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1612852

737 views

Mini Review

Published on 03 Sep 2025

NASH-related Hepatocellular carcinoma: current therapeutic approaches and the emerging role of sodium homeostasis as a novel targeting strategy

in Gastrointestinal and Hepatic Pharmacology

Abdulsalam Ashkar
Simone Fiorilla
Francesco Tasso
Rita Carini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671001

1,469 views

Perspective

Published on 01 Sep 2025

The macrogol revolution in the treatment of chronic constipation. A short history of laxatives

in Gastrointestinal and Hepatic Pharmacology

Enrico Stefano Corazziari

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662224

905 views