Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Systematic Review

Accepted on 17 Oct 2025

The Impact of Proton Pump Inhibitor Exposure on Pneumonia: An Updated Meta-Analysis Based on Randomized Controlled Trials

in Gastrointestinal and Hepatic Pharmacology

Zhujun Wu
Yixuan Wu
Zhiyi Xiang
Yi Qiu
Wangyi Xuan
Shengying Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713256

115 views

Perspective

Accepted on 17 Oct 2025

Not Quite a Cure Yet: Unlocking the Unfulfilled Promise of Live Biotherapeutics for Disease Treatment

in Gastrointestinal and Hepatic Pharmacology

Andrea Verdugo-Meza
Han M. Chiang
Emeran A Mayer
Deanna L Gibson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695976

Original Research

Accepted on 15 Oct 2025

Oral administration of the probiotic strain Lactobacillus helveticus BGRA43 reduces high-fat diet–induced hepatic steatosis in mice and restores gut microbiota composition

in Gastrointestinal and Hepatic Pharmacology

Ana Teofilović
Milos Vrataric
Biljana Bursać
Ljupka Gligorovska
Danijela Vojnović Milutinović
Nemanja Stanisavljević
Ivana Strahinic
Danijela M Mišić
Filip Nikolić
Bojan Pavlović

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688777

Original Research

Accepted on 15 Oct 2025

Rituximab in PR3-ANCA Positive Patients with Moderately to Severely Active Ulcerative Colitis: A Multicenter Real-World Pilot Study

in Gastrointestinal and Hepatic Pharmacology

Qi Yu
Yiyu Cheng
Huan Wang
Yidong Chen
Fang Liu
Xiaopeng Zhang
Xiaoyu Fu
Jiamin Li
Junrong Li
Ying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621795

139 views

Clinical Trial

Accepted on 15 Oct 2025

Determination of the Effective Dose of Oliceridine Combined with Propofol Using the Modified Dixon's Up-and-Down Method in Painless Gastroscopy

in Gastrointestinal and Hepatic Pharmacology

Jinfeng Cao
Xiaoyu Gu
Xinyang Zhang
Yao Cheng
Chunling Jiang
Liuqin Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620158

Original Research

Published on 15 Oct 2025

Efficacy and safety of live combined Bacillus subtilis and Enterococcus faecium in patients with constipation: a meta-analysis of randomized controlled trials

in Gastrointestinal and Hepatic Pharmacology

Wenwen Li
Yingying Liang
Guangcai Li
Dandan Yang
Xiaoqian Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688544

1,107 views

Original Research

Accepted on 13 Oct 2025

Effects of different opioids on the contractile tension of isolated rat intestinal smooth muscle

in Gastrointestinal and Hepatic Pharmacology

Chen Yang
jianying hu
Yan Cheng
Shen Sun
Shaoqiang Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617936

Mini Review

Published on 13 Oct 2025

The role of cuproptosis in the occurrence and development of gastric cancer

in Gastrointestinal and Hepatic Pharmacology

Ling Lu
Wenhui Yang
Yuning Gu
Longtao Jin
Zhaofeng Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1664200

368 views

Original Research

Published on 09 Oct 2025

Identification of galangin as a therapeutic candidate for primary biliary cholangitis via systematic druggable genome-wide Mendelian randomization analysis and experimental validation

in Gastrointestinal and Hepatic Pharmacology

Weirui Ren
Chuang Zhang
Hanyan Wang
Hongzhao Song
Xuejuan Zhu
Zhijun Zhang
Suxian Zhao
Junmin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674693

1,150 views

Original Research

Published on 08 Oct 2025

Barnesiella intestinihominis improves gut microbiota disruption and intestinal barrier integrity in mice with impaired glucose regulation

in Gastrointestinal and Hepatic Pharmacology

Xiaojia Liu
Ling Wang
Bing Huang
Yi Jiao
Yaqun Guan
Rebiya Nuli

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1635579

1,290 views

Original Research

Published on 08 Oct 2025

Proton pump inhibitor use and pancreatic risk: evidence from the UK biobank participants and animal experiments

in Gastrointestinal and Hepatic Pharmacology

Xin Gao
Zouhua Xu
Qingxie Liu
Chenchen Yuan
Xiaowu Dong
Xiaolei Shi
Qingtian Zhu
Keyan Wu
Hongwei Xu
Jiajia Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673200

882 views

Review

Published on 03 Oct 2025

The endocannabinoid system as a therapeutic target in intestinal fibrosis

in Gastrointestinal and Hepatic Pharmacology

Zofia Misztal
Alicja Kaśniewska-Kosińska
Maria Wołyniak
Ewa Małecka-Wojciesko
Adam Fabisiak

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669951

1,606 views

Original Research

Accepted on 29 Sep 2025

The use of Magnesium Sulfate can reduce the mortality risk of cirrhosis patients: A Retrospective Cohort Study

in Gastrointestinal and Hepatic Pharmacology

Boxian Chen
Yuping Yang
Mouji Liang
Zhe Huang
Shicai Ye
Yujie Huang
Ruyin Ye
Liping Zhan
Yanqi Kou
Jieming Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551495

534 views

Original Research

Accepted on 29 Sep 2025

Therapeutic Effects of Three-Strain Probiotic Combination on Slow Transit Constipation: Mechanistic Insights into MAPK Signaling Pathway and Gut Microbiota Restoration

in Gastrointestinal and Hepatic Pharmacology

Liya Liu
Peiyao Li
Youqin Chen
Guangqing Yang
Ying Cheng
Sijia Liu
Zhang Xinran
Yulun Wu
Qihong Liu
Peilin Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684442

372 views

Original Research

Published on 26 Sep 2025

Pretreatment with Astragalus polysaccharide alleviates heat stroke–induced intestinal injury in mice

in Gastrointestinal and Hepatic Pharmacology

Niqi Shan
Linxiao Wang
Chujun Duan
Yilin Wu
Yangmengjie Jing
Hanyin Fan
Shuai Wang
Yuling Wang
Shijia Wang
Hui Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1612852

1,707 views

Original Research

Published on 23 Sep 2025

Novel insights into the hepatoprotective mechanisms of SGLT2 inhibitor empagliflozin in Zucker diabetic fatty rats

in Gastrointestinal and Hepatic Pharmacology

F. Comella
A. Aragón-Herrera
S. Melini
N. Opallo
S. Feijóo-Bandín
N. P. Navatti
G. Mattace Raso
O. Gualillo
C. Pirozzi
F. Lago-Paz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1649630

2,501 views