Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 01 Apr 2025

GraphTransNet: predicting epilepsy-related genes using a graph-augmented protein language model

in Experimental Pharmacology and Drug Discovery

Junfeng Xie
Wei Li
Hairu You
Dafang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584625

444 views

Editorial

Published on 01 Apr 2025

Editorial: Reviews in experimental pharmacology and drug discovery 2023: pharmacological management of non-communicable diseases

in Experimental Pharmacology and Drug Discovery

Ali Sharif
Virginia Flores-Morales
Hanan Farouk Aly

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1435638

316 views

Original Research

Accepted on 31 Mar 2025

Quercetin in Shengxian Decoction exhibits anti-ferroptosis protective role in myocardial infarction model via targeting DPP4/ HMOX1, based on network pharmacology and molecular docking

in Experimental Pharmacology and Drug Discovery

Yuming Zhai
Jiamei Fu
Jianfei Yang
Yabin Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1583509

103 views

Original Research

Accepted on 31 Mar 2025

Ginsenoside Rg1 controls CKLF1-mediated apoptosis to reduce hypoxic/reoxygenation injury in HT22 cells

in Experimental Pharmacology and Drug Discovery

Jinping Liang
Xuan Zhu
Yan Yang
Yuchen Zhu
Shasha Liu
Yang Sun
Boyu Kuang
Junpeng Long
Qian Yan
Yuting Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1525605

Original Research

Published on 31 Mar 2025

Machine learning-based transcriptmics analysis reveals BMX, GRB10, and GADD45A as crucial biomarkers and therapeutic targets in sepsis

in Experimental Pharmacology and Drug Discovery

Yanwei Cheng
Haoran Peng
Qiao Chen
Lijun Xu
Lijie Qin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1576467

708 views

Mini Review

Published on 28 Mar 2025

Overcoming immunotherapy resistance in glioblastoma: challenges and emerging strategies

in Experimental Pharmacology and Drug Discovery

Maowu Fu
Bing Xue
Xiuming Miao
Zong Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584688

809 views

Original Research

Published on 27 Mar 2025

Gastrodin attenuates rheumatoid arthritis by targeting KAT8 to inhibit the lactylation of H3K9

in Experimental Pharmacology and Drug Discovery

Yufang Dai
Shunshun Wang
Jiayi Luo
Huiming Yu
Qianqian Du
Shuwan Hou
Minfu Liu
Shan Jiang
Huajiao Xu
Siyi Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559744

1,108 views

Original Research

Published on 27 Mar 2025

Agonist efficacy at the β2AR is driven by the faster association rate of the Gs protein

in Experimental Pharmacology and Drug Discovery

Clare R. Harwood
David A. Sykes
Theo Redfern-Nichols
Owen Underwood
Colin Nicholson
Armin N. Khoshgrudi
Eline J. Koers
Graham Ladds
Stephen J. Briddon
Dmitry B. Veprintsev

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1367991

2,330 views

Original Research

Published on 27 Mar 2025

A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy

in Experimental Pharmacology and Drug Discovery

Yizheng Zu
Min Li
Ruyue Li
Shaohan Ma
Yu’e Yang
Shun Zhang
Yuan Ma
Tiantian Wu
Chunfang Ha

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584463

393 views

Original Research

Published on 27 Mar 2025

Celastrol reduces cisplatin-induced nephrotoxicity by downregulating SNORD3A level in kidney organoids derived from human iPSCs

in Experimental Pharmacology and Drug Discovery

Chongayng Shen
Qizheng Wang
Xun Ye
Yi Zhou
Huayang Xing
Chengjie Pan
Heying Li
Chunjie Wu
Mingliang You

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1464525

646 views

Original Research

Published on 27 Mar 2025

Radiosensitization effect of iridium (III) complex on lung cancer cells via mitochondria apoptosis pathway

in Experimental Pharmacology and Drug Discovery

Yuru Pang
Qiqi Meng
Yangchen Cui
Shiyi Liu
Huihui Jiang
Chenlan Xu
Yan An
Yang Jiao
Qi Zhang
Jihua Nie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562228

647 views

Original Research

Accepted on 26 Mar 2025

Machine learning-driven SLC prognostic signature for glioma: predicting survival and immunotherapy response

in Experimental Pharmacology and Drug Discovery

Yu'e Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585639

117 views

Original Research

Accepted on 26 Mar 2025

Brain-derived uroguanylin as a regulator of postprandial brown adipose tissue activation: a potential therapeutic approach for metabolic disorders

in Experimental Pharmacology and Drug Discovery

Nikola Habek
Martina Ratko
Dora Sedmak
Ivan Banovac
Vladiana Crljen
Milan Kordić
Marina Dobrivojević Radmilović
Siniša Škokić
Martina Tklčić
Anton Mažuranić

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569163

123 views

Review

Published on 26 Mar 2025

The landscape of research on ferroptosis under hypoxic conditions: a bibliometric analysis

in Experimental Pharmacology and Drug Discovery

Di Yu
Yibo Hu
Meijuan Ma
Wenjia Li
Xiaohui Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519000

527 views

Review

Published on 26 Mar 2025

Innovative applications and future perspectives of chromatography-mass spectrometry in drug research

in Experimental Pharmacology and Drug Discovery

Hong Cai
Xue Xing
Ying Su
Chunhui Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529468

469 views

Original Research

Published on 26 Mar 2025

QingGan LiDan capsules improved alcoholic liver injury by regulating liver lipid transport and oxidative stress in mice

in Experimental Pharmacology and Drug Discovery

Zhiwen Fu
Jiafeng Zhou
Hongye Pan
Song Yang
Zhenzhen Pan
Yujia Shen
Jianbiao Yao
Jiangning Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575280

671 views