Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Accepted on 17 Apr 2025

Therapeutic Potential of Zinc 64 Zn Aspartate for Obesity Management: Impact on Oxidative Stress, Lipid Metabolism, Pancreas and Liver in High-Calorie Diet Model

in Experimental Pharmacology and Drug Discovery

Max Temnik
Sergey Gurin
Alexandr Balakin
Roman Byshovets
Olesia Kalmukova
Tetiana Vovk
Tetiana Halenova
Nataliia Raksha
Tetyana Falalyeyeva
Olexiy Savchuk

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543166

120 views

Original Research

Accepted on 17 Apr 2025

Nafamostat Mesylate Augments Survival in Rats Afflicted by Exertional Heat Stroke

in Experimental Pharmacology and Drug Discovery

Qingwei Lin
Zhuqing Luo
Longping He
Lincui Zhong
Qingbo Zeng
Ye Zhou
Qi Chen
Xingping Deng
Xiaomin Song
Qing Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559181

Original Research

Accepted on 17 Apr 2025

Berberine in the Treatment of Radiation-Induced Skin Injury: Insights from Proteomics and Network Pharmacology

in Experimental Pharmacology and Drug Discovery

Jie Zou
Xia-Juan Xiao
Ping Zhang
Xing-Zi Huang
Jing Wang
Chun-Qin Tao
Xiao-Lan Ou
Gong Chen
Ting-Hao He
Long Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542851

Original Research

Accepted on 16 Apr 2025

CS-6-induced p62 accumulation exacerbates DNA damage in colorectal cancer

in Experimental Pharmacology and Drug Discovery

Yitong Gong
Menghan Dong
Xiaofei Feng
Naiyu Zhang
Xuehui Cui
Liushuyue Wang
Chiu-fai Kuok
Jiang Qing Ling
Sixue Bi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1568339

Original Research

Published on 16 Apr 2025

Repurposing major metabolites of lamiaceae family as potential inhibitors of α-synuclein aggregation to alleviate neurodegenerative diseases: an in silico approach

in Experimental Pharmacology and Drug Discovery

Soham Bhattacharya
Neha Gupta
Adrish Dutta
Pijush Kanti Khanra
Ritesh Dutta
Jana Žiarovská
Nikolay T. Tzvetkov
Lucie Severová
Lenka Kopecká
Luigi Milella

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519145

383 views

Review

Published on 16 Apr 2025

Hepatorenal protective effects of essential oils against chemical overexposure induced oxidative damage

in Experimental Pharmacology and Drug Discovery

Faming Jiang
Xiaoyan Huang
Xingying Chen
Yuanhua Xian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580805

283 views

Original Research

Published on 16 Apr 2025

The development of a high-throughput acoustic droplet ejection mass-spectrometry assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of SLC1-A3, -A2 and -A1 in a drug discovery program

in Experimental Pharmacology and Drug Discovery

Yasmin Zuschlag
Antje Pommereau
Jennifer Warkentin
Thomas Licher
Felix Bärenz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544682

388 views

Original Research

Published on 15 Apr 2025

YX-112, a novel celastrol-derived PROTAC, inhibits the development of triple-negative breast cancer by targeting the degradation of multiple proteins

in Experimental Pharmacology and Drug Discovery

Yongxue Gu
Mengmeng Yang
Wenbin Wang
Lihua Li
Ying Ma
Wenshan Liu
Qiang Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571135

299 views

Perspective

Published on 15 Apr 2025

Metabolic anomalies in vitiligo: a new frontier for drug repurposing strategies

in Experimental Pharmacology and Drug Discovery

Alessia Paganelli
Federica Papaccio
Mauro Picardo
Barbara Bellei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546836

469 views

Review

Accepted on 14 Apr 2025

Role and Mechanism of Integrin α5β1 in Bone Formation and Disease

in Experimental Pharmacology and Drug Discovery

Xiaoying Li
Hu Guangxuan
Jinshi Guo
Bo Chang
Tingting Yao
Xuejie Yi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1494062

Original Research

Accepted on 14 Apr 2025

Stress Signaling and Programmed Cell Death in Breast

in Experimental Pharmacology and Drug Discovery

jian xu
xue li
一多贾

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1467504

Original Research

Accepted on 14 Apr 2025

DTGHAT: Multi-molecule heterogeneous graph Transformer based on multi-molecule graph for drug-target identification

in Experimental Pharmacology and Drug Discovery

Xinchen Jiang
Lu Wen
Wenshui Li
Que Deng
Ming Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1596216

Original Research

Published on 14 Apr 2025

Integrating traditional omics and machine learning approaches to identify microbial biomarkers and therapeutic targets in pediatric inflammatory bowel disease

in Experimental Pharmacology and Drug Discovery

Lanlan Li
XuZai Deng
Shuge Wang
Tao Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545392

344 views

Original Research

Accepted on 11 Apr 2025

Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells

in Experimental Pharmacology and Drug Discovery

Ye Yang
Jieyun Zhou
Qiaoying Lv
Qicheng Ni
Baichun Hu
Yulong Wang
Shuning Qu
Guoting Li
Wenjie Yang
Ruihua Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573032

144 views

Original Research

Accepted on 11 Apr 2025

Synergistic Effects of Retinol and Retinyl Palmitate in Alleviating UVB-Induced DNA Damage and Promoting the Homologous Recombination Repair in Keratinocytes

in Experimental Pharmacology and Drug Discovery

Jiangming Zhong
Ling Liang
Nan Zhao
Jing Wang
Peng Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562244

182 views

Original Research

Accepted on 11 Apr 2025

Prognostic Significance and Multivariate Modeling of COL4A Family Genes and HMGA2 in Glioma

in Experimental Pharmacology and Drug Discovery

Aijun Lu
Jiankun Zang
Na Tan
Liping Wei
Ying Liang
Zefeng Tan
Anding Xu
Dan Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591932