Original Research

Accepted on 13 Nov 2024

Dexmedetomidine regulates the anti-oxidation and autophagy of adipose-derived stromal cells under H2O2-induced oxidative stress through Nrf2/p62 pathway and improves the retention rate of autologous fat transplantation Authors and affiliations

in Experimental Pharmacology and Drug Discovery

Zihao Li
Qing Wei
Fangfang Yang
Chen Ke
Tian Li
Yijun Li
Liqun Li
Zhongming Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1453938

Review

Published on 13 Nov 2024

In-depth analysis of lupeol: delving into the diverse pharmacological profile

in Experimental Pharmacology and Drug Discovery

Aminah Dalimunthe
Mega Carensia Gunawan
Zahirah Dhiya Utari
Muhammad Riza Dinata
Princella Halim
Nathasya Estherina S. Pakpahan
Alex Insandus Sitohang
M. Andriansyah Sukarno
Yuandani
Yahdiana Harahap

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1461478

512 views

Original Research

Published on 13 Nov 2024

Glucocorticoids influence on rat hematological parameters and catalase activity

in Experimental Pharmacology and Drug Discovery

Safija Herenda
Ivana Carev
Denis Haskovic
Sabina Prevljak
Sara Causevic
Edhem Haskovic

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1367350

115 views

Review

Published on 13 Nov 2024

β-blockers and statins: exploring the potential off-label applications in breast, colorectal, prostate, and lung cancers

in Experimental Pharmacology and Drug Discovery

Pedro Gabriel Senger Braga
Janaína da Silva Vieira
Aline Rachel Bezerra Gurgel
Patricia Chakur Brum

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423502

169 views

Original Research

Published on 13 Nov 2024

Integration of metabolomics and transcriptomics to reveal anti-immunosuppression mechanism of Lycium barbarum polysaccharide

in Experimental Pharmacology and Drug Discovery

Jiandong Wang
Xue Zhang
Yi Wu
Qianfei Wei
Lingshan Yan
Youli Yu
Yanan Guo
Zhengqin Yu
Pan Wang
Xiaonan Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486739

127 views

Original Research

Published on 13 Nov 2024

Herbal formula xuling-jiangu improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the gut-bone axis

in Experimental Pharmacology and Drug Discovery

Juan Chen
Szetuen Ng
Pengchao Xu
Sainan Chen
Shengqiang Li
Xuan Chen
Lihua Xie
Jirong Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505231

143 views

Original Research

Published on 12 Nov 2024

Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide

in Experimental Pharmacology and Drug Discovery

Dayma Llanes
Robert Rennert
Paul Jänicke
Ibrahim Morgan
Leslie Reguera
Daniel G. Rivera
Manuel G. Ricardo
Ludger A. Wessjohann

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1408091

271 views

Original Research

Published on 12 Nov 2024

Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation

in Experimental Pharmacology and Drug Discovery

Jie Wen
Lingmao Zhao
Zhuohan Li
Chao Pi
Xianhu Feng
Peng Shi
Hongru Yang
Ligang Chen
Xiaodong Wang
Furong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1464626

151 views

Original Research

Accepted on 11 Nov 2024

Cytotoxicity of Natural and Synthetic Cannabinoids and Their Synergistic Antiproliferative Effects with Cisplatin in Human Ovarian Cancer Cells

in Experimental Pharmacology and Drug Discovery

Ying Chen
Huifang Li
Jia Liu
Jie Ni
Qicheng Deng
Haotian He
Panpan Wu
Yinsheng Wan
Navindra P Seeram
Chang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1496131

Original Research

Accepted on 11 Nov 2024

Zebrafish-Based Identification of Anti-seizure Compounds from Natural Products

in Experimental Pharmacology and Drug Discovery

Fuyun Tian
Hongyuan Zuo
Zhidan Wu
Shuoshuo Zheng
Meixuan Ping
Xinni Bin
Zhaobing Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1499309

Review

Accepted on 11 Nov 2024

Therapeutic implications of traditional Chinese medicine in clinically relevant diseases: Perspectives from microRNA-modulated apoptotic signaling

in Experimental Pharmacology and Drug Discovery

Chunjie Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437019

Review

Accepted on 11 Nov 2024

The role of artificial intelligence in drug screening, drug design, and clinical trials

in Experimental Pharmacology and Drug Discovery

Yuyuan Wu
Lijing Ma
Xinyi Li
Jingpeng Yang
Xinyu Rao
Yiru Hu
Jingyi Xi
Lin Tao
Jianjun Wang
Shuiping Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459954

Original Research

Published on 11 Nov 2024

Nanotechnological prospective for enhancing the antibacterial activity of mupirocin and cinnamon essential oil: a combination therapy

in Experimental Pharmacology and Drug Discovery

Bandar Aldhubiab
Rashed M. Almuqbil
Tamer M. Shehata
Wafaa E. Soliman
Heba S. Elsewedy

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1468374

180 views

Original Research

Published on 11 Nov 2024

Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation

in Experimental Pharmacology and Drug Discovery

Gaetano Marverti
Maria Gaetana Moschella
Alice Belardo
Michele Lamesta
Giada Mercanile
Lorenzo Tagliazucchi
Daniele Aiello
Alberto Venturelli
Davide Illuminati
Remo Guerrini

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477318

261 views

Original Research

Published on 06 Nov 2024

Structure-guided drug repurposing identifies aristospan as a potential inhibitor of β-lactamase: insights from virtual screening and molecular dynamics simulations

in Experimental Pharmacology and Drug Discovery

Moyad Shahwan
Mohd Shahnawaz Khan
Azna Zuberi
Nojood Altwaijry
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459822

270 views

Mini Review

Published on 06 Nov 2024

Recent advances in extracellular matrix manipulation for kidney organoid research

in Experimental Pharmacology and Drug Discovery

Ren Wang
Yufei Sui
Qiuyan Liu
Yucui Xiong
Shanshan Li
Wu Guo
Yiwei Xu
Sheng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1472361

177 views

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Articles

Dexmedetomidine regulates the anti-oxidation and autophagy of adipose-derived stromal cells under H2O2-induced oxidative stress through Nrf2/p62 pathway and improves the retention rate of autologous fat transplantation Authors and affiliations

In-depth analysis of lupeol: delving into the diverse pharmacological profile

Glucocorticoids influence on rat hematological parameters and catalase activity

β-blockers and statins: exploring the potential off-label applications in breast, colorectal, prostate, and lung cancers

Integration of metabolomics and transcriptomics to reveal anti-immunosuppression mechanism of Lycium barbarum polysaccharide

Herbal formula xuling-jiangu improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the gut-bone axis

Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide

Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation

Cytotoxicity of Natural and Synthetic Cannabinoids and Their Synergistic Antiproliferative Effects with Cisplatin in Human Ovarian Cancer Cells

Zebrafish-Based Identification of Anti-seizure Compounds from Natural Products

Therapeutic implications of traditional Chinese medicine in clinically relevant diseases: Perspectives from microRNA-modulated apoptotic signaling

The role of artificial intelligence in drug screening, drug design, and clinical trials

Nanotechnological prospective for enhancing the antibacterial activity of mupirocin and cinnamon essential oil: a combination therapy

Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation

Structure-guided drug repurposing identifies aristospan as a potential inhibitor of β-lactamase: insights from virtual screening and molecular dynamics simulations

Recent advances in extracellular matrix manipulation for kidney organoid research