Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 28 Apr 2025

Irisin attenuates cardiac injury and improves prognosis in rats with hemorrhagic shock by maintaining mitochondrial homeostasis via the AMPK/Drp1 pathway

in Experimental Pharmacology and Drug Discovery

Zheng Zhang
Yufang Zhang
Xiaofang Zou
Jiake Li
Yunfei Chi
Hailiang Bai
Bin Wei
Huiting Yun
Quanxi Zhang
Weihua Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560608

3,257 views
1 citation

Original Research

Published on 28 Apr 2025

Adverse drug events associated with insulin glargine: a real-world pharmacovigilance study based on the FAERS database

in Experimental Pharmacology and Drug Discovery

Tongtong Wang
Gefei He
Wan Xiong
Juanjuan Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563238

4,082 views

Review

Published on 28 Apr 2025

Quercetin as a therapeutic agent for acute pancreatitis: a comprehensive review of antioxidant, anti-inflammatory, and immunomodulatory mechanisms

in Experimental Pharmacology and Drug Discovery

Zeyi Jiang
Gamar Lhamo
Mengjie Ma
Xuxia Ye
Jin Chen
Yibo He
Jian Xu
Liquan Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1587314

3,586 views
10 citations

Original Research

Published on 28 Apr 2025

The effects of ondansetron on diabetes and high-fat diet-induced liver disease: a critical role for protein tyrosine phosphatase 1B

in Experimental Pharmacology and Drug Discovery

Fawad Naeem
Maryam Aqeel
Muhammad Ammar Zahid
Mustafeez Mujtaba Babar
Fawad Ali Shah
Abdelali Agouni
Sohaib Zafar Malik

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565628

3,196 views

Original Research

Published on 28 Apr 2025

Apigenin promotes melanogenesis and melanosome transport through the c-KIT/Raf-1/MAPK/CREB pathway in HEMCs

in Experimental Pharmacology and Drug Discovery

Jinpeng Lv
Duo Meng
Huansha Zhang
Wenhui Xu
Xiaohong An
Chuanwei Yin
Kun Zou
Rongyin Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572878

4,326 views
2 citations

Original Research

Published on 25 Apr 2025

Brain-derived uroguanylin as a regulator of postprandial brown adipose tissue activation: a potential therapeutic approach for metabolic disorders

in Experimental Pharmacology and Drug Discovery

Nikola Habek
Martina Ratko
Dora Sedmak
Ivan Banovac
Vladiana Crljen
Milan Kordić
Marina Radmilović
Siniša Škokić
Martina Tkalčić
Anton Mažuranić

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569163

2,562 views

Original Research

Published on 25 Apr 2025

Assessment of potential drug-drug interactions in patients with hereditary angioedema from the ITACA cohort: simulations from a real-life dataset considering danazol versus berotralstat

in Experimental Pharmacology and Drug Discovery

Andrea Zanichelli
Dario Cattaneo
Antonio Gidaro
Riccardo Senter
Francesco Arcoleo
Pietro Accardo
Donatella Bignardi
Paolo Borrelli
Caterina Colangelo
Tiziana De Pasquale

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550133

2,919 views
1 citation

Original Research

Published on 25 Apr 2025

Prognostic significance and multivariate modeling of COL4A family genes and HMGA2 in glioma

in Experimental Pharmacology and Drug Discovery

Aijun Lu
Jiankun Zang
Na Tan
Liping Wei
Ying Liang
Zefeng Tan
Anding Xu
Dan Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591932

2,149 views

Original Research

Published on 24 Apr 2025

Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes

in Experimental Pharmacology and Drug Discovery

Jiangming Zhong
Ling Liang
Nan Zhao
Jing Wang
Peng Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562244

3,908 views
2 citations

Original Research

Published on 24 Apr 2025

Combinatorial biosynthesis of novel gentamicin derivatives with nonsense mutation readthrough activity and low cytotoxicity

in Experimental Pharmacology and Drug Discovery

Lihua Yang
Hang Zhai
Tingting Tian
Botong Liu
Xianpu Ni
Huanzhang Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575840

2,415 views
1 citation

Original Research

Published on 24 Apr 2025

Druggable proteins of Alistipes reveal promising antimicrobial targets against chronic intestinal inflammation

in Experimental Pharmacology and Drug Discovery

Saman Sohail
Ayesha Wisal
Sobia Rana
Rao Muhammad Abid Khan
Asad Ullah
Farooq-Ahmad Khan
Muhammad Irfan
Muhammad Imran
Paulo V. S. D. Carvalho
Renato Rozental

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1555062

2,958 views
5 citations

Review

Published on 24 Apr 2025

TRPV1-target drugs for the treatment of orofacial pain

in Experimental Pharmacology and Drug Discovery

Ana Cláudia Macedo Andrade
Natalia Molina Esquivel
Florencia Goldschmied Rossel
Bruna Benso

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1568109

3,760 views
2 citations

Original Research

Published on 24 Apr 2025

Integrating ensemble machine learning and multi-omics approaches to identify Dp44mT as a novel anti-Candida albicans agent targeting cellular iron homeostasis

in Experimental Pharmacology and Drug Discovery

Xiaowei Chai
Yuanying Jiang
Hui Lu
Xin Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574990

3,164 views

Original Research

Published on 23 Apr 2025

PDP1 related ferroptosis risk signature indicates distinct immune microenvironment and prognosis of breast cancer patients

in Experimental Pharmacology and Drug Discovery

Yufeng Wang
Huifen Dang
Gongjian Zhu
Yingxia Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551325

2,925 views
1 citation

Original Research

Published on 23 Apr 2025

Comprehensive characterisation of the active ingredients of Smilax glabra Roxb based on chemical fingerprinting, metabolic fingerprinting and pharmacodynamic fingerprinting

in Experimental Pharmacology and Drug Discovery

Wenqing Shi
Mengqi Jia
Xiao Li
Xin Zhao
Chenxi Wang
Guorong Fan
Yuefen Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519054

3,160 views
1 citation

Original Research

Published on 16 Apr 2025

Repurposing major metabolites of lamiaceae family as potential inhibitors of α-synuclein aggregation to alleviate neurodegenerative diseases: an in silico approach

in Experimental Pharmacology and Drug Discovery

Soham Bhattacharya
Neha Gupta
Adrish Dutta
Pijush Kanti Khanra
Ritesh Dutta
Jana Žiarovská
Nikolay T. Tzvetkov
Lucie Severová
Lenka Kopecká
Luigi Milella

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519145

2,767 views

Review

Published on 16 Apr 2025

Hepatorenal protective effects of essential oils against chemical overexposure induced oxidative damage

in Experimental Pharmacology and Drug Discovery

Faming Jiang
Xiaoyan Huang
Xingying Chen
Yuanhua Xian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580805

2,197 views

Original Research

Published on 16 Apr 2025

The development of a high-throughput acoustic droplet ejection mass-spectrometry assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of SLC1-A3, -A2 and -A1 in a drug discovery program

in Experimental Pharmacology and Drug Discovery

Yasmin Zuschlag
Antje Pommereau
Jennifer Warkentin
Thomas Licher
Felix Bärenz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544682

2,699 views

Original Research

Published on 15 Apr 2025

YX-112, a novel celastrol-derived PROTAC, inhibits the development of triple-negative breast cancer by targeting the degradation of multiple proteins

in Experimental Pharmacology and Drug Discovery

Yongxue Gu
Mengmeng Yang
Wenbin Wang
Lihua Li
Ying Ma
Wenshan Liu
Qiang Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571135

3,242 views
2 citations

Perspective

Published on 15 Apr 2025

Metabolic anomalies in vitiligo: a new frontier for drug repurposing strategies

in Experimental Pharmacology and Drug Discovery

Alessia Paganelli
Federica Papaccio
Mauro Picardo
Barbara Bellei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546836

4,772 views
3 citations

Original Research

Published on 14 Apr 2025

Integrating traditional omics and machine learning approaches to identify microbial biomarkers and therapeutic targets in pediatric inflammatory bowel disease

in Experimental Pharmacology and Drug Discovery

Lanlan Li
XuZai Deng
Shuge Wang
Tao Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545392

2,180 views
2 citations

Original Research

Published on 11 Apr 2025

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

in Experimental Pharmacology and Drug Discovery

Bin Liao
Pan Wang
Sheng Gong
Lu Zhao
Jie Liu
Nan Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575332

2,471 views
1 citation

Original Research

Published on 09 Apr 2025

Danggui Shaoyao San ameliorates Alzheimer’s disease by regulating lipid metabolism and inhibiting neuronal ferroptosis through the AMPK/Sp1/ACSL4 signaling pathway

in Experimental Pharmacology and Drug Discovery

Kai Gong
Shuang Zhou
Li Xiao
Mengzhen Xu
Yuhe Zhou
Kaihui Lu
Xin Yu
Jiang Zhu
Chuanguo Liu
Qingjun Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588375

3,405 views
3 citations

Review

Published on 09 Apr 2025

Regulation of pyroptosis by natural products in ulcerative colitis: mechanisms and therapeutic potential

in Experimental Pharmacology and Drug Discovery

Xiaobei Lu
Yapeng Sun
Zhaoyi Zhang
Zhigang Sun
Shaohui Wang
Erping Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573684

3,992 views
3 citations

3,845 articles

articles

Irisin attenuates cardiac injury and improves prognosis in rats with hemorrhagic shock by maintaining mitochondrial homeostasis via the AMPK/Drp1 pathway

Adverse drug events associated with insulin glargine: a real-world pharmacovigilance study based on the FAERS database

Quercetin as a therapeutic agent for acute pancreatitis: a comprehensive review of antioxidant, anti-inflammatory, and immunomodulatory mechanisms

The effects of ondansetron on diabetes and high-fat diet-induced liver disease: a critical role for protein tyrosine phosphatase 1B

Apigenin promotes melanogenesis and melanosome transport through the c-KIT/Raf-1/MAPK/CREB pathway in HEMCs

Brain-derived uroguanylin as a regulator of postprandial brown adipose tissue activation: a potential therapeutic approach for metabolic disorders

Assessment of potential drug-drug interactions in patients with hereditary angioedema from the ITACA cohort: simulations from a real-life dataset considering danazol versus berotralstat

Prognostic significance and multivariate modeling of COL4A family genes and HMGA2 in glioma

Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes

Combinatorial biosynthesis of novel gentamicin derivatives with nonsense mutation readthrough activity and low cytotoxicity

Druggable proteins of Alistipes reveal promising antimicrobial targets against chronic intestinal inflammation

TRPV1-target drugs for the treatment of orofacial pain

Integrating ensemble machine learning and multi-omics approaches to identify Dp44mT as a novel anti-Candida albicans agent targeting cellular iron homeostasis

PDP1 related ferroptosis risk signature indicates distinct immune microenvironment and prognosis of breast cancer patients

Comprehensive characterisation of the active ingredients of Smilax glabra Roxb based on chemical fingerprinting, metabolic fingerprinting and pharmacodynamic fingerprinting

Repurposing major metabolites of lamiaceae family as potential inhibitors of α-synuclein aggregation to alleviate neurodegenerative diseases: an in silico approach

Hepatorenal protective effects of essential oils against chemical overexposure induced oxidative damage

The development of a high-throughput acoustic droplet ejection mass-spectrometry assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of SLC1-A3, -A2 and -A1 in a drug discovery program

YX-112, a novel celastrol-derived PROTAC, inhibits the development of triple-negative breast cancer by targeting the degradation of multiple proteins

Metabolic anomalies in vitiligo: a new frontier for drug repurposing strategies

Integrating traditional omics and machine learning approaches to identify microbial biomarkers and therapeutic targets in pediatric inflammatory bowel disease

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

Danggui Shaoyao San ameliorates Alzheimer’s disease by regulating lipid metabolism and inhibiting neuronal ferroptosis through the AMPK/Sp1/ACSL4 signaling pathway

Regulation of pyroptosis by natural products in ulcerative colitis: mechanisms and therapeutic potential