Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Accepted on 23 Apr 2025

Reduced Abundance of Fusobacterium Signifies Cardiovascular Benefits of Sodium Glucose Cotransporter 2 Inhibitor in Type 2 Diabetes: A Single Arm Clinical Trial

in Experimental Pharmacology and Drug Discovery

Shuhui Yang
Deng Jiankun
Xiaoxu Weng
Zhaojie Ma
Nie Lin
Yili Xiao
Rui Zuo
Yufei Hu
Canbin Zheng
Xiaoshan Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600464

Original Research

Accepted on 23 Apr 2025

No significant gender differences in driving-related skills of alcohol mixed with energy drinks in an experimental binge drinking episode

in Experimental Pharmacology and Drug Discovery

Olga Hladun
Esther Papaseit Fontanet
Lourdes Poyatos
Soraya Martín
Ana Pilar Pérez- Acevedo
Ana María Barriocanal
Tatiana Bustos-Cardona
Susana Malumbres
Rafael De La Torre
Klaus Langohr

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581229

Original Research

Accepted on 23 Apr 2025

Therapeutic Effects and Mechanisms of Fufang Longdan Mixture on Metabolic Syndrome with Psoriasis via miR-29a-5p/IGF-1R Axis

in Experimental Pharmacology and Drug Discovery

Guangyun LUO
Xiangyi KONG
Fang WANG
Zhiming WANG
Zhuo ZHANG
Huan CUI
Yiwen ZHANG
Wen HUANG
Xuesong YANG
Jianzhou YE

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585369

Original Research

Published on 23 Apr 2025

PDP1 related ferroptosis risk signature indicates distinct immune microenvironment and prognosis of breast cancer patients

in Experimental Pharmacology and Drug Discovery

Yufeng Wang
Huifen Dang
Gongjian Zhu
Yingxia Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551325

Original Research

Published on 23 Apr 2025

Comprehensive characterisation of the active ingredients of Smilax glabra Roxb based on chemical fingerprinting, metabolic fingerprinting and pharmacodynamic fingerprinting

in Experimental Pharmacology and Drug Discovery

Wenqing Shi
Mengqi Jia
Xiao Li
Xin Zhao
Chenxi Wang
Guorong Fan
Yuefen Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519054

Original Research

Accepted on 22 Apr 2025

Synthesis, target analysis, and cerebroprotective effects of novel imide antioxidants via the Nrf2/HO-1 pathway in cerebral ischemia-reperfusion injury

in Experimental Pharmacology and Drug Discovery

Lili Hung
Yingqi Chen
Hua Zhou
Huihui Chen
Wu Xiping
Zhuochao Wu
Zhoudi Liu
Zhiwei Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552717

Original Research

Accepted on 22 Apr 2025

Repurposing of small molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung

in Experimental Pharmacology and Drug Discovery

Maria Jordan
Kevin Schmidt
Maximilian Fuchs
Annette Just
Angelika Pfanne
Lena Willmer
Lavinia Neubert
Christopher Werlein
Patrick Zardo
Andreas Pich

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534989

Review

Accepted on 21 Apr 2025

Advancing Precision Oncology with AI-Powered Genomic Analysis

in Experimental Pharmacology and Drug Discovery

Ruby Srivastava

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591696

Original Research

Accepted on 21 Apr 2025

Investigation of Fructus sophorae extract's Therapeutic Mechanism in Atrophic Vaginitis Based on Network Pharmacology and Experimental Validation

in Experimental Pharmacology and Drug Discovery

Jiarui Zheng
Weiming Wang
Wenting Song
Yehao Zhang
Mingjiang Yao
Guangrui Wang
Zishan Huang
Feng Li
Ren Jun Guo
Li Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571976

Review

Accepted on 21 Apr 2025

Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV

in Experimental Pharmacology and Drug Discovery

Zhongsong Zhang
Run Tan
Long Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562845

Original Research

Accepted on 21 Apr 2025

Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation

in Experimental Pharmacology and Drug Discovery

Yixiao Yan
Mingzhen Fang
Cong Zhao
Xinru Lin
Chen Tong
Cheng Xiang
Ya Ran
Xuelian Wang
Shuixin Li
Lili Fu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542296

Original Research

Accepted on 21 Apr 2025

Probiotic biofilm modified bioceramics for bone defect healing via osteogenesis, angiogenesis, and immune modulation

in Experimental Pharmacology and Drug Discovery

Junwei Su
Huiyun Gu
Xiang Huang
YING YUAN
Yunchang Zhao
Fan Yang
Yong Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588023

Review

Accepted on 21 Apr 2025

Quercetin as a Therapeutic Agent for Acute Pancreatitis: A Comprehensive Review of Antioxidant, Anti-inflammatory, and Immunomodulatory Mechanisms

in Experimental Pharmacology and Drug Discovery

Zeyi Jiang
Gamar Lhamo
Mengjie Ma
Xuxia Ye
Jin Chen
Yibo He
Jian Xu
Liquan Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1587314

Original Research

Accepted on 18 Apr 2025

Compatibility optimization of the traditional Chinese medicines 'Eczema mixture' based on Back-Propagation Artificial Neural Network and Non-dominated Sorting Genetic Algorithm

in Experimental Pharmacology and Drug Discovery

Xin He
Zhijie Song
Yanqun Yang
Siqi Wu
Shuo Meng
Huanyu E
Hong Fei Li
Guoyu Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593783

326 views

Original Research

Accepted on 18 Apr 2025

Adverse drug events associated with Insulin glargine: a real-world pharmacovigilance study based on the FAERS database

in Experimental Pharmacology and Drug Discovery

Wang Tongtong
Gefei He
Wan Xiong
Huang Juanjuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563238

101 views

Review

Accepted on 18 Apr 2025

The research progress on radionuclides in osteoporosis diagnosis and drug efficacy monitoring

in Experimental Pharmacology and Drug Discovery

Jie FU
Chi Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594903