Original Research

Published on 21 Nov 2024

Evaluation of the inhibitory mechanism of Pennisetum glaucum (pearl millet) bioactive compounds for rheumatoid arthritis: an in vitro and computational approach

in Experimental Pharmacology and Drug Discovery

Maria Sharif
Peter John
Attya Bhatti
Rehan Zafar Paracha
Abid Majeed

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488790

166 views

Original Research

Published on 20 Nov 2024

Exploring somatic mutations in BRAF, KRAS, and NRAS as therapeutic targets in Saudi colorectal cancer patients through massive parallel sequencing and variant classification

in Experimental Pharmacology and Drug Discovery

Thamer Abdulhamid Aljuhani
Noor Ahmad Shaik
Rahaf Talal Alqawas
Rana Y. Bokhary
Mahmood Al-Mutadares
Hadiah Bassam Al Mahdi
Nuha Al-Rayes
Ashraf AbdulRahman El-Harouni
Ramu Elango
Babajan Banaganapalli

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1498295

105 views

Original Research

Accepted on 19 Nov 2024

6-Hydroxyflavanone Treats Anxiety and Chemotherapy-Induced Neuropathy in Sprague Dawley Rats

in Experimental Pharmacology and Drug Discovery

Dr Shehla Akbar
Shehla Akbar
Fazal Subhan
Rida Qamar
Aroosha Akbar
Naila Shahbaz
Muhammad Amir
Nayyer Saddique
Salman Ul Islam

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486918

Systematic Review

Accepted on 19 Nov 2024

Effect of Icariin on Ovarian Cancer: A Combined Network Pharmacology and Meta-Analysis of In Vitro Studies Approach

in Experimental Pharmacology and Drug Discovery

Shang-mei Cao
Bo-lin Chen
Zhen-zhen Zou
Shao-zhe Yang
Xiuhong Fu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1418111

Original Research

Accepted on 18 Nov 2024

Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats

in Experimental Pharmacology and Drug Discovery

Xing Wang
Dongmei Long
Jiaxuan Li
Maoting Zhou
Xianghong Hu
Yu Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1506398

Original Research

Accepted on 18 Nov 2024

Clinical predictors of treatment response to gabapentin in women with unexplained chronic pelvic pain?

in Experimental Pharmacology and Drug Discovery

Lydia Coxon
Maryam Amer
Jane Daniels
Ann M Doust
Scott C Mackenzie
Andrew Horne
Katy Vincent

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1460206

Original Research

Accepted on 18 Nov 2024

Combining Acmella Oleracea and Boswellia Serrata extracts: a novel pharmacological approach in inflammatory vestibulodynia

in Experimental Pharmacology and Drug Discovery

Antimo Fusco
Michela Perrone
Federica Ricciardi
Andrea Maria Morace
Roozbe Bonsale
Milena Melake Teweldemedhin
Emanuele Di Martino
Rebecca Limongelli
Alfonso Papa
Sabatino Maione

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1508107

Original Research

Accepted on 18 Nov 2024

In Vitro Hair Growth-Promoting Effects of Araliadiol via p38/PPARγ Signaling Pathway in Human Hair Follicle Stem and Human Dermal Papilla Cells

in Experimental Pharmacology and Drug Discovery

Seokmuk Park
Han Woong Park
Dae Bang Seo
Dae Sung Yoo
Seunghee Bae

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1482898

Systematic Review

Published on 18 Nov 2024

Efficacy and safety of Epimedium total flavonoids for primary osteoporosis: a systematic review and meta-analysis

in Experimental Pharmacology and Drug Discovery

Jinkun Li
Xudong Huang
Yifeng Yuan
Haixin Zhang
Hang Zhou
Wei Xiong
Yuyi Li
Zechen Zhang
Fengqing Qie
Yingdelong Mao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505926

157 views

Original Research

Published on 18 Nov 2024

Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers

in Experimental Pharmacology and Drug Discovery

Chenxi Wang
Xin Zhao
Jingjing Jiang
Mengqi Jia
Wenqing Shi
Zhenghua Wu
Shiyu Feng
Guorong Fan
Yuefen Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1481091

259 views

Original Research

Accepted on 15 Nov 2024

Discovery of novel PARP1/NRP1 dual-targeting inhibitors with strong antitumor potency

in Experimental Pharmacology and Drug Discovery

Juanjuan Liu
Yifei Geng
Su Jiang
Lixia Guan
Junyi Gao
Miao-Miao Niu
Jindong Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1454957

Editorial

Accepted on 15 Nov 2024

Editorial: What does Experimental Pharmacology and Drug discovery look like in 2035?

in Experimental Pharmacology and Drug Discovery

Maria Serena Fabbrini
Riccardo Vago

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1504817

Original Research

Published on 15 Nov 2024

Discovery of novel and highly potent dual-targeting PKMYT1/HDAC2 inhibitors for hepatocellular carcinoma through structure-based virtual screening and biological evaluation

in Experimental Pharmacology and Drug Discovery

Yang Yang
Yuting Wang
Jing Chen
Miao-Miao Niu
Yongbin Wang
Xing Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1491497

197 views

Mini Review

Accepted on 14 Nov 2024

Revealing Secrets of Blue Zones

in Experimental Pharmacology and Drug Discovery

Nuray Nuriye Ulusu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1428111

115 views

Original Research

Published on 14 Nov 2024

Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions

in Experimental Pharmacology and Drug Discovery

Mohammed Alrouji
Kumar Venkatesan
Mohammed S. Alshammari
Fahad A. Alhumaydhi
Sheeba Shafi
Sharaf E. Sharaf
Moyad Shahwan
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488585

293 views

Original Research

Accepted on 13 Nov 2024

Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota

in Experimental Pharmacology and Drug Discovery

Xin Yang
Canhui Hong
Tangfei Guan
ChengGui Zhang
Pei Yun Xiao
Yongshou Yang
Huai Xiao
Zhengchun He

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1429960

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Articles

Evaluation of the inhibitory mechanism of Pennisetum glaucum (pearl millet) bioactive compounds for rheumatoid arthritis: an in vitro and computational approach

Exploring somatic mutations in BRAF, KRAS, and NRAS as therapeutic targets in Saudi colorectal cancer patients through massive parallel sequencing and variant classification

6-Hydroxyflavanone Treats Anxiety and Chemotherapy-Induced Neuropathy in Sprague Dawley Rats

Effect of Icariin on Ovarian Cancer: A Combined Network Pharmacology and Meta-Analysis of In Vitro Studies Approach

Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats

Clinical predictors of treatment response to gabapentin in women with unexplained chronic pelvic pain?

Combining Acmella Oleracea and Boswellia Serrata extracts: a novel pharmacological approach in inflammatory vestibulodynia

In Vitro Hair Growth-Promoting Effects of Araliadiol via p38/PPARγ Signaling Pathway in Human Hair Follicle Stem and Human Dermal Papilla Cells

Efficacy and safety of Epimedium total flavonoids for primary osteoporosis: a systematic review and meta-analysis

Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers

Discovery of novel PARP1/NRP1 dual-targeting inhibitors with strong antitumor potency

Editorial: What does Experimental Pharmacology and Drug discovery look like in 2035?

Discovery of novel and highly potent dual-targeting PKMYT1/HDAC2 inhibitors for hepatocellular carcinoma through structure-based virtual screening and biological evaluation

Revealing Secrets of Blue Zones

Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions

Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota