Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 27 Jan 2025

A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma

in Experimental Pharmacology and Drug Discovery

Shihao Li
Lina Zhang
Haiyang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1532610

Original Research

Accepted on 24 Jan 2025

Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM

in Experimental Pharmacology and Drug Discovery

Xiaofeng Zhou
Zhifang Liu
Weixiong Zhang
Lin Dai
Tao Chen
Zexiong Lin
Henry Wei
Qi Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1530268

Original Research

Published on 24 Jan 2025

Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head necrosis

in Experimental Pharmacology and Drug Discovery

Manting Liu
Jiexiang Ye
Runtian Wu
Dongqiang Luo
Tao Huang
Dandan Dai
Kexin Wang
Yanping Du
Junwen Ou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1506594

183 views

Review

Accepted on 23 Jan 2025

OPTIMIZING THERAPEUTIC OUTCOMES: PRECONDITIONING STRATEGIES FOR MSC-DERIVED EXTRACELLULAR VESICLES

in Experimental Pharmacology and Drug Discovery

Yuqi Song
Weikun Tian
Fengrui Liang
Erin Rayhill
Liping Ye
Xinghan Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1509418

Original Research

Accepted on 23 Jan 2025

COL7A1 indicates crucial potential as a basal membrane-related prognostic biomarker and therapeutic target in lung adenocarcinoma

in Experimental Pharmacology and Drug Discovery

Jiao Zhang
Rui Zi
Zongying Jiang
Ping Hu
Haixia Zhang
Yanjiao Zhao
Yan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543193

Original Research

Published on 23 Jan 2025

hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways

in Experimental Pharmacology and Drug Discovery

Yan Yu
Chengchun Zhu
Xiao Wang
Ying Shi
Yiping Gao
Zhiyi Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545300

190 views

Original Research

Published on 23 Jan 2025

Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties

in Experimental Pharmacology and Drug Discovery

Jan Šťastný
Ángela Morellá-Aucejo
Tomáš Skala
Andrea Bernardos
Petr Maršík
Araceli Lérida-Viso
Jaroslav Matějka
Anna Mascellani Bergo
María Dolores Marcos
Ramón Martínez-Máñez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526502

168 views

Review

Published on 23 Jan 2025

A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms

in Experimental Pharmacology and Drug Discovery

Yuan Yan
Yiyao Wu
Yu Zhao
Yaguang Yang
Guangtao An
Zhidong Liu
Dongli Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1513406

232 views

Review

Accepted on 22 Jan 2025

New Strategies to Enhance the Efficiency and Precision of Drug Discovery

in Experimental Pharmacology and Drug Discovery

Yalan Tu
Qi An
Liang Huang
Chuan Wang
Dongmei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550158

Original Research

Accepted on 22 Jan 2025

Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats: Relevance to its antioxidative effects

in Experimental Pharmacology and Drug Discovery

Yasaman Ahmadpour
Gholamreza Bahrami
Elham Arkan
Fatemeh Abbaszadeh
Faranak Aghaz
Sajad Fakhri
Javier Echeverria

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533025

Original Research

Accepted on 21 Jan 2025

Melatonin protects retinal pigment epithelium cells against ferroptosis in AMD via the PI3K/AKT/MDM2/P53 pathway

in Experimental Pharmacology and Drug Discovery

Ping Wu
Long Zhao
Yong Du
Jing Lu
Yuxia He
Qinxin Shu
Hui Peng
Xing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543575

Original Research

Accepted on 21 Jan 2025

Brigatinib can inhibit proliferation and induce apoptosis of human immortalized keratinocyte cells

in Experimental Pharmacology and Drug Discovery

Qi Yang
Dan Zhao
Lin jie Ju
Peng Cao
Ji-Fu Wei
Zhixian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524277

Editorial

Published on 21 Jan 2025

Editorial: Methods in experimental pharmacology 2023

in Experimental Pharmacology and Drug Discovery

Somasundaram Arumugam
Amit Khurana
Kala Kumar Bharani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531464

183 views

Original Research

Published on 21 Jan 2025

A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity

in Experimental Pharmacology and Drug Discovery

Wen Wang
Meiting Wang
Huanbai Wang
Weifeng Xu
Conggang Wang
Jie Pei
Xiaodan Li
Dongting Zhangsun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466504

229 views

Original Research

Published on 21 Jan 2025

Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments

in Experimental Pharmacology and Drug Discovery

Bowen Yin
Jingyi Ren
Xuanyi Liu
Yadong Zhang
Jinshi Zuo
Rui Wen
Huanting Pei
Miaomiao Lu
Siqi Zhu
Zhenao Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524448

248 views

Original Research

Accepted on 20 Jan 2025

Deciphering the Role of Wnt/β-Catenin and miR-214 in Knee Osteoarthritis: Molecular and Clinical Insights

in Experimental Pharmacology and Drug Discovery

waad A Samman
Esraa M. Mosalam
Dalia S. Saif
Mahmoud S. Abdallah
Abdel-Aziz Awad Zidan
Amany Said Sallam
Shimaa Abdelsattar
Fatma Khalil
Amany E. Elashkar
Somia Mokabel Mohamed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507693

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Articles

A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma

Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM

Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head necrosis

OPTIMIZING THERAPEUTIC OUTCOMES: PRECONDITIONING STRATEGIES FOR MSC-DERIVED EXTRACELLULAR VESICLES

COL7A1 indicates crucial potential as a basal membrane-related prognostic biomarker and therapeutic target in lung adenocarcinoma

hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways

Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties

A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms

New Strategies to Enhance the Efficiency and Precision of Drug Discovery

Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats: Relevance to its antioxidative effects

Melatonin protects retinal pigment epithelium cells against ferroptosis in AMD via the PI3K/AKT/MDM2/P53 pathway

Brigatinib can inhibit proliferation and induce apoptosis of human immortalized keratinocyte cells

Editorial: Methods in experimental pharmacology 2023

A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity

Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments

Deciphering the Role of Wnt/β-Catenin and miR-214 in Knee Osteoarthritis: Molecular and Clinical Insights