Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 11 Mar 2024

Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology

in Drug Metabolism and Transport

Ning Tang
Yan Wang
Jiarui Miao
Yang Zhao
Yue Cao
Wentao Sun
Jingke Zhang
Hua Sui
Bing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1363415

2,469 views
1 citation

Original Research

Published on 04 Mar 2024

Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors

in Drug Metabolism and Transport

Xiaoqing Li
Yunhai Bo
Qingping Zeng
Lei Diao
Stephanie Greene
John Patterson
Lu Liu
Fen Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1322557

1,565 views
3 citations

Original Research

Published on 04 Mar 2024

Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach

in Drug Metabolism and Transport

Feng Liang
Yimei Zhang
Qian Xue
Na Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1363259

1,331 views

Original Research

Published on 01 Mar 2024

Optimization and preparation of a compound cod liver oil film former agent: an orthogonal design

in Drug Metabolism and Transport

Yao He
Ying Zhang
Zheng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1296448

1,392 views

Review

Published on 20 Feb 2024

A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis

in Drug Metabolism and Transport

Nour Ayoub
Antoine Gedeon
Hélène Munier-Lehmann

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1329011

3,930 views
2 citations

Original Research

Published on 20 Feb 2024

Ivacaftor pharmacokinetics and lymphatic transport after enteral administration in rats

in Drug Metabolism and Transport

Jiří Pozniak
Pavel Ryšánek
David Smrčka
Petr Kozlík
Tomáš Křížek
Jaroslava Šmardová
Anežka Nováková
Debanjan Das
Daniel Bobek
Mahak Arora

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1331637

1,727 views
1 citation

Original Research

Published on 08 Feb 2024

Herb-drug interactions of silybinin and cilofexor in beagle dogs based on pharmacokinetics by UPLC-MS/MS

in Drug Metabolism and Transport

Xinyi Wei
Yanding Su
Qian Cheng
Songmao Liang
Tingping Zhang
Lengxin Duan
Xiuwei Shen
Xiangjun Qiu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1334402

1,169 views

Original Research

Published on 26 Jan 2024

Exploration of biomarkers for efficacy evaluation of traditional Chinese medicine syndromes of acute exacerbation of chronic obstructive pulmonary disease based on metabolomics

in Drug Metabolism and Transport

Zhang Hailong
Si Yimei
Du Yan
Liu Xinguang
Li Jiansheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1302950

2,777 views
1 citation

Clinical Trial

Published on 26 Jan 2024

Pharmacokinetics, pharmacodynamics and safety of 15 mg-tolvaptan administered orally for 7 consecutive days to Chinese patients with child-Pugh B cirrhosis

in Drug Metabolism and Transport

Hongzhong Liu
Yongfeng Wang
Tao Liu
Yingxuan Chen
Xin Zheng
Ming Liu
Qian Zhao
Minde Zeng
Ji Jiang
Yimin Mao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1324299

1,727 views

Editorial

Published on 25 Jan 2024

Editorial: Drug metabolism-induced organ toxicity

in Drug Metabolism and Transport

Adnan A. Kadi
Yang Li
Abhinav Parashar
Mohamed W. Attwa

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1362229

1,624 views

Review

Published on 16 Jan 2024

Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing

in Drug Metabolism and Transport

Lin Zhao
Jiamei Chen
Bai Bai
Guili Song
Jingwen Zhang
Han Yu
Shiwei Huang
Zhang Wang
Guanghua Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1333986

10,353 views
6 citations

Original Research

Published on 10 Jan 2024

Pharmacokinetics of recombinant human annexin A5 (SY-005) in patients with severe COVID-19

in Drug Metabolism and Transport

Brent J. Tschirhart
Xiangru Lu
Aristide Laurel Mokale Kognou
Claudio M. Martin
Marat Slessarev
Douglas D. Fraser
Aleksandra Leligdowicz
Bradley Urquhart
Qingping Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1299613

1,584 views
3 citations

Clinical Trial

Published on 09 Jan 2024

Pharmacokinetics, metabolite profiling, safety and tolerability of YZJ-4729 tartrate, a novel G protein-biased μ-opioid receptor agonist, in healthy Chinese subjects

in Drug Metabolism and Transport

Yufeng Ni
Huaye Gao
Wen Ouyang
Guoping Yang
Minlu Cheng
Li Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1295319

1,577 views
1 citation

Original Research

Published on 04 Jan 2024

Enhancing voriconazole therapy in liver dysfunction: exploring administration schemes and predictive factors for trough concentration and efficacy

in Drug Metabolism and Transport

Yichang Zhao
Huaiyuan Liu
Chenlin Xiao
Jingjing Hou
Bikui Zhang
Jiakai Li
Min Zhang
Yongfang Jiang
Indy Sandaradura
Xuansheng Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1323755

1,526 views
2 citations

Clinical Trial

Published on 22 Dec 2023

Evaluating the bioequivalence and safety of liraglutide injection versus Victoza® in healthy Chinese subjects: a randomized, open, two-cycle, self-crossover phase I clinical trial

in Drug Metabolism and Transport

Chao Liu
Hongrong Xu
Fei Yuan
Hanjing Chen
Lei Sheng
Weili Chen
Haisong Xie
Hongmei Xu
Xuening Li

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1326865

3,894 views

Clinical Trial

Published on 21 Dec 2023

Evaluation of NTP42, a novel thromboxane receptor antagonist, in a first-in-human phase I clinical trial

in Drug Metabolism and Transport

Helen M. Reid
Mark Maginn
C. Michael Perkins
Eamon P. Mulvaney
Malcolm Boyce
Takahiro Yamamoto
B. Therese Kinsella

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1296188

2,449 views
1 citation

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Articles

Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology

Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors

Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach

Optimization and preparation of a compound cod liver oil film former agent: an orthogonal design

A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis

Ivacaftor pharmacokinetics and lymphatic transport after enteral administration in rats

Herb-drug interactions of silybinin and cilofexor in beagle dogs based on pharmacokinetics by UPLC-MS/MS

Exploration of biomarkers for efficacy evaluation of traditional Chinese medicine syndromes of acute exacerbation of chronic obstructive pulmonary disease based on metabolomics

Pharmacokinetics, pharmacodynamics and safety of 15 mg-tolvaptan administered orally for 7 consecutive days to Chinese patients with child-Pugh B cirrhosis

Editorial: Drug metabolism-induced organ toxicity

Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing

Pharmacokinetics of recombinant human annexin A5 (SY-005) in patients with severe COVID-19

Pharmacokinetics, metabolite profiling, safety and tolerability of YZJ-4729 tartrate, a novel G protein-biased μ-opioid receptor agonist, in healthy Chinese subjects

Enhancing voriconazole therapy in liver dysfunction: exploring administration schemes and predictive factors for trough concentration and efficacy

Evaluating the bioequivalence and safety of liraglutide injection versus Victoza® in healthy Chinese subjects: a randomized, open, two-cycle, self-crossover phase I clinical trial

Evaluation of NTP42, a novel thromboxane receptor antagonist, in a first-in-human phase I clinical trial