Original Research

Published on 02 May 2024

Physiologically based pharmacokinetic modeling to predict the pharmacokinetics of codeine in different CYP2D6 phenotypes

in Drug Metabolism and Transport

Yujie Yang
Xiqian Zhang
Yirong Wang
Heng Xi
Min Xu
Liang Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1342515

1,621 views

Original Research

Published on 29 Apr 2024

The first selective VAP-1 inhibitor in China, TT-01025-CL: safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses

in Drug Metabolism and Transport

Yuanxun Yang
Lei Yu
Zejuan Sheng
Hui Lin
Zuyi Weng
Wei Song
Bei Cao
Yu Zhao
Yingsheng Gao
Shumao Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1327008

1,317 views

Original Research

Published on 29 Apr 2024

In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin

in Drug Metabolism and Transport

Jan Thomann
Karolina E. Kolaczynska
Oliver V. Stoeckmann
Deborah Rudin
Patrick Vizeli
Marius C. Hoener
Christopher R. Pryce
Franz X. Vollenweider
Matthias E. Liechti
Urs Duthaler

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1391689

8,500 views
4 citations

Original Research

Published on 29 Apr 2024

The impacts of natural product miltirone and the CYP2D6 pharmacogenetic phenotype on fluoxetine metabolism

in Drug Metabolism and Transport

Xiaodan Zhang
Qingqing Li
Xinwu Ye
Qing Chen
Chen Chen
Guoxin Hu
Likang Zhang
Lianguo Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1373048

941 views

Original Research

Published on 19 Apr 2024

Investigation of the hypoglycemic mechanism of the ShenQi compound formula through metabonomics and 16S rRNA sequencing

in Drug Metabolism and Transport

Juan Gao
Xiujuan Zhou
Hong Gao
Guiping Xu
Chunguang Xie
Hongyan Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1349244

1,283 views

Original Research

Published on 09 Apr 2024

Iodine-induced synthetic method and pharmacokinetic study of cis- and trans-crocetin

in Drug Metabolism and Transport

Boshen Li
Yuxuan Zhang
Zhiqiang Yang
Xiaolin Li
Jun Yang
Kai Luo
Renjie Wang
Chengrong Xiao
Maoxing Li
Yue Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1364286

993 views
1 citation

Original Research

Published on 08 Apr 2024

Effect of P. corylifolia on the pharmacokinetic profile of tofacitinib and the underlying mechanism

in Drug Metabolism and Transport

Yu Wang
Quan Zhou
Huihui Wang
Wei Song
Jianfeng Wang
Abdullah Al Mamun
Peiwu Geng
Yunfang Zhou
Shuanghu Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1351882

1,006 views

Clinical Trial

Published on 04 Apr 2024

Assessment of omeprazole and famotidine effects on the pharmacokinetics of tacrolimus in patients following kidney transplant–randomized controlled trial

in Drug Metabolism and Transport

Miłosz Miedziaszczyk
Marek Karczewski
Tomasz Grabowski
Anna Wolc
Ilona Idasiak-Piechocka

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1352323

1,981 views
1 citation

Original Research

Published on 02 Apr 2024

Pharmacokinetics of desflurane uptake and disposition in piglets

in Drug Metabolism and Transport

Chih-Cherng Lu
Shung-Tai Ho
Oliver Yao-Pu Hu
Cheng-Huei Hsiong
Yuan-Chen Cheng
Che-Hao Hsu
Tso-Chou Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1339690

3,446 views

Original Research

Published on 27 Mar 2024

Clinical and pharmacological factors influencing serum clozapine and norclozapine levels

in Drug Metabolism and Transport

Anna Mach
Anna Wnorowska
Marcin Siwek
Marcin Wojnar
Maria Radziwoń-Zaleska

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1356813

1,532 views

Original Research

Published on 25 Mar 2024

Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

in Drug Metabolism and Transport

Heechun Kwak
Min-Soo Kim
Suyong Kim
Jiyoung Kim
Yasunori Aoki
Suk-Jae Chung
Hyun-Ja Nam
Wooin Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1352842

1,521 views

Original Research

Published on 18 Mar 2024

Application of machine learning combined with population pharmacokinetics to improve individual prediction of vancomycin clearance in simulated adult patients

in Drug Metabolism and Transport

Guodong Li
Yubo Sun
Liping Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1352113

1,469 views
1 citation

Mini Review

Published on 13 Mar 2024

Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine

in Drug Metabolism and Transport

Winnie S. Liang
Brett Beaulieu-Jones
Susan Smalley
Michael Snyder
Laura H. Goetz
Nicholas J. Schork

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1348112

4,471 views
6 citations

Original Research

Published on 11 Mar 2024

Establishment of a pharmacokinetics and pharmacodynamics model of Schisandra lignans against hippocampal neurotransmitters in AD rats based on microdi-alysis liquid chromatography-mass spectrometry

in Drug Metabolism and Transport

Jinpeng Zhang
Xinyuan Cui
Shuo Zhao
Zenghui Chang
Junshuo Zhang
Yufeng Chen
Jiale Liu
Guohao Sun
Yiyuan Wang
Yuanyuan Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1342121

1,184 views
1 citation

Original Research

Published on 11 Mar 2024

Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology

in Drug Metabolism and Transport

Ning Tang
Yan Wang
Jiarui Miao
Yang Zhao
Yue Cao
Wentao Sun
Jingke Zhang
Hua Sui
Bing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1363415

2,236 views
1 citation

Original Research

Published on 04 Mar 2024

Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors

in Drug Metabolism and Transport

Xiaoqing Li
Yunhai Bo
Qingping Zeng
Lei Diao
Stephanie Greene
John Patterson
Lu Liu
Fen Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1322557

1,504 views
3 citations

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Articles

Physiologically based pharmacokinetic modeling to predict the pharmacokinetics of codeine in different CYP2D6 phenotypes

The first selective VAP-1 inhibitor in China, TT-01025-CL: safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses

In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin

The impacts of natural product miltirone and the CYP2D6 pharmacogenetic phenotype on fluoxetine metabolism

Investigation of the hypoglycemic mechanism of the ShenQi compound formula through metabonomics and 16S rRNA sequencing

Iodine-induced synthetic method and pharmacokinetic study of cis- and trans-crocetin

Effect of P. corylifolia on the pharmacokinetic profile of tofacitinib and the underlying mechanism

Assessment of omeprazole and famotidine effects on the pharmacokinetics of tacrolimus in patients following kidney transplant–randomized controlled trial

Pharmacokinetics of desflurane uptake and disposition in piglets

Clinical and pharmacological factors influencing serum clozapine and norclozapine levels

Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

Application of machine learning combined with population pharmacokinetics to improve individual prediction of vancomycin clearance in simulated adult patients

Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine

Establishment of a pharmacokinetics and pharmacodynamics model of Schisandra lignans against hippocampal neurotransmitters in AD rats based on microdi-alysis liquid chromatography-mass spectrometry

Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology

Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors