Original Research

Published on 21 Aug 2024

The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity

in Drug Metabolism and Transport

Godefridus J. Peters
Ietje Kathmann
Elisa Giovannetti
Kees Smid
Yehuda G. Assaraf
Gerrit Jansen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1450418

1,260 views

Original Research

Published on 20 Aug 2024

Effects of three flavonoids on the metabolism of lenvatinib

in Drug Metabolism and Transport

Jinzhao Yang
Jie Chen
Qingqing Li
Ren-ai Xu
Xiaohai Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1438259

767 views

Original Research

Published on 20 Aug 2024

Influence of C-reactive protein on the pharmacokinetics of voriconazole in relation to the CYP2C19 genotype: a population pharmacokinetics analysis

in Drug Metabolism and Transport

Jing Ling
Xuping Yang
Lulu Dong
Yan Jiang
Sulan Zou
Nan Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1455721

789 views

Original Research

Published on 16 Aug 2024

A simple HPLC–MS/MS method for the determination of polymyxin B in human plasma and its application in the pharmacokinetic study in elderly patients infected with multidrug-resistant Gram-negative bacteria

in Drug Metabolism and Transport

Sheng Hu
Nan Guo
Juan Zeng
Yue Li
Yahui Zhang
Jinjiao Jiang
Bing Leng
Chengwu Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1396307

1,658 views

Review

Published on 12 Aug 2024

Potential role of endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity-an update

in Drug Metabolism and Transport

Mingli Sun
Xin Zhang
Boxuan Tan
Qingya Zhang
Xiaopeng Zhao
Dan Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1415108

1,495 views

Original Research

Published on 07 Aug 2024

The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes

in Drug Metabolism and Transport

Jhohann Richard de Lima Benzi
Yik Pui Tsang
Jashvant D. Unadkat

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1440010

1,571 views
1 citation

Original Research

Published on 07 Aug 2024

Exploring stevioside binding affinity with various proteins and receptors actively involved in the signaling pathway and a future candidate for diabetic patients

in Drug Metabolism and Transport

Salman Khan
Nisar Ahmad
Hina Fazal
Ibrahim A. Saleh
Mostafa A. Abdel-Maksoud
Abdul Malik
Gehad AbdElgayed
Arshad Jalal
Kamran Rauf
Liaqat Ali

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1377916

1,661 views
1 citation

Editorial

Published on 05 Aug 2024

Editorial: Pharmacokinetic-pharmacodynamic model of drugs and their pharmacokinetic differences between normal and disease states

in Drug Metabolism and Transport

Zipeng Gong
Ruixing Chen
Ling Ye
Guo Ma
Yanfang Xian
Kaustubh Kulkarni

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1451176

641 views

Correction

Published on 01 Aug 2024

Corrigendum: Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury

in Drug Metabolism and Transport

Xinzhu Zhang
Wu Xiong
Guang Kong
Yushan Zhen
Qiang Zeng
Siming Wang
Sheng Chen
Jun Gu
Cong Li
Kaijin Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1451951

651 views

Review

Published on 24 Jul 2024

Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs

in Drug Metabolism and Transport

Yimei Wang
Mei-Juan Tu
Ai-Ming Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423416

1,781 views

Original Research

Published on 22 Jul 2024

A new crystalline daidzein-piperazine salt with enhanced solubility, permeability, and bioavailability

in Drug Metabolism and Transport

Jiacheng Meng
Chenxu Qiu
Chenyue Lu
Xin He
Xinghua Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1385637

1,096 views

Original Research

Published on 18 Jul 2024

Metabolic characterization of the new benzimidazole synthetic opioids - nitazenes

in Drug Metabolism and Transport

Gajanan R. Jadhav
Pius S. Fasinu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1434573

2,727 views

Original Research

Published on 16 Jul 2024

Population pharmacokinetics and exposure–response analyses of SAF-189s in Chinese patients with ALK+/ROS1+ non-small cell lung cancer

in Drug Metabolism and Transport

Yinhui Liu
Yan Tan
Lin Hu
Jinlong Li
Jiansong Yang
Lei Diao
Jin Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1418549

1,013 views

Original Research

Published on 09 Jul 2024

Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily

in Drug Metabolism and Transport

Daniela Digles
Alvaro Ingles-Prieto
Vojtech Dvorak
Tamara A. M. Mocking
Ulrich Goldmann
Andrea Garofoli
Evert J. Homan
Alberto Di Silvio
Lucia Azzollini
Francesca Sassone

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1401599

3,800 views
1 citation

Original Research

Published on 04 Jul 2024

Association of dipeptidyl peptidase-4 inhibitor and recurrent pancreatitis risk among patients with type 2 diabetes: A retrospective cohort study

in Drug Metabolism and Transport

Yi-Sun Yang
Edy Kornelius
Yu-Hsun Wang
Shih-Chan Lo
Chien-Ning Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1341363

900 views

Methods

Published on 26 Jun 2024

Pharmacokinetic profile of phenytoin in dried blood spot with high-performance liquid chromatography—photodiode array

in Drug Metabolism and Transport

Yahdiana Harahap
Limeylia Ng
Sunarsih Sunarsih

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1326996

1,297 views

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Articles

The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity

Effects of three flavonoids on the metabolism of lenvatinib

Influence of C-reactive protein on the pharmacokinetics of voriconazole in relation to the CYP2C19 genotype: a population pharmacokinetics analysis

A simple HPLC–MS/MS method for the determination of polymyxin B in human plasma and its application in the pharmacokinetic study in elderly patients infected with multidrug-resistant Gram-negative bacteria

Potential role of endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity-an update

The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes

Exploring stevioside binding affinity with various proteins and receptors actively involved in the signaling pathway and a future candidate for diabetic patients

Editorial: Pharmacokinetic-pharmacodynamic model of drugs and their pharmacokinetic differences between normal and disease states

Corrigendum: Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury

Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs

A new crystalline daidzein-piperazine salt with enhanced solubility, permeability, and bioavailability

Metabolic characterization of the new benzimidazole synthetic opioids - nitazenes

Population pharmacokinetics and exposure–response analyses of SAF-189s in Chinese patients with ALK+/ROS1+ non-small cell lung cancer

Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily

Association of dipeptidyl peptidase-4 inhibitor and recurrent pancreatitis risk among patients with type 2 diabetes: A retrospective cohort study

Pharmacokinetic profile of phenytoin in dried blood spot with high-performance liquid chromatography—photodiode array