Original Research

Published on 17 Sep 2021

Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach

in Drug Metabolism and Transport

Punyabhorn Rattanacheeworn
Stephen J Kerr
Wonngarm Kittanamongkolchai
Natavudh Townamchai
Suwasin Udomkarnjananun
Kearkiat Praditpornsilpa
Thanundorn Thanusuwannasak
Udomsak Udomnilobol
Suree Jianmongkol
Boonsri Ongpipattanakul

Frontiers in Pharmacology

doi 10.3389/fphar.2021.726669

4,307 views
15 citations

Original Research

Published on 14 Sep 2021

Sex Metabolic Differences and Effects on Blood Coagulation Among Rats Exposed to Sodium Dehydroacetate

in Drug Metabolism and Transport

Xin Chen
Fuxing Hao
Meng Zhang
Jinzha Xiao
Weiya Zhao
Zeting Zhao
Yumei Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.727084

1,850 views
6 citations

Original Research

Published on 26 Aug 2021

Influence of FMO3 and CYP3A4 Polymorphisms on the Pharmacokinetics of Teneligliptin in Humans

in Drug Metabolism and Transport

Jin-Woo Park
Kyoung-Ah Kim
Jong-Min Kim
In-Hwan Park
Ji-Young Park

Frontiers in Pharmacology

doi 10.3389/fphar.2021.736317

2,479 views
1 citation

Original Research

Published on 25 Aug 2021

Population Pharmacokinetics of Polymyxin B and Dosage Optimization in Renal Transplant Patients

in Drug Metabolism and Transport

Ying Li
Yang Deng
Zhen-Yu Zhu
Yi-Ping Liu
Ping Xu
Xin Li
Yue-Liang Xie
Heng-Chang Yao
Liu Yang
Bi-Kui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.727170

4,259 views
27 citations

Original Research

Published on 24 Aug 2021

Optimized Dosing Regimens of Meropenem in Septic Children Receiving Extracorporeal Life Support

in Drug Metabolism and Transport

Yixue Wang
Weiming Chen
Yidie Huang
Guangfei Wang
Zhiping Li
Gangfeng Yan
Chao Chen
Guoping Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.699191

6,775 views
7 citations

Original Research

Published on 24 Aug 2021

Cell-Penetrating Peptides Predicted From CASC3, AKIP1, and AHRR Proteins

in Drug Metabolism and Transport

Ly Porosk
Kaisa Põhako
Piret Arukuusk
Ülo Langel

Frontiers in Pharmacology

doi 10.3389/fphar.2021.716226

2,953 views
2 citations

Original Research

Published on 23 Aug 2021

A Comprehensive Analysis of Metabolomics and Transcriptomics Reveals Novel Biomarkers and Mechanistic Insights on Lorlatinib Crosses the Blood-Brain Barrier

in Drug Metabolism and Transport

Wei Chen
Chunyu Li
Yafei Shi
Yujun Zhang
Dujia Jin
Mingyu Zhang
Mingming Bo
Guohui Li

Frontiers in Pharmacology

doi 10.3389/fphar.2021.722627

2,915 views
3 citations

Original Research

Published on 13 Aug 2021

Distribution Evaluation of Tenofovir in the Breast Milk of Mothers With HBeAg-Positive Chronic HBV Infection After Treatment With Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate by a Sensitive UPLC-MS/MS Method

in Drug Metabolism and Transport

Na Yang
Guanlun Zhou
Xiaoliang Cheng
Jun He
Yan Chen
Chao Chen
Meijuan Li
Jiajia Ge
Min Wang
Tianqi Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.734760

4,066 views
7 citations

Original Research

Published on 13 Aug 2021

(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells

in Drug Metabolism and Transport

Alzbeta Stefela
Miroslav Kaspar
Martin Drastik
Thales Kronenberger
Stanislav Micuda
Martin Dracinsky
Blanka Klepetarova
Eva Kudova
Petr Pavek

Frontiers in Pharmacology

doi 10.3389/fphar.2021.713149

4,746 views
6 citations

Review

Published on 10 Aug 2021

An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters

in Drug Metabolism and Transport

Vojtech Dvorak
Tabea Wiedmer
Alvaro Ingles-Prieto
Patrick Altermatt
Helena Batoulis
Felix Bärenz
Eckhard Bender
Daniela Digles
Franz Dürrenberger
Laura H. Heitman

Frontiers in Pharmacology

doi 10.3389/fphar.2021.722889

22,470 views
43 citations

Original Research

Published on 04 Aug 2021

Regulation of ABC Drug Efflux Transporters in Human T-Cells Exposed to an HIV Pseudotype

in Drug Metabolism and Transport

Sana-Kay Whyte-Allman
Rupert Kaul
Reina Bendayan

Frontiers in Pharmacology

doi 10.3389/fphar.2021.711999

2,549 views
5 citations

Original Research

Published on 23 Jul 2021

Prediction of Rivaroxaban-Rifampin Interaction After Major Orthopedic Surgery: Physiologically Based Pharmacokinetic Modeling and Simulation

in Drug Metabolism and Transport

Rui-juan Xu
Tao Ling
Hong Tang
Wei-hong Ge
Qing Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.706781

6,948 views
3 citations

Original Research

Published on 15 Jul 2021

A Metabolic Pattern in Healthy Subjects Given a Single Dose of Metformin: A Metabolomics Approach

in Drug Metabolism and Transport

Lina A. Dahabiyeh
Muhammad Mujammami
Tawfiq Arafat
Hicham Benabdelkamel
Assim A. Alfadda
Anas M. Abdel Rahman

Frontiers in Pharmacology

doi 10.3389/fphar.2021.705932

5,373 views
23 citations

Original Research

Published on 15 Jul 2021

Metabolites Identification of Chemical Constituents From the Eggplant (Solanum melongena L.) Calyx in Rats by UPLC/ESI/qTOF-MS Analysis and Their Cytotoxic Activities

in Drug Metabolism and Transport

Yuanyuan Song
Ting Mei
Yan Liu
Shengnan Kong
Jincheng Zhang
Minzhen Xie
Shan Ou
Meixia Liang
Qi Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.655008

5,353 views
9 citations

Original Research

Published on 13 Jul 2021

Pharmacokinetics, Urinary Excretion, and Pharmaco-Metabolomic Study of Tebipenem Pivoxil Granules After Single Escalating Oral Dose in Healthy Chinese Volunteers

in Drug Metabolism and Transport

Zeyun Li
Mei Su
Weiyan Cheng
Jueyu Xia
Shuaibing Liu
Ruijuan Liu
Suke Sun
Luyao Feng
Xueya Zhu
Xiaojian Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.696165

7,342 views
6 citations

Original Research

Published on 01 Jul 2021

High Dose Lopinavir/Ritonavir Does Not Lead to Sufficient Plasma Levels to Inhibit SARS-CoV-2 in Hospitalized Patients With COVID-19

in Drug Metabolism and Transport

Mario Karolyi
Sara Omid
Erich Pawelka
Bernd Jilma
Thomas Stimpfl
Christian Schoergenhofer
Hermann Laferl
Tamara Seitz
Marianna Traugott
Christoph Wenisch

Frontiers in Pharmacology

doi 10.3389/fphar.2021.704767

4,289 views
9 citations

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Articles

Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach

Sex Metabolic Differences and Effects on Blood Coagulation Among Rats Exposed to Sodium Dehydroacetate

Influence of FMO3 and CYP3A4 Polymorphisms on the Pharmacokinetics of Teneligliptin in Humans

Population Pharmacokinetics of Polymyxin B and Dosage Optimization in Renal Transplant Patients

Optimized Dosing Regimens of Meropenem in Septic Children Receiving Extracorporeal Life Support

Cell-Penetrating Peptides Predicted From CASC3, AKIP1, and AHRR Proteins

A Comprehensive Analysis of Metabolomics and Transcriptomics Reveals Novel Biomarkers and Mechanistic Insights on Lorlatinib Crosses the Blood-Brain Barrier

Distribution Evaluation of Tenofovir in the Breast Milk of Mothers With HBeAg-Positive Chronic HBV Infection After Treatment With Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate by a Sensitive UPLC-MS/MS Method

(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells

An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters

Regulation of ABC Drug Efflux Transporters in Human T-Cells Exposed to an HIV Pseudotype

Prediction of Rivaroxaban-Rifampin Interaction After Major Orthopedic Surgery: Physiologically Based Pharmacokinetic Modeling and Simulation

A Metabolic Pattern in Healthy Subjects Given a Single Dose of Metformin: A Metabolomics Approach

Metabolites Identification of Chemical Constituents From the Eggplant (Solanum melongena L.) Calyx in Rats by UPLC/ESI/qTOF-MS Analysis and Their Cytotoxic Activities

Pharmacokinetics, Urinary Excretion, and Pharmaco-Metabolomic Study of Tebipenem Pivoxil Granules After Single Escalating Oral Dose in Healthy Chinese Volunteers

High Dose Lopinavir/Ritonavir Does Not Lead to Sufficient Plasma Levels to Inhibit SARS-CoV-2 in Hospitalized Patients With COVID-19