Original Research

Published on 12 Nov 2021

Serum Predose Metabolic Profiling for Prediction of Rosuvastatin Pharmacokinetic Parameters in Healthy Volunteers

in Drug Metabolism and Transport

Anne Michelli Reis Silveira
Gustavo Henrique Bueno Duarte
Anna Maria Alves de Piloto Fernandes
Pedro Henrique Dias Garcia
Nelson Rogerio Vieira
Marcia Aparecida Antonio
Patricia de Oliveira Carvalho

Frontiers in Pharmacology

doi 10.3389/fphar.2021.752960

4,870 views
3 citations

Original Research

Published on 11 Nov 2021

Herb-Drug Interaction Between Xiyanping Injection and Lopinavir/Ritonavir, Two Agents Used in COVID-19 Pharmacotherapy

in Drug Metabolism and Transport

Linhu Ye
Lei Cheng
Yan Deng
Hong Liu
Xinyu Wu
Tingting Wang
Qi Chang
Yan Zhang
Dan Wang
Zongze Li

Frontiers in Pharmacology

doi 10.3389/fphar.2021.773126

4,610 views
7 citations

Original Research

Published on 11 Nov 2021

Co-Administration of Vonoprazan, Not Tegoprazan, Affects the Pharmacokinetics of Atorvastatin in Healthy Male Subjects

in Drug Metabolism and Transport

Sejung Hwang
Jae-Wook Ko
Heechan Lee
Seokuee Kim
Bongtae Kim
Geun Seog Song
Jungryul Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2021.754849

7,520 views
2 citations

Original Research

Published on 08 Nov 2021

Baicalin Enhanced Oral Bioavailability of Sorafenib in Rats by Inducing Intestine Absorption

in Drug Metabolism and Transport

Jingyao Wei
Ruijuan Liu
Jiali Zhang
Shuaibing Liu
Dan Yan
Xueqian Wen
Xin Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2021.761763

3,238 views
8 citations

Mini Review

Published on 04 Nov 2021

Mechanistic Computational Models of Epithelial Cell Transporters-the Adorned Heroes of Pharmacokinetics

in Drug Metabolism and Transport

Jasia King
Stefan Giselbrecht
Roman Truckenmüller
Aurélie Carlier

Frontiers in Pharmacology

doi 10.3389/fphar.2021.780620

2,084 views
6 citations

Original Research

Published on 02 Nov 2021

Therapeutic Drug Monitoring and Pharmacogenetic Testing in Northern China

in Drug Metabolism and Transport

Chunyan Zhang
Jing Lei
Yi Liu
Yu Wang
Lin Huang
Yufei Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2021.754380

3,006 views
7 citations

Original Research

Published on 29 Oct 2021

Comparing the Effect of Piperine and Ilepcimide on the Pharmacokinetics of Curcumin in SD Rats

in Drug Metabolism and Transport

Peijian Wang
Hui Li
Zhexuan Lin
Hongjun Luo
Wenhong Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2021.725362

3,304 views
8 citations

Original Research

Published on 28 Oct 2021

A Novel System for Evaluating the Inhibition Effect of Drugs on Cytochrome P450 Enzymes in vitro Based on Human-Induced Hepatocytes (hiHeps)

in Drug Metabolism and Transport

Yan Li
Ying-Yuan Lu
Jun Jia
Meng Fang
Lin Zhao
Yong Jiang
Yan Shi
Peng-Fei Tu
Xiao-Yu Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2021.748658

2,514 views
3 citations

Review

Published on 20 Oct 2021

Metabolic Activation of the Toxic Natural Products From Herbal and Dietary Supplements Leading to Toxicities

in Drug Metabolism and Transport

Yi-Kun Wang
Wen Qun Li
Shuang Xia
Lin Guo
Yan Miao
Bi-Kui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.758468

5,986 views
27 citations

Original Research

Published on 19 Oct 2021

Effect of CYP3A4 Inhibitors and Inducers on Pharmacokinetics and Pharmacodynamics of Saxagliptin and Active Metabolite M2 in Humans Using Physiological-Based Pharmacokinetic Combined DPP-4 Occupancy

in Drug Metabolism and Transport

Gang Li
Bowen Yi
Jingtong Liu
Xiaoquan Jiang
Fulu Pan
Wenning Yang
Haibo Liu
Yang Liu
Guopeng Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.746594

5,633 views
12 citations

Original Research

Published on 14 Oct 2021

Contributions of UDP-Glucuronosyltransferases to Human Hepatic and Intestinal Metabolism of Ticagrelor and Inhibition of UGTs and Cytochrome P450 Enzymes by Ticagrelor and its Glucuronidated Metabolite

in Drug Metabolism and Transport

Shuaibing Liu
Lei Hou
Cai Li
Yibo Zhao
Xia Yao
Xiaojian Zhang
Xin Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2021.761814

2,884 views
9 citations

Original Research

Published on 08 Oct 2021

Preparation of MSZ Hydrogel and Its Treatment of Colitis

in Drug Metabolism and Transport

Yanhong Wu
Shangyong Li
Mengfei Jin
Dandan Li
Zihan Zhou
Haiqing Hou
Yantao Han

Frontiers in Pharmacology

doi 10.3389/fphar.2021.706401

4,267 views
6 citations

Original Research

Published on 06 Oct 2021

The Dynamic Effect of Non-CYP3A4-Metabolized and CYP3A4-Metabolized Statins on Clopidogrel Resistance in Patients With Cerebral Infarction

in Drug Metabolism and Transport

Hong Ting Shi
Yong Yuan Chen
Xiao Ying Li
Jian Hua Luo
Guang Hong Zhong
Jia Jia Hu
Min Zhang
Bo Rong Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2021.738562

2,243 views

Original Research

Published on 01 Oct 2021

Resveratrol on the Metabolic Reprogramming in Liver: Implications for Advanced Atherosclerosis

in Drug Metabolism and Transport

Ying Ma
Dongliang Li
Wenfeng Liu
Xiaoxiao Liu
Yingqi Xu
Xinrui Zhong
Fengnan Zhi
Xueling Jia
Yanan Jiang
Yuhua Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2021.747625

4,593 views
10 citations

Original Research

Published on 27 Sep 2021

Evaluation of a Clinically Relevant Drug–Drug Interaction Between Rosuvastatin and Clopidogrel and the Risk of Hepatotoxicity

in Drug Metabolism and Transport

Chen Ning
Shengdi Su
Jiaming Li
Dexuan Kong
Hui Cai
Zhiying Qin
Han Xing
Xijing Chen
Jiake He

Frontiers in Pharmacology

doi 10.3389/fphar.2021.715577

6,554 views
4 citations

Original Research

Published on 17 Sep 2021

Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach

in Drug Metabolism and Transport

Punyabhorn Rattanacheeworn
Stephen J Kerr
Wonngarm Kittanamongkolchai
Natavudh Townamchai
Suwasin Udomkarnjananun
Kearkiat Praditpornsilpa
Thanundorn Thanusuwannasak
Udomsak Udomnilobol
Suree Jianmongkol
Boonsri Ongpipattanakul

Frontiers in Pharmacology

doi 10.3389/fphar.2021.726669

4,307 views
14 citations

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Articles

Serum Predose Metabolic Profiling for Prediction of Rosuvastatin Pharmacokinetic Parameters in Healthy Volunteers

Herb-Drug Interaction Between Xiyanping Injection and Lopinavir/Ritonavir, Two Agents Used in COVID-19 Pharmacotherapy

Co-Administration of Vonoprazan, Not Tegoprazan, Affects the Pharmacokinetics of Atorvastatin in Healthy Male Subjects

Baicalin Enhanced Oral Bioavailability of Sorafenib in Rats by Inducing Intestine Absorption

Mechanistic Computational Models of Epithelial Cell Transporters-the Adorned Heroes of Pharmacokinetics

Therapeutic Drug Monitoring and Pharmacogenetic Testing in Northern China

Comparing the Effect of Piperine and Ilepcimide on the Pharmacokinetics of Curcumin in SD Rats

A Novel System for Evaluating the Inhibition Effect of Drugs on Cytochrome P450 Enzymes in vitro Based on Human-Induced Hepatocytes (hiHeps)

Metabolic Activation of the Toxic Natural Products From Herbal and Dietary Supplements Leading to Toxicities

Effect of CYP3A4 Inhibitors and Inducers on Pharmacokinetics and Pharmacodynamics of Saxagliptin and Active Metabolite M2 in Humans Using Physiological-Based Pharmacokinetic Combined DPP-4 Occupancy

Contributions of UDP-Glucuronosyltransferases to Human Hepatic and Intestinal Metabolism of Ticagrelor and Inhibition of UGTs and Cytochrome P450 Enzymes by Ticagrelor and its Glucuronidated Metabolite

Preparation of MSZ Hydrogel and Its Treatment of Colitis

The Dynamic Effect of Non-CYP3A4-Metabolized and CYP3A4-Metabolized Statins on Clopidogrel Resistance in Patients With Cerebral Infarction

Resveratrol on the Metabolic Reprogramming in Liver: Implications for Advanced Atherosclerosis

Evaluation of a Clinically Relevant Drug–Drug Interaction Between Rosuvastatin and Clopidogrel and the Risk of Hepatotoxicity

Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach