Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 31 Mar 2025

In Vivo pharmacokinetic interactions of ribociclib with rivaroxaban and apixaban in rats: implications for increased drug exposure and dose adjustments

in Drug Metabolism and Transport

Zihan Liu
Wenyu Du
Qimin Wang
Zhi Wang
Jing An
Yinling Ma
Zhanjun Dong
Ying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1530806

538 views

Original Research

Published on 31 Mar 2025

Physiologically based pharmacokinetic model of sodium-glucose cotransporter 2 inhibitors predicted pharmacokinetics and pharmacodynamics to explore dosage regimen for patients with type 2 diabetes mellitus and renal insufficiency

in Drug Metabolism and Transport

Guimu Guo
Meng Ke
Jianwen Xu
Wanhong Wu
Jiarui Chen
Chengjie Ke
Pinfang Huang
Cuihong Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1520268

474 views

Original Research

Published on 28 Mar 2025

Escitalopram oxalate-loaded chitosan nanoparticle in situ gel formulation intended for direct nose-to-brain delivery: in vitro, ex vivo, and in vivo pharmacokinetic evaluation

in Drug Metabolism and Transport

Md Ali Mujtaba
Md Abdur Rashid
Mangesh D. Godbole
Yahya Alhamhoom
Divyashri S. Shende
Sameer Alshehri
Mohammad J. Akbar
Mohammed Kaleem
Ujwala N. Mahajan
Naiyer Shahzad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577331

546 views

Original Research

Published on 28 Mar 2025

Influence of the ABCB1-rs1045642 gene polymorphism on blood drug concentration in voriconazole-treated patients with severe invasive fungal infection

in Drug Metabolism and Transport

Qian Zhang
Xing Gao
Dongmei Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510890

335 views

Original Research

Published on 27 Mar 2025

Pharmacokinetic simulations for remdesivir and its metabolites in healthy subjects and patients with renal impairment

in Drug Metabolism and Transport

Shengjie Zhang
Sunggyeol Jeong
Botao Jiang
Harvey Ho

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1488961

502 views

Original Research

Published on 27 Mar 2025

High-performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring

in Drug Metabolism and Transport

Jinglong Wang
Junjie Wang
Chenxiao Zhang
Guofei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531496

484 views

Original Research

Published on 26 Mar 2025

Comparison of the pharmacokinetic variations of different concentrations of ropivacaine used for serratus anterior plane block in patients undergoing thoracoscopic lobectomy: a population pharmacokinetics analysis

in Drug Metabolism and Transport

Jing Ling
Caomei Xu
Lingkai Tang
Lan Qiu
Nan Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1540606

324 views

Original Research

Accepted on 25 Mar 2025

Automated Fluorine-18 Radiolabelling via Alkyne-azide Cycloaddition Reaction on Dual Peptide-functionalized Liposomes Surface for in vivo PET Imaging

in Drug Metabolism and Transport

Marco Iannone
Marcelo Kravicz
Paolo Rainone
Antonia Antoniou
Stefano Stucchi
Silvia Valtorta
Arianna Amenta
Elia Anna Turolla
Sara Pellegrino
Daniele Passarella

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566257

152 views

Clinical Trial

Accepted on 24 Mar 2025

Pharmacokinetics and bioequivalence assessment of two prucalopride formulations in healthy Chinese women: a randomized, open-label, two-period, two-sequence, self-crossover study

in Drug Metabolism and Transport

Xiangxin Huang
Ying Wang
Bei Li
Xiaoqun Shen
Xuexia Tao
Wenwen Zheng
Qi Luo
Lei Xiong
Lin Wang
Shufan Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562692

Clinical Trial

Published on 19 Mar 2025

A randomized, open-label, two-period crossover study to evaluate the bioequivalence and food effect between two formulations of regorafenib in healthy adult participants

in Drug Metabolism and Transport

Yan Li
Lu Qi
Caixia Yang
Na Zhao
Xinghe Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1511558

535 views

Review

Published on 18 Mar 2025

Evolution of nMOFs in photodynamic therapy: from porphyrins to chlorins and bacteriochlorins for better efficacy

in Drug Metabolism and Transport

Yutao Zou
Jiayi Chen
Yijie Qu
Xuanxuan Luo
Weiqi Wang
Xiaohua Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533040

507 views

Original Research

Published on 12 Mar 2025

Molecular determinants of neuroprotection in blood-brain interfaces of the cynomolgus monkey

in Drug Metabolism and Transport

Nathalie Strazielle
Sandrine Blondel
Joachim Confais
Rita El Khoury
Hugues Contamin
Jean-François Ghersi-Egea

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1523819

655 views

Original Research

Published on 12 Mar 2025

Bioequivalence of China- and Germany-manufactured bisoprolol (Concor®) tablets in fasted and fed healthy Chinese participants: a randomized, open-label, two-way, crossover study

in Drug Metabolism and Transport

Hang Yin
Zhili Jin
Ran Li
Dandan Li
Lusha Wang
Ruihua Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1527623

544 views

Opinion

Published on 06 Mar 2025

Two-faced Janus SkQ1/SkQR1: patterns and molecular volume threshold for substrate recognition by the AcrAB-TolC pump

in Drug Metabolism and Transport

Marina V. Karakozova
Alexandra I. Sorochkina
Pavel A. Nazarov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1480955

417 views

Original Research

Published on 04 Mar 2025

Model-informed drug development of novel ROCK2 inhibitor TDI01: population pharmacokinetic study and simulation

in Drug Metabolism and Transport

Xiwei Ji
Yimin Cui

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1477607

518 views

Review

Published on 04 Mar 2025

Microalgae in health care and functional foods: β-glucan applications, innovations in drug delivery and synthetic biology

in Drug Metabolism and Transport

Chao Li
Ming Du
Yujie Han
Wentao Sun
Zixi Chen
Qiong Liu
Hui Zhu
Liqing Zhao
Shuangfei Li
Jiangxin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557298

967 views