Original Research

Published on 04 Dec 2024

Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study

in Drug Metabolism and Transport

Tayyaba Iftikhar
Zafar Iqbal
Yasar Shah
Nauman Rahim Khan
Muhammad Abbas
Omer Shehzad
Fazal Hadi
Haseeba Sardar
Ali Abusharha
Maria Daglia

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467805

345 views

Original Research

Published on 03 Dec 2024

Computational studies for pre-evaluation of pharmacological profile of gut microbiota-produced gliclazide metabolites

in Drug Metabolism and Transport

Maja Đanić
Nebojša Pavlović
Dragana Zaklan
Bojan Stanimirov
Slavica Lazarević
Hani Al-Salami
Momir Mikov

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1492284

282 views

Original Research

Accepted on 02 Dec 2024

UGT2B15 Single Nucleotide Polymorphism Reduces Dabigatran Acylglucuronide Formation in Humans

in Drug Metabolism and Transport

Jin-Woo Park
Jong-Min Kim
Young Yoon Bang
Kyoung-Ah Kim
Sungwook Yu
Ji-Young Park

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1507915

Original Research

Published on 20 Nov 2024

Mulberry leaf ameliorate STZ induced diabetic rat by regulating hepatic glycometabolism and fatty acid β-oxidation

in Drug Metabolism and Transport

Bohan Lv
Siyuan Liu
Yaqi Li
Zhigang Li
Yongcheng An
Changhao He
Huilin Zhang
Yan Huang
Wanxin Fu
Quantao Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1428604

600 views

Original Research

Published on 20 Nov 2024

Evaluation of pharmacokinetics and relative bioavailability of pentoxifylline and its metabolite in beagle dogs following different formulations

in Drug Metabolism and Transport

Yuxiang Xu
Hongxin Qie
Haopeng Zhao
Wenlin Gong
Peiyuan Wang
Xiaonan Gao
Jinglin Gao
Zhangying Feng
Mingxia Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488076

357 views

Clinical Trial

Published on 15 Nov 2024

Mass balance, metabolism, and pharmacokinetics of [14C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin’s lymphoma, in healthy Chinese volunteers

in Drug Metabolism and Transport

Chun-Yang Zhao
Li-Jun Zhang
Chan Sun
Cheng-Yin Yu
Jian Wang
Yang Sai
Wei-Guo Su
Qian Chen
Wei Wang
Jing-Ying Jia

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1478234

648 views

Original Research

Published on 08 Nov 2024

Combined carbapenem resulted in a 4.48-fold increase in valproic acid clearance: a population pharmacokinetic model in Chinese children and adults with epilepsy or after neurosurgery

in Drug Metabolism and Transport

Luofei Zhang
Ruoyun Wu
Xingmeng Li
Weixing Feng
Zhigang Zhao
Shenghui Mei

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423411

339 views

Original Research

Published on 07 Nov 2024

In vitro, in vivo, and in silico approaches for evaluating the preclinical DMPK profiles of ammoxetine, a novel chiral serotonin and norepinephrine reuptake inhibitor

in Drug Metabolism and Transport

Xiuqing Zhu
Yuexin Li
Huan Luo
Yunxia Zhang
Zhenqing Zhang
Jinglai Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486856

677 views

Original Research

Published on 06 Nov 2024

Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

in Drug Metabolism and Transport

Milda Girdenytė
Yang Hu
Aghavni Ginosyan
Margareta Hammarlund-Udenaes
Irena Loryan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486686

744 views

Mini Review

Published on 05 Nov 2024

Evaluating in vivo data for drug metabolism and transport: lessons from Kirchhoff’s Laws

in Drug Metabolism and Transport

Leslie Z. Benet
Jasleen K. Sodhi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1456677

332 views

Original Research

Published on 24 Oct 2024

Pharmacokinetics study of atracurium, dexmedetomidine, midazolam and 1-hydroxymidazolam in patients undergoing acute aortic dissection surgery

in Drug Metabolism and Transport

Huiling Si
Xuanxuan Xu
Yuhao Liang
Shuaibo Shi
Fan Xie
Jie Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1427553

416 views

Review

Published on 23 Oct 2024

Porphyrin-engineered nanoscale metal-organic frameworks: enhancing photodynamic therapy and ferroptosis in oncology

in Drug Metabolism and Transport

Yutao Zou
Jiayi Chen
Xuanxuan Luo
Yijie Qu
Mengjiao Zhou
Rui Xia
Weiqi Wang
Xiaohua Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1481168

618 views

Original Research

Published on 09 Oct 2024

Study on biotransformation and absorption of genistin based on fecal microbiota and Caco-2 cell

in Drug Metabolism and Transport

Zhe Li
Yuqing Wang
Zicheng Wang
Dongxue Wu
Yuhao Zhao
Xun Gong
Quan Jiang
Congmin Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437020

727 views

Correction

Published on 27 Sep 2024

Corrigendum: Inhibitory effects of calcium channel blockers nisoldipine and nimodipine on ivacaftor metabolism and their underlying mechanism

in Drug Metabolism and Transport

Hailun Xia
Xinhao Xu
Jie Chen
Hualu Wu
Yuxin Shen
Xiaohai Chen
Ren-ai Xu
Wenzhi Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1495855

362 views

Original Research

Published on 23 Sep 2024

Study of transport, tissue distribution, depletion, and hepatotoxicity of Cyadox, a quinoxaline-1,4-dioxide derivative

in Drug Metabolism and Transport

Zhu Tao
Changchun Li
Aiqun Zhang
Zhilin Zhang
Jing Huang
Sechenchogt Harnud

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1401275

443 views

Methods

Published on 20 Sep 2024

A validated UPLC-MS/MS method for quantification of pyrotinib and population pharmacokinetic study of pyrotinib in HER2-positive breast cancer patients

in Drug Metabolism and Transport

Yunfang Zhu
Yuxiang Xu
Haopeng Zhao
Hongxin Qie
Xiaonan Gao
Jinglin Gao
Zhangying Feng
Jing Bai
Rui Feng
Mingxia Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1432944

715 views

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Articles

Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study

Computational studies for pre-evaluation of pharmacological profile of gut microbiota-produced gliclazide metabolites

UGT2B15 Single Nucleotide Polymorphism Reduces Dabigatran Acylglucuronide Formation in Humans

Mulberry leaf ameliorate STZ induced diabetic rat by regulating hepatic glycometabolism and fatty acid β-oxidation

Evaluation of pharmacokinetics and relative bioavailability of pentoxifylline and its metabolite in beagle dogs following different formulations

Mass balance, metabolism, and pharmacokinetics of [14C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin’s lymphoma, in healthy Chinese volunteers

Combined carbapenem resulted in a 4.48-fold increase in valproic acid clearance: a population pharmacokinetic model in Chinese children and adults with epilepsy or after neurosurgery

In vitro, in vivo, and in silico approaches for evaluating the preclinical DMPK profiles of ammoxetine, a novel chiral serotonin and norepinephrine reuptake inhibitor

Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

Evaluating in vivo data for drug metabolism and transport: lessons from Kirchhoff’s Laws

Pharmacokinetics study of atracurium, dexmedetomidine, midazolam and 1-hydroxymidazolam in patients undergoing acute aortic dissection surgery

Porphyrin-engineered nanoscale metal-organic frameworks: enhancing photodynamic therapy and ferroptosis in oncology

Study on biotransformation and absorption of genistin based on fecal microbiota and Caco-2 cell

Corrigendum: Inhibitory effects of calcium channel blockers nisoldipine and nimodipine on ivacaftor metabolism and their underlying mechanism

Study of transport, tissue distribution, depletion, and hepatotoxicity of Cyadox, a quinoxaline-1,4-dioxide derivative

A validated UPLC-MS/MS method for quantification of pyrotinib and population pharmacokinetic study of pyrotinib in HER2-positive breast cancer patients