Original Research

Published on 31 Oct 2022

Plasma metabolomic profiling reveals factors associated with dose-adjusted trough concentration of tacrolimus in liver transplant recipients

in Drug Metabolism and Transport

Huaijun Zhu
Min Wang
Xiaofu Xiong
Yao Du
Danying Li
Zhou Wang
Weihong Ge
Yizhun Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1045843

2,349 views
4 citations

Original Research

Published on 28 Oct 2022

Knockout of ABC transporters by CRISPR/Cas9 contributes to reliable and accurate transporter substrate identification for drug discovery

in Drug Metabolism and Transport

Dongyan Feng
Guorui Zhong
Qingxia Zuo
Yanbin Wan
Wanqing Xu
Changsheng He
Cailing Lin
Dongchao Huang
Feng Chen
Lizhen Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1015940

2,591 views
3 citations

Original Research

Published on 25 Oct 2022

Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatment with Polygonum capitatum Buch.-Ham. ex D. Don extracts

in Drug Metabolism and Transport

Ziqiang Li
Xi Du
Shuang Tian
Shanshan Fan
Xurui Zuo
Yanfen Li
Ruihua Wang
Baohe Wang
Yuhong Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1033667

2,050 views
1 citation

Original Research

Published on 24 Oct 2022

Plasma metabolomic and lipidomic alterations associated with anti-tuberculosis drug-induced liver injury

in Drug Metabolism and Transport

Ming-Gui Wang
Shou-Quan Wu
Meng-Meng Zhang
Jian-Qing He

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1044808

3,296 views
11 citations

Original Research

Published on 24 Oct 2022

Applying machine learning to the pharmacokinetic modeling of cyclosporine in adult renal transplant recipients: a multi-method comparison

in Drug Metabolism and Transport

Junjun Mao
Yuhao Chen
Luyang Xu
Weihuang Chen
Biwen Chen
Zhuo Fang
Weiwei Qin
Mingkang Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1016399

3,109 views
7 citations

Original Research

Published on 21 Oct 2022

Action mechanism of hypoglycemic principle 9-(R)-HODE isolated from cortex lycii based on a metabolomics approach

in Drug Metabolism and Transport

Yueqiu Liu
Xinyi Hu
Wen Zheng
Lu Zhang
Luolan Gui
Ge Liang
Yong Zhang
Liqiang Hu
Xin Li
Yi Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1011608

2,834 views
4 citations

Original Research

Published on 19 Oct 2022

SHR2285, the first selectively oral FXIa inhibitor in China: Safety, tolerability, pharmacokinetics and pharmacodynamics combined with aspirin, clopidogrel or ticagrelor

in Drug Metabolism and Transport

Tingting Ma
Yanli Dong
Lei Huang
Yuanxun Yang
Yan Geng
Fei Fei
Pinhao Xie
Yu Zhao
Hui Lin
Zeyu Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1027627

2,492 views
6 citations

Correction

Published on 14 Oct 2022

Corrigendum: Impact of sampling time variability on tacrolimus dosage regimen in pediatric primary nephrotic syndrome: Single-center, prospective, observational study

in Drug Metabolism and Transport

Lingfei Huang
Junyan Wang
Jufei Yang
Huifen Zhang
Yan Hu
Jing Miao
Jianhua Mao
Luo Fang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1051794

653 views

Original Research

Published on 13 Oct 2022

Phospholipid-mimicking block, graft, and block-graft copolymers for phase-transition microbubbles as ultrasound contrast agents

in Drug Metabolism and Transport

Jianbo Huang
Hong Wang
Lei Huang
Yuqing Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2022.968835

1,159 views
1 citation

Review

Published on 11 Oct 2022

The status of industrialization and development of exosomes as a drug delivery system: A review

in Drug Metabolism and Transport

Yi Yin
Xing Han
Cheng Li
Tonghui Sun
Kailin Li
Xionghao Liu
Mujun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.961127

2,890 views
8 citations

Methods

Published on 11 Oct 2022

Determination of (-)-epigallocatechin-3-gallate octaacetate and its metabolites in plasma of rats for pharmacokinetic study by ultra-performance-liquid-chromatography coupled to quadrupole-time-of-flight-mass-spectrometry

in Drug Metabolism and Transport

Kai On Chu
Gene Chi Wai Man
Sze Wan Hung
Tak Hang Chan
Wai Yip Thomas Lee
Kwok Ping Chan
Chi Pui Pang
Chi Chiu Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1025053

1,595 views

Review

Published on 10 Oct 2022

Application of traditional Chinese medicine in film drug delivery system

in Drug Metabolism and Transport

Qianhang Li
Feng Luo
Pingnan Jiang
Chenxi Feng
Feifei He
Lina Dong
Delin Xu
Junhua Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2022.956264

7,190 views

Original Research

Published on 10 Oct 2022

Use of modeling and simulation to predict the influence of triazole antifungal agents on the pharmacokinetics of zanubrutinib and acalabrutinib

in Drug Metabolism and Transport

Lu Chen
Chao Li
Hao Bai
Lixian Li
Wanyi Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2022.960186

2,264 views
3 citations

Original Research

Published on 07 Oct 2022

SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™

in Drug Metabolism and Transport

Muhammad Talha Saleem
Muhammad Harris Shoaib
Rabia Ismail Yousuf
Farrukh Rafiq Ahmed
Kamran Ahmed
Fahad Siddiqui
Zafar Alam Mahmood
Muhammad Sikandar
Muhammad Suleman Imtiaz

Frontiers in Pharmacology

doi 10.3389/fphar.2022.974715

3,536 views
3 citations

Review

Published on 07 Oct 2022

Analyzing the metabolic fate of oral administration drugs: A review and state-of-the-art roadmap

in Drug Metabolism and Transport

Liu Liu
Yiming Liu
Xiaojie Zhou
Zhiwei Xu
Yehui Zhang
Liting Ji
Chunlan Hong
Changyu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2022.962718

4,159 views

Original Research

Published on 05 Oct 2022

Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil

in Drug Metabolism and Transport

Chaozhuang Shen
Dahu Liang
Xiaohu Wang
Wenxin Shao
Kuo Geng
Xingwen Wang
Hua Sun
Haitang Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1013432

2,581 views
8 citations

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Articles

Plasma metabolomic profiling reveals factors associated with dose-adjusted trough concentration of tacrolimus in liver transplant recipients

Knockout of ABC transporters by CRISPR/Cas9 contributes to reliable and accurate transporter substrate identification for drug discovery

Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatment with Polygonum capitatum Buch.-Ham. ex D. Don extracts

Plasma metabolomic and lipidomic alterations associated with anti-tuberculosis drug-induced liver injury

Applying machine learning to the pharmacokinetic modeling of cyclosporine in adult renal transplant recipients: a multi-method comparison

Action mechanism of hypoglycemic principle 9-(R)-HODE isolated from cortex lycii based on a metabolomics approach

SHR2285, the first selectively oral FXIa inhibitor in China: Safety, tolerability, pharmacokinetics and pharmacodynamics combined with aspirin, clopidogrel or ticagrelor

Corrigendum: Impact of sampling time variability on tacrolimus dosage regimen in pediatric primary nephrotic syndrome: Single-center, prospective, observational study

Phospholipid-mimicking block, graft, and block-graft copolymers for phase-transition microbubbles as ultrasound contrast agents

The status of industrialization and development of exosomes as a drug delivery system: A review

Determination of (-)-epigallocatechin-3-gallate octaacetate and its metabolites in plasma of rats for pharmacokinetic study by ultra-performance-liquid-chromatography coupled to quadrupole-time-of-flight-mass-spectrometry

Application of traditional Chinese medicine in film drug delivery system

Use of modeling and simulation to predict the influence of triazole antifungal agents on the pharmacokinetics of zanubrutinib and acalabrutinib

SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™

Analyzing the metabolic fate of oral administration drugs: A review and state-of-the-art roadmap

Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil