Original Research

Accepted on 19 Dec 2024

Evaluation of Drug-Drug Interaction between Suraxavir Marboxil (GP681) and Itraconazole, and Assessment of the Impact of Gene Polymorphism

in Drug Metabolism and Transport

Mai Han
Gang Cui
Yan Zhao
Xianbo Zuo
Xiaoxue Wang
Xin Zhang
Na Mi
Jiangli Jin
Chunyan Xiao
Jing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505557

Original Research

Published on 19 Dec 2024

Pharmacokinetics, bioavailability, and tissue distribution of MRTX1133 in rats using UHPLC-MS/MS

in Drug Metabolism and Transport

Wei Lu
Rong Zeng
Meng Pan
Yuan Zhou
Huijuan Tang
Wanying Shen
Yijun Tang
Pan Lei

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1509319

280 views

Original Research

Accepted on 18 Dec 2024

stormTB: A web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments

in Drug Metabolism and Transport

Roberto Visintainer
Anna Fochesato
Daniele Boaretti
Stefano Giampiccolo
Shayne Watson
Micha Levi
Federico Reali
Luca Marchetti

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1462193

Original Research

Accepted on 18 Dec 2024

LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia

in Drug Metabolism and Transport

Mihaela Butiulca
Lenard Farczadi
Silvia Imre
Camil Eugen Vari
Laurian Vlase
Bogdan Cordos
Leonard Azamfirei
Lazar Alexandra

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1494646

Original Research

Accepted on 18 Dec 2024

Effect of Low-Frequency Nnon-Focus Ultrasound Combined with Microbubbles Therapy on Tumor Hhypoxic Microenvironment

in Drug Metabolism and Transport

Yuyi Feng
DanXia Qiu
Yangcheng He
Hai Jin
Liping Chen
Fen Xi
Zhiwen Hu
Yanlin Xie
Yucai Li
Minhua Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1502349

Original Research

Accepted on 17 Dec 2024

Effects of acteoside from Cistanche tubulosa on the plasma metabolome of Cancer-related fatigue mice inoculated with colon cancer cells

in Drug Metabolism and Transport

Shilei Zhang
Fukai Gong
Jiali Liu
Shuping You
Tao Liu
Jianhua Yang
Junping Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1370264

Original Research

Accepted on 17 Dec 2024

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

in Drug Metabolism and Transport

Xiaoting Gu
Xiaohe Li
Weixue Tian
Chaoyue Zheng
Yutian Cai
Xiang Xu
Conglu Zhao
Hongting Liu
Yao Sun
Zhilin Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1510903

Original Research

Published on 16 Dec 2024

Population pharmacokinetic and pharmacodynamic model guided weight-tiered dose of AST-001 in pediatric patients with autism spectrum disorder

in Drug Metabolism and Transport

Soyoung Lee
Su-Kyeong Hwang
Jung-Sook Cho
Hyung Chul Ryu
Jae-Yong Chung

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1452526

216 views

Original Research

Accepted on 13 Dec 2024

Amphotericin B Tissue Penetration and Pharmacokinetics in Healthy and Candida albicans-Infected Rats: Insights from Microdialysis and Population Modeling

in Drug Metabolism and Transport

Valdeene Vieira Santos
Laiz Campos Pereira
Jackeline Marley Santos de Araujo
Matheus Antonio da Hora Borges
Carolina Magalhaes Brandao
Luisa Oliveira Santos
Cristiane Flora Villarreal
Francine Johansson Azeredo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1515462

Original Research

Accepted on 11 Dec 2024

The effects of clinical and pharmacological factors on the ratio of clozapine to norclozapine in psychiatric patients

in Drug Metabolism and Transport

Anna Mach
Anna Wnorowska
Marcin Siwek
Marcin Wojnar
Maria Radziwon-Zaleska

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1518739

Clinical Trial

Accepted on 09 Dec 2024

Evaluating the pharmacokinetics and safety of Blonanserin tablets and Lonasen ® : A randomized, open-label, two-period, two-sequence, self-crossover phase I clinical trial

in Drug Metabolism and Transport

Bo Qiu
Haojing Song
Xue Sun
Congyang Ding
Runxuan Du
Wanjun Bai
Zhanjun Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1511214

Methods

Accepted on 09 Dec 2024

Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma

in Drug Metabolism and Transport

Jiahui Lin
Aiting Jiang
Juntao Zheng
Jingjing Wu
Hao Li
Shirong Cai
Yu-Long He
Xiao Chen
Zhong Guoping
Xinhua Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1506931

Original Research

Accepted on 09 Dec 2024

Bioequivalence Study of Fluticasone Propionate Nebuliser Suspensions in Healthy Chinese Subjects

in Drug Metabolism and Transport

Feng Cheng
Tao Shen
Fucheng Zhang
Chenghao Lei
Ye Zhu
Guojun Luo
Dawei Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1452596

Original Research

Accepted on 05 Dec 2024

Ceftriaxone-associated dysbiosis decreases voriconazole bioavailability by upregulating intestinal P-glycoprotein expression through activation of the Nrf2-mediated signalling pathway

in Drug Metabolism and Transport

Xiaokang Wang
Chunxiao Ye
Maoxun Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1522271

Original Research

Published on 05 Dec 2024

Mass balance, metabolic disposition, and pharmacokinetics of a single IV dose of [14C]CA102N in HT-29 xenograft athymic nude mice

in Drug Metabolism and Transport

Eskouhie Tchaparian
Hua-Yang Lin
Yuchih Chen
J. Neil Hunter
Sindy Yin
Huey Ng
Albert Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1440679

281 views

Original Research

Published on 04 Dec 2024

Development of a UPLC-MS/MS method for the determination of sulfatinib and its no interaction with myricetin in rats

in Drug Metabolism and Transport

Dongxin Chen
Jie Chen
Hailun Xia
Xiaohai Chen
Jinyu Hu
Guangliang Wu
Xuegu Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1498339

191 views

Navigation group

Articles

Evaluation of Drug-Drug Interaction between Suraxavir Marboxil (GP681) and Itraconazole, and Assessment of the Impact of Gene Polymorphism

Pharmacokinetics, bioavailability, and tissue distribution of MRTX1133 in rats using UHPLC-MS/MS

stormTB: A web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments

LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia

Effect of Low-Frequency Nnon-Focus Ultrasound Combined with Microbubbles Therapy on Tumor Hhypoxic Microenvironment

Effects of acteoside from Cistanche tubulosa on the plasma metabolome of Cancer-related fatigue mice inoculated with colon cancer cells

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

Population pharmacokinetic and pharmacodynamic model guided weight-tiered dose of AST-001 in pediatric patients with autism spectrum disorder

Amphotericin B Tissue Penetration and Pharmacokinetics in Healthy and Candida albicans-Infected Rats: Insights from Microdialysis and Population Modeling

The effects of clinical and pharmacological factors on the ratio of clozapine to norclozapine in psychiatric patients

Evaluating the pharmacokinetics and safety of Blonanserin tablets and Lonasen ® : A randomized, open-label, two-period, two-sequence, self-crossover phase I clinical trial

Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma

Bioequivalence Study of Fluticasone Propionate Nebuliser Suspensions in Healthy Chinese Subjects

Ceftriaxone-associated dysbiosis decreases voriconazole bioavailability by upregulating intestinal P-glycoprotein expression through activation of the Nrf2-mediated signalling pathway

Mass balance, metabolic disposition, and pharmacokinetics of a single IV dose of [14C]CA102N in HT-29 xenograft athymic nude mice

Development of a UPLC-MS/MS method for the determination of sulfatinib and its no interaction with myricetin in rats