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REVIEW article
Front. Pharmacol.
Sec. Inflammation Pharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1491633
This article is part of the Research Topic The Mechanisms of Fibrotic Disorders and Pharmacological Therapies View all 6 articles
The Impact of Diabetes Mellitus on Tendon Pathology: A Review
Provisionally accepted
Jian Xu
1*
Jinbo Wang
2*
Yuncong Ji
1*
JISHI JIANG
1
Yanbo Wang
1*
Xilong Cui
1
Yunpeng Wan
1*
Biao Guo
1*
Haiyang Yu
1*- 1 Department of Orthopedics, Sports Medicine and Arthroscopy. Affiliated Fuyang People's Hospital of Anhui Medical University, No. 501, Sanqing Road, Yingzhou District, Fuyang City,Anhui Province, China
- 2 Shanghai Jiao Tong University School of Medicine, No. 937 Zhongshan South 1st Road, Huangpu District, Shanghai, China
Diabetes is one of the most common metabolic diseases worldwide, leading to complications, mortality, and significant healthcare expenditures, which impose a substantial social and financial burden globally. A diabetic environment can induce metabolic changes, negatively affecting tendon homeostasis, leading to alterations in biomechanical properties and histopathology. Numerous studies have investigated the mechanisms through which diabetes exerts pathological effects on tendons, including increased free radical production, oxidative stress, inflammatory responses, deposition of advanced glycation end products (AGEs), and microvascular changes. These metabolic changes damages tendon structure, biomechanics, and tendon repair processes. The proliferation of tendon stem cells decreases, apoptosis increases, and abnormal differentiation, along with abnormal expression of myofibroblasts, ultimately lead to insufficient tendon repair, fibrosis, and remodeling. Although researches unveiling the effects of diabetes on tendinopathy, fibrosis or contracture, and tendon injury healing are growing, systematic understanding is still lacking. Therefore, this review summarizes the current research status and provides a comprehensive overview, offering theoretical guidance for future in-depth exploration of the impact of diabetes on tendons and the development of treatments for diabetes-related tendon diseases.
Keywords: diabetes, Tendon, Tendinopathy, Pathology, Fibrosis
Received: 05 Sep 2024; Accepted: 10 Oct 2024.
Copyright: © 2024 Xu, Wang, Ji, JIANG, Wang, Cui, Wan, Guo and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jian Xu, Department of Orthopedics, Sports Medicine and Arthroscopy. Affiliated Fuyang People's Hospital of Anhui Medical University, No. 501, Sanqing Road, Yingzhou District, Fuyang City,Anhui Province, China
Jinbo Wang, Shanghai Jiao Tong University School of Medicine, No. 937 Zhongshan South 1st Road, Huangpu District, Shanghai, China
Yuncong Ji, Department of Orthopedics, Sports Medicine and Arthroscopy. Affiliated Fuyang People's Hospital of Anhui Medical University, No. 501, Sanqing Road, Yingzhou District, Fuyang City,Anhui Province, China
Yanbo Wang, Department of Orthopedics, Sports Medicine and Arthroscopy. Affiliated Fuyang People's Hospital of Anhui Medical University, No. 501, Sanqing Road, Yingzhou District, Fuyang City,Anhui Province, China
Yunpeng Wan, Department of Orthopedics, Sports Medicine and Arthroscopy. Affiliated Fuyang People's Hospital of Anhui Medical University, No. 501, Sanqing Road, Yingzhou District, Fuyang City,Anhui Province, China
Biao Guo, Department of Orthopedics, Sports Medicine and Arthroscopy. Affiliated Fuyang People's Hospital of Anhui Medical University, No. 501, Sanqing Road, Yingzhou District, Fuyang City,Anhui Province, China
Haiyang Yu, Department of Orthopedics, Sports Medicine and Arthroscopy. Affiliated Fuyang People's Hospital of Anhui Medical University, No. 501, Sanqing Road, Yingzhou District, Fuyang City,Anhui Province, China
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