Skip to main content

REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1483785

Scutellaria baicalensis and its flavonoids in the treatment of digestive system tumors

Provisionally accepted
Kangning Zhao Kangning Zhao 1Jinlong Zhang Jinlong Zhang 1Zhou Lin Zhou Lin 1Zhen Sun Zhen Sun 2*
  • 1 The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China
  • 2 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    Scutellaria baicalensis has been used for the treatment of digestive system disorders for thousands of years in China and other regions. Modern research have revealed its therapeutic efforts in digestive system tumors. Thus, to review the updated progress of Scutellaria baicalensis and its main flavonoids in the treatment of digestive system tumors in the past 10 years, this article summarized the therapeutic effect and molecular mechanisms of Scutellaria baicalensis and its 5 flavonoids on tumors in oral cavity, esophagus, stomach, colon, liver, pancreas by inhibiting tumor cell proliferation, inducing autophagy, stimulating immune response, and increasing drug sensitivity. In conclusion, Scutellaria baicalensis and its flavonoids could be applied to treat digestive system tumors with different type of methods.

    Keywords: Scutellaria baicalensis, Baicalein, Baicalin, tumor, TCM, nature products

    Received: 20 Aug 2024; Accepted: 12 Nov 2024.

    Copyright: © 2024 Zhao, Zhang, Lin and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhen Sun, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, Shandong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.