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MINI REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1477878
This article is part of the Research Topic Preparation, Bioactivity Evaluation, and Quality Control of Natural Products and Their Derivatives View all 16 articles

The isolation, bioactivity, and synthesis of natural products from Litsea verticillate with anti-HIV activities

Provisionally accepted
Junyang Liu Junyang Liu *Jia-Lei Yan Jia-Lei Yan Huiru Nan Huiru Nan Xiaoyu Fang Xiaoyu Fang Xiongen Long Xiongen Long Yu Jiang Yu Jiang
  • School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, China

The final, formatted version of the article will be published soon.

    Natural products isolated from Litsea verticillata have attracted considerable attention from the chemical community due to their unique structures and promising anti-HIV activities. Recent progresses in the isolation and bioactivity studies for these natural molecules were summarized comprehensively. From the 23 previously uncharacterized compounds isolated from the plant Litsea verticillata, litseaverticillol B demonstrated the most potent anti-HIV activity in vitro, with IC50 ranging from 2-3 mg/mL. Meanwhile, litseaverticillol E displayed the highest selectivity index (SI = 3.1), indicating a favorable balance between antiviral potency and cellular toxicity. The plausible biosynthetic pathways and the total synthetic approaches for the representative members (litseaverticillols) were introduced in detail.

    Keywords: litsea verticillate, natural product, Anti-HIV, Total synthesis, bioactive

    Received: 08 Aug 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Liu, Yan, Nan, Fang, Long and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Junyang Liu, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.