AUTHOR=Yan Jia-Lei , Nan Huiru , Fang Xiaoyu , Long Xiong-En , Jiang Yu , Liu Junyang 

TITLE=The isolation, bioactivity, and synthesis of natural products from Litsea verticillate with anti-HIV activities

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1477878

DOI=10.3389/fphar.2024.1477878

ISSN=1663-9812

ABSTRACT=<p>Natural products isolated from <italic>Litsea verticillata</italic> have attracted considerable attention from the chemical community due to their unique structures and promising anti-HIV activities. Recent progresses in the isolation and bioactivity studies for these natural molecules were summarized comprehensively. From the 23 previously uncharacterized compounds isolated from the plant <italic>Litsea verticillata</italic>, litseaverticillol B demonstrated the most potent anti-HIV activity <italic>in vitro</italic>, with IC<sub>50</sub> ranging from 2 to 3 μg/mL. Meanwhile, litseaverticillol E displayed the highest selectivity index (SI = 3.1), indicating a favorable balance between antiviral potency and cellular toxicity. The plausible biosynthetic pathways and the total synthetic approaches for the representative members (litseaverticillols) were introduced in detail.</p>