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REVIEW article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1472670
This article is part of the Research Topic Cellular and Molecular Mechanisms in Metabolic Disorders: Role of Inflammation and Oxidative Stress View all 8 articles

Challenging directions in pediatric diabetes -the place of oxidative stress and antioxidants in systemic decline

Provisionally accepted

The final, formatted version of the article will be published soon.

    Diabetes is a complex condition with a rising global incidence, and its impact is equally evident in pediatric practice. Regardless of whether we are dealing with type 1 or type 2 diabetes, the development of complications following the onset of the disease is inevitable. Consequently, contemporary medicine must concentrate on understanding the pathophysiological mechanisms driving systemic decline and on finding ways to address them. We are particularly interested in the effects of oxidative stress on target cells and organs, such as pancreatic islets, the retina, kidneys, and the neurological or cardiovascular systems. Our goal is to explore, using the latest data from international scientific databases, the relationship between oxidative stress and the development or persistence of systemic damage associated with diabetes in children. Additionally, we highlight the beneficial roles of antioxidants such as vitamins, minerals, polyphenols, and other bioactive molecules; in mitigating the pathogenic cascade, detailing how they intervene and their bioactive properties. As a result, our study provides a comprehensive exploration of the key aspects of the oxidative stress-antioxidants-pediatric diabetes triad, expanding understanding of their significance in various systemic diseases.

    Keywords: diabetes, Children, pro-oxidative status, Antioxidants, nutrition

    Received: 29 Jul 2024; Accepted: 04 Dec 2024.

    Copyright: © 2024 Lupu, Miron, Trandafir, Jechel, STARCEA, Ioniuc, OTILIA, Mocanu, PETRARIU, Danielescu, Nedelcu, Salaru and Lupu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ancuta Lupu, Grigore T. Popa University of Medicine and Pharmacy, Iași, Romania
    Elena Jechel, Grigore T. Popa University of Medicine and Pharmacy, Iași, Romania
    IULIANA MAGDALENA STARCEA, Grigore T. Popa University of Medicine and Pharmacy, Iași, Romania

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.