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REVIEW article

Front. Pharmacol.
Sec. Translational Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1436597
This article is part of the Research Topic Commercialization and Industrialization in Experimental Pharmacology and Drug Discovery: 2023 View all 6 articles

The Versatile Multi-functional Substance NMN: Its Unique Characteristics, Metabolic Properties, Pharmacodynamic Effects, Clinical Trails, and Diverse Applications

Provisionally accepted
Bin Yu Bin Yu 1*Xiaotong Jing Xiaotong Jing 2Lina Jia Lina Jia 1Maoru Wang Maoru Wang 3Liying Liu Liying Liu 4Songyuge Ping Songyuge Ping 4Yu Wang Yu Wang 1Min Yang Min Yang 1
  • 1 Mianyang Central Hospital, Mianyang, China
  • 2 Wuhan University, Wuhan, Hubei Province, China
  • 3 Mianyang Third People's Hospital, Mianyang, China
  • 4 Yantai University, Yantai, Shandong Province, China

The final, formatted version of the article will be published soon.

    β-nicotinamide mononucleotide (NMN) is a naturally occurring biologically active nucleotide widely present in organisms and an inherent substance in the human body. As a critical intermediate in synthesizing coenzyme I (NAD+), it widely participates in multiple biochemical reactions in the human body and is closely related to immunity, metabolism, and other factors. In recent years, NMN has rapidly developed and made significant progress in medicine, food, and healthcare. However, there is currently a lack of comprehensive reports on the research progress of NMN, as well as exploration and analysis of the current research achievements and progress of NMN. Therefore, this review is based on retrieving relevant research on NMN from multiple databases at home and abroad, with the retrieval time from database establishment to May 20, 2024. Subsequently, literature search, reading, key information extraction, organization, and summarization were conducted with the aim of providing a comprehensive and in-depth analysis of the characteristics, metabolic pathways, pharmacological effects, progress in human clinical trials, and wide applications of NMN in drug development and food applications. Furthermore, it offers personal insights into NMN's potential future developments and advancements to present the current development state and existing challenges comprehensively. Ultimately, this review aims to provide guidance and serve as a reference for the future application, innovation, and progression of NMN research.

    Keywords: Chinese medicine, Food, Human clinical trial, Medicine, NMN, Pharmacologic action

    Received: 22 May 2024; Accepted: 17 Sep 2024.

    Copyright: © 2024 Yu, Jing, Jia, Wang, Liu, Ping, Wang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bin Yu, Mianyang Central Hospital, Mianyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.