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REVIEW article
Front. Pharmacol.
Sec. Respiratory Pharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1417834
The critical roles of caveolin-1 in lung diseases
Provisionally accepted- First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
Caveolin-1 (Cav-1), a structural and functional component in the caveolae, plays a critical role in transcytosis, endocytosis, and signal transduction. Cav-1 has been implicated in the mediation of cellular processes by interacting with a variety of signaling molecules. Cav-1 is widely expressed in the endothelial cells, smooth muscle cells, and fibroblasts in the various organs, including the lungs. The Cav-1-mediated internalization and regulation of signaling molecules participate in the physiological and pathological processes. Particularly, the MAPK, NF-B, TGF /Smad, and eNOS/NO signaling pathways have been involved in the regulatory effects of Cav-1 in lung diseases. The important effects of Cav-1 on the lungs indicate that Cav-1 can be a potential target for the treatment of lung diseases. A Cav-1 scaffolding domain peptide CSP7 targeting Cav-1 has been developed. In this article, we mainly discuss the structure of Cav-1 and its critical roles in lung diseases, such as pneumonia, acute lung injury (ALI), asthma, chronic obstructive pulmonary disease (COPD), pulmonary hypertension, pulmonary fibrosis, and lung cancer.
Keywords: caveolin-1, Pneumonia, Asthma, COPD, Ali, pulmonary hypertension, Pulmonary Fibrosis
Received: 17 Apr 2024; Accepted: 09 Sep 2024.
Copyright: © 2024 Fan, Zheng, Wang and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoliang Yuan, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
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