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CORRECTION article

Front. Pharmacol., 08 July 2022
Sec. Pharmacology of Anti-Cancer Drugs

Corrigendum: Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress

  • 1Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Lishui Central Hospital, Lishui, China
  • 2Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

A Corrigendum on
Piperlongumine, aN ovel TrxR1 Inhibitor,Induces Apoptosis in Hepatocellular Carcinoma Cells

by ROS-Mediated ER Stress by Zhang, Q., Chen, W., Lv, X., Weng, Q., Chen, M., Cui, R., Liang, G., and Ji, J. (2019). Front. Pharmacol. 10:1180. doi: 10.3389/fphar.2019.01180

In the original article, there was a mistake in “ Figure 3D” as published. “we unintentionally used the same GAPDH images in the two figures (the GAPDH band below Bcl-2 in Figure 2D is the same one as in the Figure 3D which is below the CyclinB1 in both cells)”. The corrected “Figure 3” appears below.

FIGURE 3
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FIGURE 3. PL induces -induced cell cycle arrest is dependent on intracellular ROS generation in HCC cells. (A) HUH-7 and HepG2 cells were preincubated with or without 5 mM NAC for 2 h before exposure to PL at the indicated concentrations for 16 h. The cell cycle distribution was analyzed by flow cytometry. (B and C) Representative histogram from the cell cycle analysis shown in panel (A). (D) Expression of G2/M phase-related proteins CyclinB1 and CDC2 in HCC cells exposed to the indicated concentration of PL with or without NAC (5 mM) for 20 h. GAPDH was used as an internal control. Data represent similar results from three independent experiments. Error bars represent the S.E.M. of triplicate experiments (*p < 0.05, **p < 0.01).

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher’s Note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: thioredoxin reductase 1, reactive oxygen species, hepatocellular carcinoma, endoplasmic reticular stress, piperlongumine

Citation: Zhang Q, Chen W, Lv X, Weng Q, Chen M, Cui R, Liang G and Ji J (2022) Corrigendum: Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress. Front. Pharmacol. 13:806724. doi: 10.3389/fphar.2022.806724

Received: 20 December 2021; Accepted: 01 June 2022;
Published: 08 July 2022.

Edited and reviewed by:

Olivier Feron, Université Catholique de Louvain, Belgium

Copyright © 2022 Zhang, Chen, Lv, Weng, Chen, Cui, Liang and Ji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Guang Liang, d3ptY2xpYW5nZ3VhbmdAMTYzLmNvbQ==; Jiansong Ji, bHNjaHJqanNAMTYzLmNvbQ==

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.